Optimization of Graphene based biosensor designed with metal oxides and easy electrochemical test with various biomolecules

Optimization of Graphene based biosensor designed with metal oxides and easy electrochemical test with various biomolecules | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Optimization of Graphene based biosensor designed with metal oxides and easy electrochemical test with various biomolecules Latiful Kabir, Young Jun Joo, Kwang Youn Cho, Won-Chun Oh This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6235593/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The purpose of this research is to develop a graphene-based self-assembly method for the easy electrochemical detection of albumin, urea, and ascorbic acid in a nanocomposite (ZnO-G-SnO2). Excessive ingestion of these biomolecules negatively impacts the kidney, liver, and digestive tract. However, the current detection methods for these biomolecules are expensive, time-consuming, and require highly skilled operators. Therefore, we aim to develop an easily detectable method for these biomolecules with good sensitivity. The ZnO-G-SnO2 nanocomposite has unique properties such as high sensitivity, excellent electron mobility, selectivity, low cost, and improved surface attributes, which make it a promising material for sensitive and reliable biosensors. We evaluated the synthesized materials using electrochemical performance instruments, electron attitude regulating spectroscopy, and surface morphology approaches. Under ideal conditions, the sensor is able to detect biomolecules in electrical tests ranging from 0.05 mL to 0.25 mL, demonstrating excellent sensitivity. This analysis confirms the accurate detection of these biomolecules. Graphene based biosensor Electrochemical detection Biomolecules Metal oxide Full Text Supplementary Files supplementarydata250316.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6235593","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":435161906,"identity":"d1efc92e-81c9-46d7-937b-89d2df1d7487","order_by":0,"name":"Latiful Kabir","email":"","orcid":"","institution":"Hanseo University","correspondingAuthor":false,"prefix":"","firstName":"Latiful","middleName":"","lastName":"Kabir","suffix":""},{"id":435161907,"identity":"11457364-fc58-4a82-9d1e-303d0610c81b","order_by":1,"name":"Young Jun Joo","email":"","orcid":"","institution":"KICET: Korea Institute of Ceramic Engineering and Technology","correspondingAuthor":false,"prefix":"","firstName":"Young","middleName":"Jun","lastName":"Joo","suffix":""},{"id":435161908,"identity":"2d9b278f-628f-4e14-b61b-289fdbf737d0","order_by":2,"name":"Kwang Youn Cho","email":"","orcid":"","institution":"KICET: Korea Institute of Ceramic Engineering and Technology","correspondingAuthor":false,"prefix":"","firstName":"Kwang","middleName":"Youn","lastName":"Cho","suffix":""},{"id":435161909,"identity":"4354f4f4-0cf6-4c60-b1a5-9d8f7f99b287","order_by":3,"name":"Won-Chun Oh","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAqElEQVRIiWNgGAWjYDACCRBRYEOyFoM00rUcJkEH/+zmo5t5DM7n8c9IPvaBocYmmrAld46l3eYxuF0scSMteQbDsbTcBkJaDCRyzEBaEhvOnDFmYGw4TIyW/G9ALecS5585/5lYLTlsQC0HEjcc72EmTgvQC2Y35xgkJ2483mbMkECMX4AB9ezGmwq7xHmHmR8zfKixIawFFSSQpnwUjIJRMApGAS4AAP/qPjd8zQuPAAAAAElFTkSuQmCC","orcid":"","institution":"Hanseo University","correspondingAuthor":true,"prefix":"","firstName":"Won-Chun","middleName":"","lastName":"Oh","suffix":""}],"badges":[],"createdAt":"2025-03-16 04:13:01","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6235593/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6235593/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":79846055,"identity":"6be51acf-6331-4a67-b07c-e168150e6827","added_by":"auto","created_at":"2025-04-03 13:44:22","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":3705686,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript250316.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6235593/v1_covered_35ed5606-cd90-4513-bb69-212a73372aed.pdf"},{"id":79788728,"identity":"396086f0-b884-48f5-81ea-37b32b641498","added_by":"auto","created_at":"2025-04-02 17:43:36","extension":"docx","order_by":4,"title":"","display":"","copyAsset":false,"role":"supplement","size":3821508,"visible":true,"origin":"","legend":"","description":"","filename":"supplementarydata250316.docx","url":"https://assets-eu.researchsquare.com/files/rs-6235593/v1/eca534bbd7bb232a480b175c.docx"}],"financialInterests":"","formattedTitle":"Optimization of Graphene based biosensor designed with metal oxides and easy electrochemical test with various biomolecules","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Graphene based biosensor, Electrochemical detection, Biomolecules, Metal oxide","lastPublishedDoi":"10.21203/rs.3.rs-6235593/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6235593/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"The purpose of this research is to develop a graphene-based self-assembly method for the easy electrochemical detection of albumin, urea, and ascorbic acid in a nanocomposite (ZnO-G-SnO2). 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