Development of a novel ultrasound Vacuum -assisted headspace solid phase microextraction approach for determination of solvent residual's in pharmaceuticals and comparison with traditional headspace solid phase microextraction method

Development of a novel ultrasound Vacuum -assisted headspace solid phase microextraction approach for determination of solvent residual's in pharmaceuticals and comparison with traditional headspace solid phase microextraction method | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Development of a novel ultrasound Vacuum -assisted headspace solid phase microextraction approach for determination of solvent residual's in pharmaceuticals and comparison with traditional headspace solid phase microextraction method Somayeh Hajipour, Alireza Ghiasvand This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3823308/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract In this report, an ultrasonication and vacuum assisted headspace solid-phase microextraction procedure followed by gas chromatography-flame ionization detection (UVA-HS-SPME-GC-FID) was proposed for direct extraction of solvent residuals, including benzene, toluene, ethyl benzene, m,p-xylene and o-xylene, in pharmaceutical matrices. A novel robust, reliable and durable nanocomposite solid-phase microextraction (SPME) fiber was prepared by layer-by-layer coating of 3-aminopropyltriethoxysilane-functionalized graphene (APTES) on a stainless-steel wire. Then, the proposed fiber was used for headspace SPME (HS-SPME) and trapping of toluene as a residual solvent in solid penicillin, Ampicillin, and Cefazolin vials followed by gas chromatography-flame ionization detection (GC-FID). UVA-HS-SPME-GC-FID achieves better validation parameters, including limit of detection, limit of quantification, linearity, recovery and repeatability, in comparison with conventional HS-SPME-GC-FID. The UVA-HS-SPME-GC-FID strategy is very effective for quantitative tracing of volatile and semivolatile solvent residuals in various pharmaceutical drugs. ultrasonication and vacuum assisted headspace solid-phase microextraction APTES BTEX solvent residual drug GC–FID Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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