PATHOGENETIC SUBSTANTIATION OF OPTIMISATION OF DIAGNOSIS AND TREATMENT OF ADENOMYOSIS

The urgency of studying the problem lies in the fact that the question of the pathogenetic factors of adenomyosis remain unresolved, which makes it difficult to choose an adequate treatment strategy for the management of patients. The purpose of the work: improving the quality of diagnosis and the effectiveness of treatment of patients with adenomyosis through the pathogenetic justification of the optimization of patient management tactics. Material and methods: 115 female patients of reproductive age were examined. The I clinical group (control) consisted of 30 healthy fertile women. The II clinical group included 85 patients with adenomyosis. Among the patients with adenomyosis, two subgroups were selected. In the comparison subgroup, there are 40 patients who received traditional treatment in accordance with the order of the Ministry of Health of Ukraine No. 319 dated 04/06/2016. In the main subgroup - 45 patients received complex treatment (hormonal and immunocorrective). In order to correct disorders in the body's immunoreactivity, in addition to the basic hormonal therapy, an immunostimulating drug and an inducer of the synthesis of endogenous interferons were used. Clinical-laboratory, instrumental, clinicalgenealogical, immunological, biochemical, microbiological, pathomorphological, statistical methods were performed on all patients. Results. The conducted study showed that complex therapy has an earlier and stable clinical effect, compared to traditional treatment, there is a faster and significant reduction of pain syndrome, improvement of immunological status, normalization of indicators of phagocytic and oxygen activity of neutrophils and monocytes in peripheral blood was found. Conclusions. Based on the results of the work, the approaches to the treatment of adenomyosis patients were optimized, the feasibility of using immunocorrective drugs for the treatment of the disease was substantiated.