Clinicopathological correlation of endometrial, myometrial and ovarian pathologies with secondary changes in leiomyoma

Seema Dayal, Arun Nagrath
In: Journal of Pathology of Nepal · 2016 · vol. 6(11) , pp. 937–941 · doi:10.3126/jpn.v6i11.15677 · W2519614512
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study examined hysterectomy specimens, finding that menorrhagia was the most common symptom of uterine leiomyoma, which frequently coexisted with proliferative phase endometrium, endometrial hyperplasia, and adenomyosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This clinicopathological study analyzed 437 hysterectomy specimens (Jan 2008–Dec 2015) to describe clinical symptoms and to diagnose coexisting endometrial, myometrial, and ovarian pathologies associated with uterine leiomyoma, using gross examination, H&E staining, and pathologist review. The most common symptom was menorrhagia (60.86%), and the most frequent endometrial change was the proliferative phase (48.51%), with endometrial hyperplasia present in 5.03%. Degenerative myometrial-associated changes included a higher occurrence of degenerative changes in the setting of proliferative phase (42.1%), and hyaline degeneration was reported as frequent (15.33%), while adenomyosis was seen in 15.10% and the common ovarian finding was a simple serous cyst (6.40%). The paper’s main limitation is that it relies on correlations within hysterectomy specimens, which constrains inference about causality. Relevance to endometriosis/adenomyosis: adenomyosis is reported as a coexisting pathology (15.10%) among cases with uterine leiomyoma, making this paper directly relevant to adenomyosis.

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Abstract

Background: Leiomyomas are the most common benign uterine neoplasm in women of reproductive age group. Uterine leiomyoma are steroid dependent tumors. Leiomyomas are diagnosed by the clinical examination, ultra sound and histopathological examination of the hysterectomy specimens. The aim of this study was to know the clinical symptoms and to diagnose endometrial, ovarian, and other associated coexisting pathologies with leiomyoma and their correlation with leiomyoma.Materials and Methods: Present study was conducted on hysterectomy specimens between January 2008 to 31 December 2015 in the Pathology Department of Rural Institute of Medical Sciences and Research, Saifai, Uttar Pradesh, India. Specimens were grossly examined, sectioned and hematoxylin and eosin stain was applied. Slides were reviewed by pathologist and diagnosis was made.Results: A total of 437 patients were included. The common age group of patients with leiomyoma was 31-40 (42.10 %). Menorrhagia (60.86 %) was the prime clinical symptom. Among endometrial pathologies and changes, proliferative phase was maximum ( 48.51 %) and endometrial hyperplasia was ( 5.03%) . Proliferative phase was seen more with degenerative changes (42.1%) and hyaline degenerative was frequent (15.33 %). Adenomyosis was also seen (15.10 %). The common pathologies in ovary were simple serous cyst (6.40 %).CONCLUSION – Leiomyoma uteri is a myometrial pathology presenting with clinical symptom of menorrhagia. Proliferative phase, endometrial hyperplasia were common endometrial changes and pathology. Adenomyosis was also common. Chocolate cyst in ovary was also seen which all shows a strong association of hyperestrogenic state being responsible for leiomyoma and all associated pathologies.
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Background

Leiomyomas are the most common benign uterine neoplasm in women of reproductive age group. Uterine leiomyoma are steroid dependent tumors. Leiomyomas are diagnosed by the clinical examination, ultra sound and histopathological examination of the hysterectomy specimens. The aim of this study was to know the clinical symptoms and to diagnose endometrial, ovarian, and other associated coexisting pathologies with leiomyoma and their correlation with leiomyoma.

Materials and methods

Present study was conducted on hysterectomy specimens between January 2008 to 31 December 2015 in the Pathology Department of Rural Institute of Medical Sciences and Research, Saifai, Uttar Pradesh, India. Specimens were grossly examined, sectioned and hematoxylin and eosin stain was applied. Slides were reviewed by pathologist and diagnosis was made.

Results

A total of 437 patients were included. The common age group of patients with leiomyoma was 31-40 (42.10 %). Menorrhagia (60.86 %) was the prime clinical symptom. Among endometrial pathologies and changes, proliferative phase was maximum ( 48.51 %) and endometrial hyperplasia was ( 5.03%) . Proliferative phase was seen more with degenerative changes (42.1%) and hyaline degenerative was frequent (15.33 %). Adenomyosis was also seen (15.10 %). The common pathologies in ovary were simple serous cyst (6.40 %).

Conclusion

– Leiomyoma uteri is a myometrial pathology presenting with clinical symptom of menorrhagia. Proliferative phase, endometrial hyperplasia were common endometrial changes and pathology. Adenomyosis was also common. Chocolate cyst in ovary was also seen which all shows a strong association of hyperestrogenic state being responsible for leiomyoma and all associated pathologies. Downloads Downloads Published How to Cite Issue Section License This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.

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