Interventional fallopian tube recanalization combined with ozone injection in treating chronic obstructive salpingitis: an experimental study in rabbits

Objective To assess the therapeutic value of interventional fallopian tube recanalization(FTR) combined with ozone injection in treating chronic obstructive salpingitis in experimental rabbits in order to provide references for clinical application.Methods The animal model of chronic obstructive salpingitis was established through interventional uterotubal catheterization in New Zealand white rabbits.A total of 40 rabbit models with salpingitis were randomly and equally divided into four groups: group A(30 μg/ml ozone),group B(40 μg/ml ozone),group C(conventional interventional treatment) and group D(modeling control group).Another ten healthy rabbits were used as a blank control group(group E).After interventional FTR was successfully finished,10 ml of 30 μg/ml ozone and 40 μg/ml ozone was injected through the catheter into each fallopian tube in the rabbits of group A and group B respectively,while anti-inflammatory drug was given to the rabbits in group C,and 10 ml of saline was injected in the rabbits of both group D and group E.Four weeks after the treatment,the experimental rabbits were sacrificed,and the fallopian tubes were collected and sent for macroscopic and microscopic examination.Results The recanalization rate of the fallopian tube in group A,B,C and D was 88.9%,85.0%,88.9% and 81.3%,respectively.The severity of salpingitis observed in group A,B and C was significantly improved when compared to that observed in group D(P 0.05).Statistically significant difference in the therapeutic effect existed between group A and C,as well as between group B and C(P 0.05),although the difference between group A and group B was not statistically significant(P 0.05).Conclusion Additional use of ozone injection with the concentration of 30 μg/ml or 40 μg/ml following interventional fallopian tube recanalization management can surely improve the chronic obstructive salpingitis to a certain degree in experimental rabbits.This technique might be advocated in clinical practice.