Alcohol Use Disorder: A Comprehensive Review of Its Neurobiological Mechanisms, Treatment Strategies, and Societal Impact

Alcohol Use Disorder: A Comprehensive Review of Its Neurobiological Mechanisms, Treatment Strategies, and Societal Impact | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 10 March 2025 V1 Latest version Share on Alcohol Use Disorder: A Comprehensive Review of Its Neurobiological Mechanisms, Treatment Strategies, and Societal Impact Authors : Rutuja Desai , Vijayapandi Pandy , and Ashwin Kuchekar 0000-0003-2630-6713 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174159613.35853188/v1 290 views 213 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Alcohol Use Disorder (AUD) is a chronic, multifaceted condition defined by compulsive alcohol consumption and its detrimental effects on health and society. This article explores the neurobiological mechanisms and behavioural cycles associated with AUD, highlighting the three interconnected stages: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. These stages illustrate the complex interplay between psychological dependence and neurobiological adaptations, contributing to the persistence of the disorder. The global prevalence of AUD is significant, with millions affected, yet a substantial treatment gap exists, driven largely by stigma and lack of access to care. Current treatment modalities, including psychosocial interventions and pharmacological options, are reviewed, revealing the need for enhanced strategies to address AUD effectively. Future directions in AUD management are discussed, emphasizing the promise of personalized medicine and advancements in neurobiological research to tailor treatments to individual needs. Additionally, the article advocates for the integration of digital health technologies and telehealth solutions to improve treatment accessibility and engagement. Community-based strategies play a crucial role in reducing stigma and fostering supportive environments that promote recovery. Ultimately, this review underscores the urgency of a comprehensive, multi-dimensional approach to AUD that combines clinical research, innovative treatment methods, and community involvement to improve outcomes for individuals and reduce the societal burden of alcohol use disorders. Supplementary Material File (aud review_14-02-2025.docx) Download 806.39 KB Information & Authors Information Version history V1 Version 1 10 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords alcohol use disorder dependence neurobiology treatments and dosage forms withdrawal Authors Affiliations Rutuja Desai Dr Vishwanath Karad MIT World Peace University School of Health Sciences & Technology View all articles by this author Vijayapandi Pandy Dr Vishwanath Karad MIT World Peace University School of Health Sciences & Technology View all articles by this author Ashwin Kuchekar 0000-0003-2630-6713 [email protected] Dr Vishwanath Karad MIT World Peace University School of Health Sciences & Technology View all articles by this author Metrics & Citations Metrics Article Usage 290 views 213 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Rutuja Desai, Vijayapandi Pandy, Ashwin Kuchekar. Alcohol Use Disorder: A Comprehensive Review of Its Neurobiological Mechanisms, Treatment Strategies, and Societal Impact. Authorea . 10 March 2025. DOI: https://doi.org/10.22541/au.174159613.35853188/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. 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