Carcinosarcomas (Malignant Mullerian Mixed Tumors) of the Uterus and Ovary: A Genetic Study With Special Reference to Histogenesis

Zhe Jin, Shinya Ogata, Gen Tamura, Yousei Katayama, Masayuki Fukase, Mihoko Yajima, Teiichi Motoyama
In: International Journal of Gynecological Pathology · 2003 · vol. 22(4) , pp. 368–373 · doi:10.1097/01.pgp.0000092134.88121.56 · PMID:14501818 · W2028008318
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This study analyzed X-chromosome inactivation, p53/K-ras mutations, and microsatellites in 15 uterine and ovarian carcinosarcomas, finding most to be monoclonal in origin.

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Abstract

The histogenesis of carcinosarcomas (malignant mullerian mixed tumors) of the female genital tract is still not completely understood. In the present study, several different molecular pathologic techniques were applied to determine the histogenesis of 15 uterine and ovarian carcinosarcomas. The patterns of X-chromosome inactivation and the presence of p53 and K-ras mutations were analyzed in the carcinomatous and sarcomatous components. Microsatellite analysis was also performed. Ten tumors were monoclonal, one was biclonal (collision tumor), and another was probably biclonal; the other three were of indeterminate histogenesis. These data indicate that most uterine and ovarian carcinosarcomas are monoclonal.
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ORIGINAL CONTRIBUTIONS Carcinosarcomas (Malignant Mullerian Mixed Tumors) of the Uterus and Ovary: A Genetic Study With Special Reference to Histogenesis - Zhe Jin - Shinya Ogata - Gen Tamura - Yousei Katayama - Masayuki Fukase - Mihoko Yajima - Teiichi Motoyama International Journal of Gynecological Pathology 22(4):p 368-373, October 2003. | DOI: 10.1097/01.pgp.0000092134.88121.56 Summary: The histogenesis of carcinosarcomas (malignant mullerian mixed tumors) of the female genital tract is still not completely understood. In the present study, several different molecular pathologic techniques were applied to determine the histogenesis of 15 uterine and ovarian carcinosarcomas. The patterns of X-chromosome inactivation and the presence of p53 and K-ras mutations were analyzed in the carcinomatous and sarcomatous components. Microsatellite analysis was also performed. Ten tumors were monoclonal, one was biclonal (collision tumor), and another was probably biclonal; the other three were of indeterminate histogenesis. These data indicate that most uterine and ovarian carcinosarcomas are monoclonal. Copyright ©2003International Society of Gynecological Pathologists

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