Tertiary Center Experiences in the Follow-Up and Treatment of Endometriosis

In: Southern Clinics of Istanbul Eurasia · 2021 · doi:10.14744/scie.2021.83435 · W3138414664
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This study investigated the demographic characteristics, symptoms, medication use, analgesic needs, and treatment methods of endometriosis patients at a tertiary gynecological clinic to evaluate long-term clinical strategies.

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This retrospective descriptive study examined demographic characteristics, symptoms, medication use (including analgesic needs), diagnostic methods, and medical versus surgical treatment strategies among 1098 endometriosis patients managed at a tertiary gynecology clinic from November 2012 to July 2020. Among findings, most patients had stage 3 disease (873/1098), diagnoses were split between ultrasound (47%) and surgical diagnosis (53%), and hospitalization after laparoscopy was shorter than after laparotomy (2.68±1.02 vs 3.45±1.69 days). For medical therapy, dienogest was most commonly used (525 patients), followed by combined oral contraceptives (110) and progesterone (36). As a case-series chart review, it provides descriptive “tertiary center experience” without explicit comparison of outcomes or a limitation statement beyond its retrospective design. This paper is centrally about endometriosis — it describes tertiary-center demographics, diagnosis, treatment patterns, and follow-up experience.

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Abstract

Objective: Endometriosis is a chronic disease that affects 10% of women of reproductive age. No curative treatment is currently available due to the as yet unclear pathophysiology. Therefore, clinical experience and additional knowledge of the disease has great value. This study was an investigation of the demographic characteristics, symptoms, medication use, analgesic need, and treatment methods of endometriosis patients at a tertiary gynecological clinic in order to evaluate long-term clinical strategies.
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Introduction

Endometriosis is a chronic disease that affects 10% of women of reproductive age. No curative treatment is currently available due to the as yet unclear pathophysiology. Therefore, clinical experience and additional knowledge of the disease has great value. This study was an investigation of the demographic characteristics, symptoms, medication use, analgesic need, and treatment methods of endometriosis patients at a tertiary gynecological clinic in order to evaluate long-term clinical strategies.

Methods

This retrospective, descriptive case study was conducted at a tertiary gynecological clinic. A database search of records from November 2012 to July 2020 yielded a total of 1098 patients for initial inclusion in the study. Age, gravidity, parity, surgical history, and demographic characteristics were recorded, as well as the diagnostic methods, medical and surgical treatment strategies, hospitalization duration, and need for analgesic medication.

Results

In all, 873 patients had stage 3 disease and 6 patients were diagnosed with stage 4 disease. Of the study group, 47% of the patients were diagnosed using ultrasound and 53% were diagnosed surgically. An assessment of the surgical techniques used revealed that 144 patients underwent laparoscopic surgery while 235 underwent a laparotomy. The mean duration of hospitalization following a laparoscopy was 2.68±1.02 days, whereas the mean length of stay following a laparotomy was 3.45±1.69 days. Analysis of the medical treatment strategies applied indicated that 110 patients were given a combined oral contraceptive (COC), 36 received progesterone, and 525 were treated with dienogest.

Discussion

AND CONCLUSION: Although there has been an ongoing search for a curative treatment for endometriosis for some time, the treatment options have not changed dramatically over the years. Laparoscopic surgery has largely taken the place of a laparotomy as surgeons became more experienced and progestins have gained more importance as a medical treatment option. However, at present, regardless of treatment strategy, endometriosis still requires a long period of treatment and follow-up.

Keywords

Combined oral contraceptive, endometriosis; endometriosis surgery; hormonal therapy; progestin. 2Sağlık Bilimleri Üniversitesi, İstanbul Şişli Hamidiye Etfal Eğitim Ve Araştırma Hastanesi, Kadın Hastalıkları Ve Doğum Kliniği İstanbul GİRİŞ ve AMAÇ: Endometriyozis, üreme çağındaki kadınların %10’unu etkileyen kronik bir hastalıktır. Belirsiz patofizyoloji nedeniyle, küratif bir tedavi seçeneği mevcut değildir. Bu nedenle hastalıkla ilgili klinik deneyim ve artan bilgi birikimi büyük önem taşımaktadır. Bu çalışmanın amacı, uzun dönem klinik stratejileri değerlendirmek için üçüncü basamak bir jinekoloji kliniğinde endometriyozis hastalarının demografik özelliklerini, semptomlarını, tıbbi alımını, analjezik ihtiyacını ve tedavi yöntemlerini araştırmaktır. YÖNTEM ve GEREÇLER: Bu geriye dönük tanımlayıcı olgu çalışması, üçüncü basamak bir jinekoloji kliniğinde gerçekleştirildi. Kasım 2012 ile Temmuz 2020 arasında bir veri tabanı araştırması yapıldı ve toplam 1098 hasta çalışmaya dahil edildi. Hastaların yaş, gravite, parite, ameliyat öyküsü ve demografik özellikleri kaydedildi. Tanı yöntemleri, tıbbi ve cerrahi tedavi stratejileri, hastanede kalış süresi ve analjezik ilaç ihtiyacı için medikal dosyalar tarandı. BULGULAR: Sekiz yüz yetmiş üç hasta evre 3 hastalığa sahipken, sadece altı hastaya evre 4 hastalık teşhisi konmuştur. Hastaların %47’si ultrason ile, %53’ü cerrahi olarak teşhis edildi. Hastalar cerrahi tekniklere göre değerlendirildiğinde 144 hastaya laparoskopik, 235 hastaya laparotomi yapıldı. Laparoskopi sonrası ortalama hastanede kalış süresi 2.68±1.02, laparotomi sonrası ortalama süre 3.45±1.69 olarak hesaplandı. Tıbbi tedavi stratejileri açısından kayıtların incelenmesi, 110 hastanın kombine oral kontraseptif (KOK), 36’sının progesteron ve 525’inin dienogest aldığını ortaya koydu. TARTIŞMA ve SONUÇ: Endometriyozisin iyileştirici tedavisi için büyük bir arayış bir süredir devam etse de, tedavi seçenekleri yıllar içinde büyük ölçüde değişmedi. Cerrahların tecrübesi arttıkça, endometriyozis cerrahisinde laparotominin yerini laparoskopik cerrahi almıştır. Ayrıca tıbbi tedavi seçenekleri olarak progestinler daha fazla önem kazanmıştır. Bununla birlikte, tedavi stratejilerine bakılmaksızın, endometriyozis hastalarının hala uzun süreli tedavilere ve takiplere ihtiyacı vardır. Anahtar Kelimeler: Endometriozis, endometriozis cerrahisi; hormon tedavisi; kombine oral kontraseptif; progestin. Corresponding Author: Pınar Yalçn Bahat, Türkiye Manuscript Language: English Manuscript Language: English

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