Laparoscopic ovarian drilling-plus: a one-stop management approach for PCO-associated infertility

In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology · 2017 · vol. 6(11) , pp. 4771 · doi:10.18203/2320-1770.ijrcog20174985 · W2766384903
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AI-generated summary by gemini-2.5-flash-lite, 2026-06-13

Laparoscopic ovarian drilling detected and treated concomitant pelvic pathologies in infertile women, particularly those with risk factors, as a valuable one-stop management approach for PCOS-associated infertility.

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This prospective cross-sectional observational study evaluated infertile women planned for diagnostic/operative laparoscopy, comparing clomiphene-resistant PCOS (n=116) with non-PCOS infertile controls (n=116), and further stratifying by risk factors for adhesion formation. Laparoscopy detected pelvic abnormalities in 37.9% of women with PCOS and 74.1% of controls overall, with variation by adhesion risk factors within each group; all detected concomitant pelvic pathologies were treated on a “one-stop” see-and-treat basis. The paper’s key limitation is its cross-sectional design focused on prevalence and intraoperative management without reporting infertility outcomes after the laparoscopic interventions. Relevance to endometriosis: the study does not explicitly discuss endometriosis or adenomyosis, but it is included in the corpus via keyword match related to laparoscopy-associated infertility evaluation, which can overlap with conditions such as endometriosis/adenomyosis in broader pelvic-pain infertility contexts.

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Abstract

Background: The current study aims to estimate additional values of laparoscopic intervention for diagnosis and treatment of concomitant pelvic pathologies among infertile women with clomiphene-resistant polycystic ovarian syndrome (PCOS) subjected to laparoscopic ovarian drilling (LOD) in comparison to non-PCOS infertile women subjected to diagnostic/therapeutic laparoscopy.Methods: A prospective cross sectional observational study was carried out in the Endoscopic unit of a tertiary care university hospital. The study included 232 infertile women planned for laparoscopy were divided into a study group A (116 cases) with clomiphene-resistant PCOS and a control group B (116 cases) without PCOS. Each group was further subdivided into two subgroups according to the presence and absence of risk factors (RF) for adhesion formation. Diagnostic/operative laparoscopy was done. The main study outcome was the prevalence of any pelvic abnormalities seen during laparoscopy.Results: Both groups showed insignificant difference regarding socio-demographic history and basic data. Laparoscopy detected pelvic pathologies in 44 cases (37.9%) and 86 cases (74.1%) in both groups respectively. In group A, we diagnosed pelvic pathologies in 29 (32.6%) and 15 (55.6%) cases with and without RF respectively while in group B they were diagnosed in 76 (84.4%) and 10 (38.5%) cases with and without RF respectively. If compared to women with unexplained infertility, PCO patients without risk factors have an insignificant but higher prevalence of pelvic abnormalities. All concomitant pelvic pathologies in both groups were treated on a one-stop (see and treat) basis.Conclusions: Detection and proper management of associated pelvic pathologies at laparoscopy is a valuable additional advantage of LOD particularly in women with positive risk factors. LOD plus see and treat associated pathologies is a time saving and prompt management approach for women with PCO–associated infertility.
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Background

The current study aims to estimate additional values of laparoscopic intervention for diagnosis and treatment of concomitant pelvic pathologies among infertile women with clomiphene-resistant polycystic ovarian syndrome (PCOS) subjected to laparoscopic ovarian drilling (LOD) in comparison to non-PCOS infertile women subjected to diagnostic/therapeutic laparoscopy.

Methods

A prospective cross sectional observational study was carried out in the Endoscopic unit of a tertiary care university hospital. The study included 232 infertile women planned for laparoscopy were divided into a study group A (116 cases) with clomiphene-resistant PCOS and a control group B (116 cases) without PCOS. Each group was further subdivided into two subgroups according to the presence and absence of risk factors (RF) for adhesion formation. Diagnostic/operative laparoscopy was done. The main study outcome was the prevalence of any pelvic abnormalities seen during laparoscopy.

Results

Both groups showed insignificant difference regarding socio-demographic history and basic data. Laparoscopy detected pelvic pathologies in 44 cases (37.9%) and 86 cases (74.1%) in both groups respectively. In group A, we diagnosed pelvic pathologies in 29 (32.6%) and 15 (55.6%) cases with and without RF respectively while in group B they were diagnosed in 76 (84.4%) and 10 (38.5%) cases with and without RF respectively. If compared to women with unexplained infertility, PCO patients without risk factors have an insignificant but higher prevalence of pelvic abnormalities. All concomitant pelvic pathologies in both groups were treated on a one-stop (see and treat) basis.

Conclusions

Detection and proper management of associated pelvic pathologies at laparoscopy is a valuable additional advantage of LOD particularly in women with positive risk factors. LOD plus see and treat associated pathologies is a time saving and prompt management approach for women with PCO–associated infertility. Metrics

References

Ehrman DA. Polycystic ovary syndrome. New Eng J Med. 2005;352:1223-36. Thomas S, Sudharshini S. Polycystic ovarian syndrome: Treatment options for infertility. Curr Med Issues. 2016;14(4):87-93. Diamanti-Kandarakis E, Kouli CR, Bergiele AT, Filandra FA, Tsianateli TC, Spina GG, et al. A survey of the polycystic ovary syndrome in the Greek island of Lesbos: Hormonal and metabolic profile. J Clin Endocrinol Metab. 1999;84:4006-11. Darwish AM, Metwally AB, Shaaban MM, Mohamed S. Monopolar versus bipolar laparoscopic ovarian drilling in clomiphene-resistant polycystic ovaries (PCO): a preliminary study. Gynecol Surg. 2016;13(3):179-85. Amin AF, Abd El Aal DE, Darwish AM, Meki AM. Evaluation of the impact of laparoscopic ovarian drilling on Doppler indices of ovarian stromal blood flow, serum vascular endothelial growth factor, and insulin-like growth factor-1 in women with polycystic ovary syndrome. Fertil Steril. 2003;79(4):938-4. Practice Committee of the American Society for Reproductive Medicine. Diagnostic evaluation of the infertile female: a committee opinion. Fertil Steril. 2015 Jun;103(6):e44-50. Al-Hussaini TK, Zakhera MS, Abdel-Aleem M, Abbas AM. Premature ovarian failure/dysfunction following surgical treatment of polycystic ovarian syndrome: A case series. Middle East Fertil Soc. 2017;22(3):233-5. Salem MN, Ahmed SR, Abbas AM, Salem AN, Sabala AM. Short term effects of laparoscopic ovarian drilling in clomiphene citrate resistant patients with polycystic ovary syndrome. Middle East Fertil Soc. 2017 [Article in press]. Kristin JH, Ricardo FS, David AF, Paul BM, Lee Higdon H, Creighton EL et al. Coexistence of polycystic ovary syndrome and endometriosis in women with infertility. J Endometr Pelvic Pain Disord. 2014;6(2):79-83. Abu Hashim H, Al-Inany H, De Vos M, Tournaye H. Three decades after Gjönnaess's laparoscopic ovarian drilling for treatment of PCOS; what do we know? An evidence-based approach. Arch Gynecol Obstet. 2013;288(2):409-22. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19-25. Lebbi E, Ben Tamemi R, Fadhlaoui A, Fekri A. Ovarian drilling in PCOS: is it really useful? Frontiers in Surgery. 2015;2:30. Saha L, Kaur S, Saha PK. N-acetyl cysteine in clomiphene citrate resistant polycystic ovary syndrome: A review of reported outcomes. J Pharmacol Pharmacother. 2013;4(3):187-91. Brinsden PR, Wada I, Tan SL, Balen A, Jacobs HS. Diagnosis, prevention and management of ovarian hyperstimulation syndrome. Br J Obstet Gynecol. 1995;102:767-72. Sallam NH, Abdel-Bak M, Sallam NH. Does ovulation induction increase the risk of gynecological cancer? Facts Views Vis Obgyn. 2013;5(4):265-73. Darwish AM. Endoscopic Explanation of unexplained infertility in contemporary gynecologic practice. Edited by Atef Darwish. In Tech Pub Feb 2015, Chapter 1. Poujade O, Gervaise A, Faivre E, Deffieux X, Fernandez H. Surgical management of infertility due to polycystic ovarian syndrome after failure of medical management. Eur J Obstet Gynecol Reprod Biol. 2011;158(2):242-7. Mitra S, Nayak PK, Agrawal S. Laparoscopic ovarian drilling: An alternative but not the ultimate in the management of polycystic ovary syndrome. J Nat Sci Biol Med. 2015;6(1):40-8. Pasquali R, Casimirri F. The impact of obesity on hyperandrogenism and polycystic ovary syndrome in premenopausal women. Clin Endocrinol. 1993;39:1-16. Darwish AM, Mohamed EE. One-stop infertility evaluation unit. In Testes ovaries- Similarities and discrepancies. Edited by Darwish AM, Intch Pub Co, 2017;chapter 3. Siam S, Soliman BS. Combined laparoscopy and hysteroscopy for the detection of female genital system anomalies results of 3,811 infertile women. J Reprod Med. 2013;59(11-12): 542-6. Tsuji I, Ami K, Miyazaki A, Hujinami N, Hoshiai H. Benefit of diagnostic laparoscopy for patients with unexplained infertility and normal hysterosalpingography findings. Tohoku J Exp Med. 2009;219(1):39-42.

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