Unusual specific interaction of RBD with zeolite induces rapid neutralization of SARS-CoV-2

Abstract RBD-ACE2 interaction is critical in mediating SARS-CoV-2 attachment to its host cells. Blocking the attachment by inhibiting RBD-ACE2 binding is an effective way to prevent COVID-19 infection. In this study, we demonstrate that copper-ion exchanged zeolite (Cu-zeolite) binds specifically to RBD of SARS-CoV-2 via an unusual specific copper-content-dependent interaction of Cu-zeolite with RBD. Accordingly, Cu-zeolites prevent the virions from interacting with host cells, contributing to efficient and rapid SARS-CoV-2 neutralization. Therefore, Cu-zeolite has the potential to serve as a feasible and effective preventive measure to reduce exposure to the virus and as a therapeutic agent for post-exposure treatment of COVID-19.