What is the evidence for the use of GnRH analogues for more than 6 months in treating endometriosis or uterine fibroids?

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2026 · doi:10.5281/zenodo.21336882 · W7168121589
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Strong evidence supports GnRH analogue use for up to 6 months for endometriosis and uterine fibroids, with longer use necessitating careful management of side effects, especially bone health, through add-back therapies.

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Abstract

Long-term use of GnRH analogues for endometriosis and uterine fibroids is limited, with strong evidence supporting up to 6 months. Longer durations require careful management of side effects, notably bone health, potentially utilizing add-back therapies.
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Published July 13, 2026 | Version v1 Other Open What is the evidence for the use of GnRH analogues for more than 6 months in treating endometriosis or uterine fibroids? Description Long-term use of GnRH analogues for endometriosis and uterine fibroids is limited, with strong evidence supporting up to 6 months. Longer durations require careful management of side effects, notably bone health, potentially utilizing add-back therapies. Files 33de8a9d-1514-4a88-b2f5-3f29a2c79aff.pdf Files (18.5 kB) | Name | Size | Download all | |---|---|---| | md5:1aebb9405bebc71e4baf3f3c0887a5cf | 18.5 kB | Preview Download |

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