Index of Subjects

ABCG2, cancer cell hierarchy and, human HCC, 1750 Abdominal aortic aneurysms, MMPs and cathepsins in collagen degradation, 809 ABPM. see Allergic bronchopulmonary mycosis Acetylcholinesterase receptor, increased in muscle by rapsyn expression, EAMG (rat), 644 Acid sphingomyelinase, deficiency, sperm abnormalities in (knockout mouse), 2077 Acute disseminated encephalomyelitis, MS and, autoimmunity model, commentary, 436 Acute myocardial infarction, C. pneumoniae infection of cardiomyocytes correlated with, 33 Adaptive immunity, GR signaling in T cells affects thymocyte apoptosis and immune responses (rat and mouse), 1041 ADEM. see Acute disseminated encephalomyelitis Adipocytes hypoxic, role in early heterotopic bone formation (NOD-SCID mouse), 620 leptin-dependent TLR expression and responsiveness, preadipocytes and (mouse), 1931 Adrenomedullin, protects from EA via Th1 response and Treg cell induction (mouse), 263 Age/aging caspase-6 activation in MCI and, 1200 ovarian, countered by COX-2 reduction (Wv mouse), 1325 vascular, TNF-α in (rat), 388 Aggrus, promotes pulmonary metastases, mouse, 1337 AhR. see Aryl hydrocarbon receptor AIMP1. see Amino acyl-tRNA synthetase-interacting multifunctional protein 1 Allergic bronchopulmonary mycosis, GM-CSF in C. neoformans infection during (mouse), 1028 Alzheimer's disease caspase-6 activation in aging and MCI, 1200 lactadherin in, 921 lithium reduces tau phosphorylation (transgenic mouse), 1669 treating the lesions, not the disease, commentary, 1457 Amino acyl-tRNA synthetase-interacting multifunctional protein 1, controls ER retention of gp96 (mouse), 2042 Amyloid-β, IFN-γ and TNF-α regulate plaque deposition and β-secretase expression (APP/GRKO mouse), 680 Anaphase-promoting complex MAD2-mediated inhibition of, RB dysregulation causes DMT1 overexpression via, 1585 tumor overexpression of oncogenic regulators and substrates of APC/C, 1793 Aneurysms, abdominal aortic, MMPs and cathepsins in collagen degradation, 809 Angiogenesis accelerated by hyaluronan via stroma cells, Neu-induced mammary tumors (mouse), 1086 alternative vascularization mechanisms, cancer, perspectives, 1 corneal, bFGF-induced, proangiogenic role of ephrin-B1/EphB1 (mouse), 764 VPCs capable of induction of vasculogenesis and, human fetal aorta, 1879 Angiopoietin-1, VEGF and, stimulate migration of human HSCs (rat and human), 1942 Angiotensin-converting enzyme, macrophages enhanced in, melanoma-resistance and (mouse), 2122 Angiotensin receptors, effect of AT1R and AT2R on podocytes, glomerular capillary wall (rat), 1841 Animal models colon cancer, microinjection of human tumor cells induces metastatic sites (nude mouse), 1077 EAE, neuronal CD200 expression and neurodegeneration ( Wld s mouse), 1695 erythrophagocytosis by liver macrophages, steatohepatitis (rabbit), 967 evaluation of therapeutic strategies for cancer, review (mouse), 793 HCV, thymic stromal lymphopoietin in cryoglobulinemia and hepatitis (transgenic mouse), 981 NKT cell response in adoptive transfer model of atherosclerosis (mouse), 1100 Annexin 2 in ERK 1/2 activation in tPA-induced pancreatic cancer cell proliferation, 1573 regulates intestinal epithelial cell spreading and wound closure via Rho, 951 Anti-neutrophil cytoplasmic autoantibodies, alternative complement pathway in ANCA-mediated disease (mouse), 52 Aorta, human fetal, contains VPCs capable of vasculogenesis induction, 1879 Arthritis CRH-R1α in mediating responses, chronically inflamed synovial tissue, 1121 experimental, adrenomedullin protection from, via Th1 response and Treg cell induction (mouse), 263 experimental, effects of prednisolone and calcitonin on bone (rat), 1018 Aryl hydrocarbon receptor, RelB and, in inflammatory responses to cigarette smoke (mouse), 855 Asbestos, peribronchiolar proliferation induced by, inhibited in PKC-δ knockout model (mouse), 140 ASM. see Acid sphingomyelinase Atherosclerosis early, reduced by C1q (LdlR-deficient mosue), 416 mitochondrial thioredoxin expression improves EC function and reduces lesions (mouse), 1108 NKT cell response in adoptive transfer model of (mouse), 1100 Autoantibodies CNS-specific, viral encephalitis pathology with (mouse), 557 to vimentin, accelerate cardiac allograft rejection (mouse), 1415 Autoimmune diseases, ameliorated by DAF (MRL/lpr mouse), 1258 Autoimmunity, models of, MS and ADEM, commentary, 436 Autophagy, regulation by ERK during MPP-induced cell death, 75 Axons, degeneration in EAE and TMEV models of MS (mouse), 214 B cells CCR6 expression and development of ILF (mouse), 1229 role in renal interstitial inflammation, 457 in switch from C protein-induced myocarditis to DCM (rat), 43 Basal cell carcinoma, differential ErbB1 signaling in SCC vs. , skin, 2089 Bcl II gene, Hedgehog promotes survival via, medulloblastomas, 347 Beclin-1, role in autophagy following MPP-induced cell death, 75 β-Cells, carcinogenesis, VEGF-D in lymphangiogenesis and metastasis (Rip1Tag2 mouse), 1348 BL5923, as potential therapy for diabetic nephropathy (db/db mouse), 1267 Bmi-1, essential for tumorigenicity, neuroblastomas (mouse), 1370 Bone early heterotropic formation, hypoxic adipocytes in (NOD-SCID mouse), 620 effects of prednisolone and calcitonin, experimental arthritis (rat), 1018 metastases, Noggin determines osteoblast responses (mouse), 160 resorption, P. gingivalis -caused, promoted by Th1 cell immune responses (mouse), 203 Borrelia turicatae , RF spirchete, IL-10 during infection with (mouse), 251 Brain gestational vitamin B deficiency causes homocysteine-associated apoptosis (rat), 667 IL-1R1 essential for control of cerebral listeriosis (mouse), 990 Breast cancer DMBT1 gene modifies risk of mammary tumor and (mouse and human), 2030 epigenetic reversion of phenotype, 1739 fibroblasts in modulation of tamoxifen sensitivity, 1546 human breast fibroblasts inhibit growth of MCF10AT xenografts (nude mouse), 1064 laminin-511 in metastatic progression (mouse), 2135 progression associated with loss of Fibulin-2 expression, 1535 WAVE3 gene in invasion and metastases (mouse and human), 2112 C-Reactive protein, affinity towards FcγRI, 755 E-Cadherin, claudin-7 regulates invasion of esophageal SCC cells and expression of, 709 Calcitonin, prednisolone and, effects on bone and experimental arthritis (rat), 1018 Calpain, cleavage of α-synuclein, 1725 Cancers alternative vascularization mechanisms, perspectives, 1 murine models in evaluation of therapeutic strategies for, review (mouse), 793 Noggin determines osteoblast responses, bone metastases (mouse), 160 Capillary density, impairment of, but not oxygen delivery, experimental malaria (window chamber model, hamster), 505 Cardiac hypertrophy, aberrant expression of microRNAs (mouse), 1831 Cardiomyocytes C. pneumoniae infection of, correlated with AMI, 33 Smad5 required for cardiac homeostasis (mouse), 1460 Cardiomyopathy, dilated, B cells in switch from C protein-induced myocarditis to (rat), 43 Carotid arteries, protective effect of hydrogen sulfide on neointima-hyperplasia (rat), 1406 Caspase-6, activation in aging and MCI, 1200 Caspase 8, IFN-γ sensitizes Ewing's sarcoma to TRAIL-induced apoptosis via, 1917 Cathepsin G, in inflammation and tissues after I/R injury (mouse), 930 Cathepsins, MMPs and, in collagen degradation, abdominal aortic aneurysms, 809 Caveolins, Cav-1 and Cav-2, in skeletal muscle development (mouse), 316 CD11c/CD18, EAE development requires p150/95 (mouse), 2001 CD38, HSC, identification and characterization (rat), 176 CD200, neuronal expression and neurodegeneration ( Wld s mouse), 1695 CDX2 gene , expression controlled by microenvironment, colorectal cancer cells (human and mouse), 733 Cerebral malaria, TLR-independent development of (mouse), 1640 Chagas' disease, galectin-3 induces thymocyte atrophy, T. cruzi infection (mouse), 546 Chemokine ligands CCL3, CCR5 and, in macrophage and fibrocyte regulation, PF (mouse), 843 CCL21, PF abrogated by CCR7 or (SCID mouse), 1152 CXCL1 and CXCL2 effectors for HUS, 526 CXCL16 inhibition and effect on anti-GBM-associated glomerulonephritis, 1485 Chemokine receptors CCR5, CCL3 and, in macrophage and fibrocyte regulation, PF (mouse), 843 CCR7, PF abrogated by CCL21 or (SCID mouse), 1152 CCR5 deficiency enhances NK T cell trafficking and activation, T cell-mediated hepatitis (mouse), 1975 CCR6 expression and development of ILF, B cells (mouse), 1229 Chlamydia pneumoniae , cardiomyocyte infection by, correlated with AMI, 33 Chondrocytes, pseudoachondroplasia, matrix structure in RER, 293 Chondroitin sulfate proteoglycan, in adherence of P. falciparum -infected erythrocytes, human placenta, 1989 Choroidal neovascularization, IL-6R-mediated STAT3 activation promotes (mouse), 2149 Chromatin different organization in benign and malignant cells (letter), 787 tumor plasticity, epigenetic reversion of breast cancer phenotype, 1739 Chromosomal instability, aneuploidy in early stages of intestinal adenomas (mouse), 377 Chronic heart failure, oxidative phenotype protects myofibers from insult by (mouse), 599 Cigarette smoke, AhR and RelB in inflammatory responses to (mouse), 855 CL. see Cutaneous leishmaniasis Claudin-5, hypoxia disrupts barrier function of neural blood vessel ECs via (mouse), 1389 Claudin-7, regulates E-cadherin expression and invasion of esophageal SCC cells, 709 Clostridium sordellii , lethal toxin from, induces major increase in lung vascular permeability (mouse), 1003 CNV. see Choroidal neovascularization Col4a2 gene , expression regulated by SOX9, mesangial cells, 1854 Collagen MMPs and cathepsins in degradation, abdominal aortic aneurysms, 809 type VII, CMP subdomain pathogenic for EBA, 2009 Colon cancer, human cells, orthotopic microinjection induces metastatic sites (nude mouse), 1077 Colorectal cancer CDX2 gene expression controlled by microenvironment (human and mouse), 733 micrometastases, role of perinecrotic hypoxia in outgrowth of (mouse), 1379 Complement alternative pathway, in ANCA-mediated disease (mouse), 52 C1q reduces early atherosclerosis (LdlR-deficient mosue), 416 Contact hypersensitivity, chronic E-selectin during responses (mouse), 1649 platelets in leukocyte recruitment (mouse), 2019 Cornea, angiogenesis, bFGF-induced, proangiogenic role of ephrin-B1/EphB1 (mouse), 764 Corticotropin-releasing hormone receptors, type 1α, in mediating responses, chronically inflamed synovial tissue, 1121 C1q, reduces early atherosclerosis (LdlR-deficient mosue), 416 Crambene, apoptosis induction by, protects against acute pancreatitis (mouse), 1521 CRHRs. see Corticotropin-releasing hormone receptors Cryoglobulinemia, hepatitis and, thymic stromal lymphopoietin in (transgenic mouse), 981 Cryptococcus neoformans , during ABPM, effect of GM-CSF (mouse), 1028 CSPG. see Chondroitin sulfate proteoglycan Cutaneous leishmaniasis, FasL and TRAIL in epidermal apoptosis and skin ulceration, 227 Cyclooxygenase 2, reduction counters ovarian morphological aging (Wv mouse), 1325 Cyclosome, tumor overexpression of oncogenic regulators and substrates of APC/C, 1793 Cystine/glutamate antiporter, glutamate suppresses osteoclastogenesis via (mouse), 1277 DAF. see Decay-accelerating factor Darbepoetin-α, attenuation of inflammation and apoptosis by, acute liver failure (mouse), 1954 DCM. see Dilated cardiomyopathy Decay-accelerating factor, ameliorates systemic autoimmune disease (MRL/lpr mouse), 1258 Decidua human, KAI1 expression in cells of, 126 thrombin induces sFlt-1 expression, decidual cells, 1398 Decorin, fibrillin-1 regulation mediated by, involves IGF-1R and mTOR, kidney cells, 301 Demyelination, microglia recruitment activation and proliferation response to (mouse), 1713 Diabetes BL5923 as potential therapy for nephropathy (db/db mouse), 1267 eNOS deficiency and susceptibility to diabetic nephropathy (mouse), 1473 wound healing impaired by decrease in macrophage number and activation (mouse), 1178 Diet, low in glycotoxins, oxidative stress reduced after exposure to (mouse), 1893 Diffuse large B-cell lymphomas, vascularity and VEGF and VEGFRs in, 1362 Dilated cardiomyopathy, B cells in switch from C protein-induced myocarditis to (rat), 43 DLBCL. see Diffuse large B-cell lymphomas DLX4 gene, induces VEGF and FGF-2, role in ovarian tumorigenicity, 1594 DMBT1 gene, modifies mammary tumor and breast cancer risk (mouse and human), 2030 DMT1. see DNA methyltransferase 1 DNA, mitochondrial, altered by mitochondrial TK2 overexpression (mouse), 865 DNA methyltransferase 1, RB dysregulation causes overexpression of, via MAD2-mediated APC inhibition, 1585 Duchenne muscular dystrophy, free radical scavengers modulate p38 and MMP activity in diaphragm muscle (dystrophin-deficient Mdx mouse), 633 EA. see Experimental arthritis EAE. see Experimental autoimmune encephalomyelitis EAMG. see Experimental autoimmune myasthenia gravis EAT. see Experimental autoimmune thyroiditis EBA. see Epidermolysis bullosa acquisita EIU. see Endotoxin-induced uveitis Elastic fibers, homeostasis, vagina (fibulin-5 KO mouse), 578 Encephalitis, viral, pathology with CNS-specific autoantibodies (mouse), 557 Endometriosis, aberrant leptin expression induced by HIF-1α, endometriotic stromal cells, 590 Endoplasmic reticulum AIMP1 controls retention of gp96 (mouse), 2042 rough, matrix structure in, pseudoachondroplasia chondrocytes, 293 Endothelial cells mitochondrial thioredoxin expression reduces atherosclerotic lesions and improves function of (mouse), 1108 neural blood vessels, hypoxia disrupts barrier function via claudin-5 (mouse), 1389 Endotoxic shock, associated with nitrosative stress, MLCK210 in, (MLCK210-null mouse), 439 Endotoxin-induced uveitis, PKCζ regulates ocular inflammation and apoptosis (rat), 1241 Ephrin-B1, proangiogenic role of ephrin-B1/EphB1, bFGF-induced corneal angiogenesis (mouse), 764 Epidermal growth factor receptor ERK and in induction of mucins 5B and 5AC by PMA, 20 NSCLC lines dependent on, SFK activation promotes survival of, 366 role in ERK 1/2 activation in tPA-induced pancreatic cancer cell proliferation, 1573 Epidermolysis bullosa acquisita, type VII collagen CMP subdomain pathogenic for, 2009 Epithelial cells, intestinal, annexin 2 regulates spreading and wound closure via Rho, 951 Epstein Barr virus HPS related to, RBC Abs trigger RBC phagocytosis by macrophages (rabbit), 1629 LMP-1 regulates TNFR1 and inhibits T cell apoptosis, 1607 ErbB1, differential signaling in SCC vs. BCC, skin, 2089 Erythrocytes adhesion of P. falciparum -infected, role in pregnancy-associated malaria, commentary, 1817 P. falciparum -infected, role of CSPG in adherence of, human placenta, 1989 Erythrophagocytosis, by liver macrophages, steatohepatitis (rabbit), 967 Escherichia coli O157:H7, CXCL1 and CXCL2 effectors for HUS, 526 Estrogen GPR30-dependent PKA in nongenomic effects, liver injury (rat), 1210 nongenomic effects, regulated by GPR30, commentary, 1148 Ewing's sarcoma IFN-γ sensitizes to TRAIL-induced apoptosis via caspase 8, 1917 Notch signaling inhibition induces neural differentiation (xenograft mouse), 1686 Experimental arthritis, adrenomedullin protection from, via TH1 response and Treg cell induction (mouse), 263 Experimental autoimmune encephalomyelitis axonal degeneration in, MS models (mouse), 214 development requires p150/95 (mouse), 2001 M-PLP inhibits autoreactive T cell encephalitogenicity (mouse), 272 microglia recruitment, activation and proliferation response to demyelination (mouse), 1713 neuronal CD200 expression and neurodegeneration ( Wld s mouse), 1695 Experimental autoimmune myasthenia gravis, rapsyn in muscle increases AChR levels (rat), 644 Experimental autoimmune thyroiditis, granulomatous, FLIP expression on thyroid epithelial cells promotes resolution (mouse), 875 Experimental malaria, impairment of capillary density but not oxygen delivery (window chamber model, hamster), 505 Extracellular signal regulated kinases autophagy regulation by, during MPP-induced cell death, 75 EGFR and, in induction of mucins 5B and 5AC by PMA, 20 ERK 1/2, in tPA-induced pancreatic cancer cell proliferation, 1573 PKCε in activation of ERK1/2 and Rac1, hairy cell leukemia, 745 Extravillous trophoblasts, first trimester, increased apoptosis in, risk of preeclampsia, 1903 Eyes, PKCζ regulates ocular inflammation and apoptosis, EIU (rat), 1241 Familial encephalopathy with neuroserpin inclusion bodies, accumulation of mutant neuroserpin precedes development of (mouse), 1305 Fas ligand, in epidermal apoptosis and skin ulceration, CL, 227 FENIB. see Familial encephalopathy with neuroserpin inclusion bodies Fibrillin-1, decorin-mediated regulation involves IGF-1R and mTOR, kidney cells, 301 Fibroblast growth factor, basic, corneal angiogenesis induced by, proangiogenic role of ephrin-B1/EphB1 (mouse), 764 Fibroblast growth factor 4, induced by DLX4 gene, role in ovarian tumorigenicity, 1594 Fibroblast growth factor receptor 2, epigenetic silencing via DNA and histone methylation, pituitary tumor cells, 1618 Fibroblasts human breast, inhibit growth of MCF10AT xenografts (nude mouse), 1064 in modulation of breast cancer sensitivity to tamoxifen, 1546 Fibrocytes, CCL3 and CCR5 in regulation of macrophages and, PF (mouse), 843 Fibronectin α4β1 integrin interactions with, regulate MMP-9 expression, steatotic liver I/R injury (rat), 567 promotes luteinized granulosa cell survival, 1561 Fibulin-2, breast cancer progression associated with loss of, 1535 Fibulin-5, elastic fiber homeostasis, vagina (fibulin-5 KO mouse), 578 FLIP, expression on thyroid epithelial cells promotes G-EAT resolution (mouse), 875 Focal adhesion kinase, controls epidemal barrier homeostasis via Na + /H + exchanger 1 (mouse), 2055 Free radical scavengers, modulate p38 and MMP activity in diaphragm muscle (dystrophin-deficient Mdx mouse), 633 FTY720, induces differentiation via S1P 3 and Smad3, myofibroblasts, 281 G-EAT. see Granulomatous experimental autoimmune thyroiditis G-protein-coupled receptor 30 mediates estrogen's nongenomic effects, commentary, 1148 PKA dependent on, in nongenomic effects of estrogen, liver injury (rat), 1210 β-1,4-Galactosyltransferase-I, in development of IgA nephropathy (mouse), 447 Galectin-3, induces thymocyte atrophy, T. cruzi infection (mouse), 546 Gelatinase B. see Matrix metalloproteinases, MMP-9 Gene therapy, rapsyn expression in muscle increases AChR levels, EAMG (rat), 644 Glioblastoma, primary and secondary, genetic pathways, review, 1445 Glomerulonephritis alternative complement pathway in ANCA-mediated disease (mouse), 52 anti-GBM-associated, effect of CXCL16 inhibition, 1485 Glucocorticoid receptor, signaling in T cells affects thymocyte apoptosis and adaptive immune responses (rat and mouse), 1041 Glutamate, suppresses osteoclastogenesis via cystine/glutamate antiporter (mouse), 1277 Glyceryl trinitrate, inhibits hypoxia/reoxygenation-induced apoptosis, syncytiotrophoblasts, 909 Glycogen synthase kinase 3, lithium reduces tau phosphorylation (transgenic mouse), 1669 Glycotoxins, oxidative stress reduced after exposure to low diet in (mouse), 1893 Gottlieb, Leonard S., in memoriam, 1135 gp96, AIMP1 controls ER retention of (mouse), 2042 GPR30. see G-protein-coupled receptor 30 GR. see Glucocorticoid receptor Granulocyte-macrophage colony-stimulating factor, in C. neoformans infection during ABPM (mouse), 1028 Granulomatous experimental autoimmune thyroiditis, FLIP expression on thyroid epithelial cells promotes resolution (mouse), 875 Granulosa cells, luteinized, survival promoted by luteogenic hormones via VEGF and integrins, 1561 Hairy cell leukemia, PKCε in activation of ERK1/2 and Rac1, 745 Heart aberrant expression of microRNAs in cardiac hypertrophy (mouse), 1831 Smad5 required for cardiac homeostasis (mouse), 1460 vimentin autoantibodies accelerate cardiac allograft rejection (mouse), 1415 wound healing after myocardial injury impaired by macrophage depletion (mouse), 818 Heat shock protein, gp96, AIMP1 controls ER retention of (mouse), 2042 Hedgehog protein, promotes survival via Bcl II, medulloblastomas, 347 Heme oxygenase-1, I/R injury attenuated by statins via induction of, macrophages (rat), 1192 Hemolytic uremic syndrome, CXCL1 and CXCL2 effectors for, 526 Hemophagocytic syndrome, EBV-associated, RBC Abs trigger RBC phagocytosis by macrophages (rabbit), 1629 Heparan sulfate proteoglycans, become L-selectin and MCP-1 ligands, renal I/R (rat and mouse), 1865 Hepatic stellate cells CD38 identification and characterization (rat), 176 human, VEGF and Ang-1 stimulate migration of (rat and human), 1942 Hepatitis cryoglobulinemia and, thymic stromal lymphopoietin in (transgenic mouse), 981 T cell-mediated, CCR5 deficiency enhances NK T cell trafficking and activation (mouse), 1975 Hepatitis C virus, replication in transfected and serum-infected human fetal hepatocytes, 478 Hepatocellular carcinomas, human, ABCG2 and cancer cell hierarchy, 1750 Hepatocytes, transfected and serum-infected human fetal, HCV replication in, 478 Heterotropic bone, hypoxic adipocytes in early formation of (NOD-SCID mouse), 620 HIFs. see Hypoxia inducible factors Homeobox genes, DLX4 , induces VEGF and FGF-2, role in ovarian tumorigenicity, 1594 Homocysteine, gestational vitamin B deficiency causes apoptosis associated with, brain (rat), 667 HPS. see Hemophagocytic syndrome HSCs. see Hepatic stellate cells HSPGs. see Heparan sulfate proteoglycans HUS. see Hemolytic uremic syndrome Hyaluronan, accelerates angiogenesis via stroma cells, Neu-induced mammary tumors (mouse), 1086 Hydrogen sulfide, protective affect on neointima-hyperplasia, carotid arteries (rat), 1406 Hyperhomocysteinemia, gestational vitamin B deficiency causes homocysteine-associated apoptosis, brain (rat), 667 Hypertension, mitochondrial thioredoxins and, commentary, 805 Hypoxia chronic, human placental HIF-1α expression and clinical outcomes in, 2171 disrupts barrier function of neural blood vessel ECs via claudin-5 (mouse), 1389 perinecrotic, in growth of colorectal cancer micrometastasis (mouse), 1379 Hypoxia-inducible factor-1α aberrant leptin expression induced by, endometriotic stromal cells, 590 HIF-2α and, in PKD (rat and human), 830 human placenta, expression and clinical outcomes in chronic hypoxia, 2171 mediates insulin affects, pancreatic cancer cells, 469 perinecrotic hypoxia in colorectal cancer metastatic growth (mouse), 1379 ILF. see Isolated lymphoid follicles Immune responses, Th1 cells promote bone resorption caused by P. gingivalis (mouse), 203 Immunoglobulin A nephropathy B cells in renal interstitial inflammation, 457 development in β4 GalT-I deficiency (mouse), 447 Immunoglobulin receptors, FcγRI, CRP affinity towards, 755 Inflammation AhR and RelB responses to cigarette smoke (mouse), 855 cathepsin G after renal I/R injury (mouse), 930 colonic, role of iNOS in (mouse), 490 CRH-R1α in mediating responses, chronically inflamed synovial tissue, 1121 host response promotes tumor metastasis, liver, 1781 intrapulmonary ricin delivery triggers glomerular damage and (mouse), 1497 RA-associated, MyD88 and Mal/TIRAP in, 518 renal interstitial, B cells in, 457 TNF-α in Rgmc repression during (mouse), 497 Insulin, effects mediated by HIF-1α, pancreatic cancer cells, 469 Insulin-like growth factor-1, in gastric ulcer healing (rat), 1219 Insulin-like growth factor 1 receptor, in decorin-mediated fibrillin-1 regulation, kidney cells, 301 Integrins α7β1, effect on LGMD2F (mouse), 609 α4β1, interactions with FN regulate MMP9 expression, steatotic liver I/R injury (rat), 567 α 5 β 1 and α v β 3 , promote luteinized granulosa cell survival, 1561 EAE development requires p150/95 (mouse), 2001 αvβ6, regulates renal fibrosis and inflammation (Alport mouse), 110 Interferon-γ sensitizes Ewing's sarcoma to TRAIL-induced apoptosis via caspase 8, 1917 TNF-α and, regulate Aβ plaque deposition and β-secretase expression (APP/GRKO mouse), 680 Interleukin 10 deficiency, wound healing accelerated in (mouse), 188 role during infection with RF spirchete B. turicatae (mouse), 251 Interleukin 13, in PKCζ regulation of ocular inflammation and apoptosis, EIU (rat), 1241 Interleukin 6 receptor, STAT3 activation mediated by, promotes CNV (mouse), 2149 Interleukin-1 receptor 1, essential for control of cerebral listeriosis (mouse), 990 Interstitial nephritis, B cells in renal interstitial inflammation, 457 Intestinal adenomas, chromosomal instability with aneuploidy in early stages of (mouse), 377 Ischemia/reperfusion injury attenuated by statins via HO-1 induction, macrophages (rat), 1192 renal, HSPGs become L-selectin and MCP-1 ligands (rat and mouse), 1865 Islet cells, pancreatic, islet β-cell-specific T cell homing mechanisms in destruction of (mouse), 240 Isolated lymphoid follicles, CCR6 expression and development of, B cells (mouse), 1229 JC virus, survivin activation by, in PML, 1291 KAI1, expression in human decidual cells, 126 Keratinocyte growth factor, KGFR and, enhanced expression correlates with venous invasion, pancreatic cancer, 1964 Keratinocyte growth factor receptor, KGF and, enhanced expression correlates with venous invasion, pancreatic cancer, 1964 Kidneys B cells in renal interstitial inflammation, 457 cathepsin G in inflammation and tissues after I/R injury (mouse), 930 decorin-mediated fibrillin-1 regulation involves IGF-1R and mTOR, 301 diabetic nephropathy, BL5923 as potential therapy (db/db mouse), 1267 effect of AT1R and AT2R on podocytes, glomerular capillary wall (rat), 1841 eNOS deficiency and susceptibility to diabetic nephropathy (mouse), 1473 eNOS deficiency causes focal renal injury (mouse), 87 hemodynamic, inflammatory, and apoptotic responses to LPS (HO-1 −/− mouse), 1820 I/R injury, HSPGs become L-selectin and MCP-1 ligands (rat and mouse), 1865 intrapulmonary ricin delivery triggers inflammatory response and glomerular damage (mouse), 1497 rosuvastatin prevents inflammation and fibrosis (SHRSP rat), 1165 αvβ6 integrin regulates renal fibrosis and inflammation (Alport mouse), 110 Kupffer cells, erythrophagocytosis by, steatohepatitis (rabbit), 967 L neutral amino acid transporter 3, characterization of (mouse), 888 Lactadherin, role in Alzheimer's disease, 921 Laminin-511, role in breast cancer metastases (mouse), 2135 LAT3. see L neutral amino acid transporter 3 Latent membrane protein-1, EBV, regulates TNFR1 and inhibits T cell apoptosis, 1607 Leishmania major , FasL and TRAIL in epidermal apoptosis and skin ulceration, CL, 227 Leptin aberrant expression induced by HIF-1α, endometriotic stromal cells, 590 TLR expression and responsiveness dependent on, preadipocytes and adipocytes (mouse), 1931 Leukocytes, platelets in recruitment of, chronic contact hypersensitivity (mouse), 2019 LGMD2F. see Limb girdle muscular dystrophy type 2F Limb girdle muscular dystrophy type 2F, effect of α7β1 integrin (mouse), 609 Lipopolysaccharide, hemodynamic, inflammatory, and apoptotic responses, kidneys (HO-1 −/− mouse), 1820 Listeria monocytogenes , IL-1R1 essential for control of cerebral listeriosis (mouse), 990 Lithium, reduces tau phosphorylation (transgenic mouse), 1669 Liver acuter failure, darbepoetin-α attenuation of inflammation and apoptosis (mouse), 1954 CCR5 deficiency enhances NK T cell trafficking and activation, T cell-mediated hepatitis (mouse), 1975 erythrophagocytosis by liver macrophages, steatohepatitis (rabbit), 967 host inflammatory response promotes tumor metastasis, 1781 steatotic I/R injury fibronectin-α4β1 integrin interactions regulate MMP-9 expression (rat), 567 traumatic injury, GPR30-dependent PKA in nongenomic effects of estrogen (rat), 1210 LMP-1. see Latent membrane protein-1 Lungs Aggrus/podoplanin promotes metastases, mouse, 1337 C.sordellii lethal toxin induces major increase in vascular permeability (mouse), 1003 GM-CSF in C. neoformans infection during ABPM (mouse), 1028 molecular pathology of SARS, 538 PF, CCL3 and CCR5 in macrophage and fibrocyte regulation (mouse), 843 tumor signaling changes macrophage phenotype, primary lung tumorigenesis (A/J mouse), 693 Lymphangiogenesis metastases and, melanoma (mouse), 774 VEGF-D in metastasis and, β-cell carcinogenesis (Rip1Tag2 mouse), 1348 Lymphopoietin, thymic stromal, in cryoglobulinemia and hepatitis (transgenic mouse), 981 M-PLP. see Mannosylated myelin peptide of proteolipid protein Macrophages CCL3 and CCR5 in regulation of fibrocytes and, PF (mouse), 843 depletion impairs wound healing after myocardial injury (mouse), 818 enhanced in ACE, melanoma-resistance and (mouse), 2122 infiltrating, statins attenuate IR injury via HO-1 induction (rat), 1192 interstitial, BL5923 inhibits recruitment of, diabetic nephropathy (db/db mouse), 1267 liver, erythrophagocytosis by, steatohepatitis (rabbit), 967 number and activation of, effect on lymphatic formation and diabetic wound healing (mouse), 1178 RBC Abs trigger RBC phagocytosis by, EBV-related HPS (rabbit), 1629 tumor signaling changes phenotype of, primary lung tumorigenesis (A/J mouse), 693 MAD-2, RB dysregulation causes DMT1 overexpression via APC inhibition mediated by, 1585 Mal/TIRAP, MyD88 and, in inflammatory processes during RA, 518 Malaria cerebral, TLR-independent development of (mouse), 1640 experimental, impairment of capillary density but not oxygen delivery (window chamber model, hamster), 505 pregnancy-associated, adhesion of P. falciparum -infected erythrocytes in, commentary, 1817 Mammary tumors DMBT1 gene modifies risk of breast cancer and (mouse and human), 2030 Neu-induced, hyaluronan production accelerates angiogenesis via stroma cell recruitment (mouse), 1086 Maneb, α-synucleinopathy exacerbated by exposure to pesticides (A53Tg mouse), 658 Mannosylated myelin peptide of proteolipid protein, inhibits autoreactive T cell encephalitogenicity, EAE (mouse), 272 Mast cells, control of P. aeruginosa skin infections dependent on (mouse), 1910 Matrix metalloproteinases cathepsins and, in collagen degradation, abdominal aortic aneurysms, 809 membrane type 1, prostate cancer-associated, 2100 MMP-9 expression, invasive and noninvasive pituitary adenomas, 356 MMP-9 expression regulated by fibronectin-α4β1 integrin interactions, steatotic liver I/R injury (rat), 567 modulated by free radical scavengers in diaphragm muscle (dystrophin-deficient Mdx mouse), 633 MCI. see Mild cognitive impairment Medulloblastomas, Hedgehog promotes survival via Bcl II, 347 Melanoma lymph angiogenesis and metastases (mouse), 774 resistance to, ACE-enhanced macrophages (mouse), 2122 Membrane type 1-matrix metalloproteinase, prostate cancer-associated, 2100 Mesangial cells, Col4a2 gene expression regulated by SOX9, 1854 Metastasis progression of breast cancer, laminin-511 in (mouse), 2135 pulmonary, promoted by Aggrus/podoplanin, mouse, 1337 tumor cell transendothelial passage in absorbing lymphatic vessel, prostate cancer (mouse), 334 VEGF-D in lymphangiogenesis and, β-cell carcinogenesis (Rip1Tag2 mouse), 1348 1-Methyl-4-phenylpyridinium, ERK regulation of autophagy during cell death induced by, 75 Microenvironments, CDX2 gene expression controlled by, colorectal cancer cells (human and mouse), 733 Microglia, recruitment, activation and proliferation response to demyelination (mouse), 1713 Micrometastases, colorectal cancer, role of perinecrotic hypoxia in outgrowth of (mouse), 1379 MicroRNAs, aberrant expression of, cardiac hypertrophy model (mouse), 1831 Mig-7. see Migration-inducing protein 7 Migration-inducing protein 7 induces invasion and vessel-like structure formation (mouse), 1763 role in vasculogenic mimicry, commentary, 1454 Mild cognitive impairment, caspase-6 activation in aging and, 1200 Mitochondria, TK2 overexpression alters mtDNA and mitochondrial peptides (mouse), 865 Mitogen activated protein kinases, stress-activated, human placental response to oxidative stress involves NF-κB, p38 and, 1511 MLCK210, role in endotoxic shock associated with nitrosative stress (MLCK210-null mouse), 439 Monocyte chemoattractant protein 1, HSPGs as ligands for L selectin and, renal I/R (rat and mouse), 1865 MPP. see 1-Methyl-4-phenylpyridinium MS. see Multiple sclerosis mTOR. see Target of rapamycin Mucins, 5B and 5AC, EGFR and ERK in induction by PMA, 20 Multiple sclerosis ADEM and, autoimmunity model, commentary, 436 axonal degeneration in EAE and TMEV models of (mouse), 214 murine model, microglia recruitment, activation and proliferation response to demyelination (mouse), 1713 Muscular dystrophy Duchenne type, free radical scavengers modulate p38 and MMP activity in diaphragm muscle (dystrophin-deficient Mdx mouse), 633 limb girdle type 2F, effect of α7β1 integrin (mouse), 609 MyD88, Mal/TIRAP and, in inflammatory processes during RA, 518 Myeloid cells, Notch1 ectodomain overexpression induces vascular malformations (mouse), 399 Myocarditis, C protein-induced, B cells in switch to DCM (rat), 43 Myocilin, induces Russell bodies and causes apoptosis, POAG, 100 Myofibroblasts FTY720 induces differentiation via S1P 3 and Smad3, 281 functions and origins, perspectives, 1807 Myogenesis, VPCs capable of induction of vasculogenesis and, human fetal aorta, 1879 Natural killer cells, CCR5 deficiency enhances trafficking and activation, T cell-mediated hepatitis (mouse), 1975 Neointimal hyperplasia, inhibited by PEDF by blocking NADPH oxidase-mediated ROS (rat), 2159 Neovascularization, choroidal, promoted by IL-6R-mediated STAT3 activation (mouse), 2149 Nephropathy, diabetic, BL5923 as potential therapy (db/db mouse), 1267 Nerves, Notch signaling inhibition induces neural differentiation, Ewing's sarcoma (xenograft mouse), 1686 Neuroblastomas, Bmi-1 essential for tumorigenicity (mouse), 1370 Neuroserpin, mutant, accumulation precedes development in FENIB (mouse), 1305 Neutrophil elastase, deficiency, in resistance to bleomycin-induced pulmonary fibrosis (mouse), 65 Nitric-oxide synthase endothelial, deficiency and susceptibility to diabetic nephropathy (mouse), 1473 endothelial, deficiency causes focal renal injury (mouse), 87 inducible, in colonic inflammation (mouse), 490 Noggin, determines osteoblast responses, bone metastases (mouse), 160 Non-small cell lung cancer, SFK activation, promotes survival of EGFR-dependent lines, 366 Notch, signaling inhibition induces neural differentiation, Ewing's sarcoma (xenograft mouse), 1686 Notch1, ectodomain overexpression induces vascular malformations, myeloid cells (mouse), 399 Nrf2, deficiency, vacuolar leukoencephalopathy with astrogliosis (mouse), 2068 NSCLC. see Non-small cell lung cancer Nuclear factor-κB, human placental response to oxidative stress involves p38, stress-activated MAPK and, 1511 Nucleoside reverse transcriptase inhibitors, mitochondrial toxicity anf, 865 Obituaries Leonard S. Gottlieb, 1135 Robert William Wissler, 791 Osteoblasts Noggin determines responses, bone metastases (mouse), 160 Runx2 overexpression regulates PTH activity (mouse), 1676 Osteoclastogenesis, suppressed by glutamate via cystine/glutamate antiporter (mouse), 1277 Osteoclasts, in health and disease, Rous-Whipple Award Lecture, 427 Ovarian cancer DLX4 gene induces VEGF and FGF-2, role in ovarian tumorigenicity, 1594 SPARC inhibits integrin-mediated adhesion and GF-dependent survival, 1054 Ovaries, COX-2 reduction counters morphological aging (Wv mouse), 1325 Oxidative stress human placental response to, involves NF-κB, p38 and stress-activated MAPK, 1511 reduced after exposure to low glycotoxin diet (mouse), 1893 p38 human placental response to oxidative stress involves NF-κB, stress-activated MAPK and, 1511 modulated by free radical scavengers in diaphragm muscle (dystrophin-deficient Mdx mouse), 633 p150/95, required for EAE development (mouse), 2001 Pancreatic cancer cells, effects of insulin mediated by HIF-1α, 469 enhanced KGFR and KGF expression correlates with venous invasion, 1964 tPA induces proliferation, role of ERK1/2 activation via annexin 2 and EGFR, 1573 Pancreatitis, acute, apoptosis induction by crambene protects against (mouse), 1521 Paraquat, α-synucleinopathy exacerbated by exposure to pesticides (A53Tg mouse), 658 Parathyroid hormone, activity regulated by Runx2 overexpression, osteoblasts (mouse), 1676 Parkinson's disease, selective vulnerability and cell death, commentary, 16 PBX1. see Pre-B-cell leukemia transcription factor 1 Peroxisome proliferator-activated receptor γ, activation promotes T lymphoma cell survival, 722 PF. see Pulmonary fibrosis Phorbol 12-myristate 13-acetate, EGFR and ERK in induction of 5B and 5AC mucins by, 20 Photoreceptors, retinal, Prp106–126 prion protein toxicity to (pig and human), 1314 Pigment epithelium-derived factor, inhibits neointimal hyperplasia by blocking NADPH oxidase-mediated ROS (rat), 2159 Pituitary adenomas, invasive and noninvasive, MMP-9 expression in, 356 Pituitary cancer, FGFR2, epigenetic silencing via DNA and histone methylation, 1618 PKD. see Polycystic kidney disease Placenta human, response to oxidative stress involves NF-κB, p38 and stress-activated MAPK, 1511 RASSF1A hypermethylation in (human and Rhesus monkey), 941 Plasminogen activator, tissue type, pancreatic cancer cell proliferation induced by, role of ERK1/2 activation via annexin 2 and EGFR, 1573 Plasmodium falciparum adhesion of erythrocytes infected by, role in pregnancy-associated malaria, commentary, 1817 erythrocytes infected with, role of CSPG in adherence of, human placenta, 1989 Platelets, leukocyte recruitment and, in chronic contact hypersensitivity (mouse), 2019 PMA. see Phorbol 12-myristate 13-acetate PML. see Progressive multifocal leukoencephalopathy Podocytes, effect of AT1R and AT2R on, glomerular capillary wall (rat), 1841 Podoplanin. see Aggrus Polycystic kidney disease, HIFs in (rat and human), 830 Pomt1 gene, expression in brain and muscle, relationship to WWS (mouse), 1659 Porphyromonas gingivalis , Th1 cell Immune responses promote bone resorption caused by (mouse), 203 PPAR-γ. see Peroxisome proliferator-activated receptor γ Pre-B-cell leukemia transcription factor 1, regulates VCP expression, 152 Preadipocytes, leptin-dependent TLR expression and responsiveness, adipocytes and (mouse), 1931 Prednisolone, calcitonin and, effects on bone and experimental arthritis (rat), 1018 Preeclampsia, risk of, increased apoptosis in first trimester extravillous trophoblasts and, 1903 Pregnancy CSPG in adherence of P. falciparum -infected erythrocytes, human placenta, 1989 human placental HIF-1α expression and clinical outcomes in chronic hypoxia, 2171 increased apoptosis in first trimester EVTs, risk of preeclampsia, 1903 malaria associated with, adhesion of P. falciparum -infected erythrocytes in, 1817 thrombin induces sFlt-1 expression, decidual cells, 1398 Primary open-angle glaucoma, myocilin induces Russell bodies and causes apoptosis, 100 Prion proteins, Prp106–126, toxicity to retinal photoreceptors (pig and human), 1314 Progressive multifocal leukoencephalopathy, survivin activation by JCV, 1291 Prostate cancers MT1-MMP associated with, 2100 tumor cell transendothelial passage in absorbing lymphatic vessel (mouse), 334 Protein kinases PKA, GPR30-dependent, in nongenomic effects of estrogen, liver injury (rat), 1210 PKCδ knockout model, inhibition of asbestos-induced bronchiolar proliferation in (mouse), 140 PKCε in ERK1/2 and Rac1 activation, hairy cell leukemia, 745 PKCζ regulates ocular inflammation and apoptosis, EIU (rat), 1241 Pseudoachondroplasia, chondrocytes, matrix structure in RER, 293 Pseudomonas aeruginosa , mast cell dependent control of skin infections (mouse), 1910 Pulmonary fibrosis abrogated by CCL21 or CCR7 (SCID mouse), 1152 bleomycin-induced, neutrophil elastase deficiency and resistance to (mouse), 65 CCL3 and CCR5 in macrophage and fibrocyte regulation (mouse), 843 Rac1, PKCε in activation of ERK1/2 and, hairy cell leukemia, 745 Rapsyn, expression in muscle increases AChR levels, EAMG (rat), 644 RASSF1A gene, hypermethylation in placenta (human and Rhesus monkey), 941 Reactive oxygen species, NADPH oxidase-mediated, neointimal hyperplasia inhibited by PEDF by blocking (rat), 2159 Red blood cells, Abs to, trigger RBC phagocytosis by macrophages. EBV-related HPS (rabbit), 1629 Rejection, cardiac allografts, accelerated by vimentin autoantibodies (mouse), 1415 Relapsinig fever, B. turicatae spirchete, IL-10 during infection with (mouse), 251 RelB, AhR and, in inflammatory responses to cigarette smoke (mouse), 855 Repulsive guidance molecule c, repression during inflammation involves TNF-α (mouse), 497 RER. see Rough endoplasmic reticulum Retina, Prp106–126 prion protein toxicity to photoreceptors (pig and human), 1314 Retinoblastoma, dysregulation causes DMT1 overexpression via MAD2-mediated APC inhibition, 1585 Rgmc. see Repulsive guidance molecule c Rheumatoid arthritis, MyD88 and Mal/TIRAP in inflammatory processes during, 518 Rho, annexin 2 regulates intestinal epithelial cell spreading and wound closure via, 951 Ricin, intrapulmonary delivery triggers inflammatory response and glomerular damage (mouse), 1497 Rosuvastatin, prevents kidney inflammation and fibrosis (SHRSP rat), 1165 Rough endoplasmic reticulum, matrix structure in, pseudoachondroplasia chondrocytes, 293 Rous-Whipple Award Lecture, osteoclasts in health and disease, 427 Runx2, overexpression regulates PTH activity, osteoblasts (mouse), 1676 Russell bodies, induced by myocilin, POAG, 100 SARS. see Severe acute respiratory syndrome β-Secretase, IFN-γ and TNF-α regulate plaque deposition and expression of (APP/GRKO mouse), 680 Secreted protein acidic and rich in cysteine, inhibits integrin-mediated adhesion and GF-dependent survival, ovarian cancer, 1054 E-Selectin, in chronic contact hypersensitivity responses (mouse), 1649 L-Selectin, HSPGs as ligands for MCP-1 and, renal I/R (rat and mouse), 1865 Sepsis, pathophysiology of, biological perspectives, 1435 Severe acute respiratory syndrome molecular pathology in lungs, 538 pathology and pathogenesis, review, 1136 SFKs. see Src-family kinases Signal transducer and activator of transcription-3, IL-6R-mediated activation, promotes CNV (mouse), 2149 Skeletal muscle, development, Cav-1 and Cav-2 in (mouse), 316 Skin differential ErbB1 signaling in SCC vs. BCC, 2089 FAK controls epidemal barrier homeostasis via Na + /H + exchanger 1 (mouse), 2055 mast cell-dependent control of P. aeruginosa infections (mouse), 1910 Smad3, FTY720 induces differentiation via S1P 3 and, myofibroblasts, 281 Smad5, required for cardiac homeostatis (mouse), 1460 Smoking, AhR and RelB in inflammatory responses to cigarette smoke (mouse), 855 Sodium/hydrogen exchanger 1, FAK controls epidemal barrier homeostasis via (mouse), 2055 Soluble fms-like tyrosine kinase-1, thrombin induces expression of, decidual cells, 1398 SOX9. see SRY-related HMG box 9 S1P 3 . see Sphingosine 1-phosphate SPARC. see Secreted protein acidic and rich in cysteine Sperm, abnormalities in ASM deficiency (knockout mouse), 2077 Sphingosine 1-phosphate, FTY720 induces differentiation via Smad3 and, myofibroblasts, 281 Squamous cell carcinoma differential ErbB1 signaling in BCC vs. , skin, 2089 esophageal cells, claudin-7 regulates E-cadherin expression and invasion of, 709 Src-family kinases, activation, promotes survival of EGFR-dependent NSCLC lines, 366 SRY-related HMG box 9, Col4a2 gene expression regulated by, mesangial cells, 1854 Statins attenuate IR injury via HO-1 induction, macrophages (rat), 1192 rosuvastatin, prevents kidney inflammation and fibrosis (SHRSP rat), 1165 Steatohepatitis, erythrophagocytosis by liver macrophages (rabbit), 967 Stem cells, bone marrow, fate after transplantation into testes (mouse), 899 Survivin, activation by JCV, in PML, 1291 Syncytiotrophoblasts, glyceryl trinitrate inhibits hypoxia/reoxygenation-induced apoptosis, 909 α-Synuclein, calpain-cleavage of, 1725 α-Synucleinopathy, exacerbated by exposure to pesticides (A53Tg mouse), 658 Systemic lupus erythematosis, murine model of, DAF ameliorates systemic autoimmune disease (MRL/lpr mouse), 1258 T cell lymphomas, PPAR-γ activation promotes cell survival, 722 T cells autoreactive, M-PLP inhibits encephalitogenicity, EAE (mouse), 272 EBV LMP-1 regulates TNFR1 and inhibits apoptosis, 1607 GR signaling affects thymocyte apoptosis and adaptive immune responses (rat and mouse), 1041 islet β-cell-specific, homing mechanisms in pancreatic islet destruction (mouse), 240 NK, response in adoptive transfer model of atherosclerosis (mouse), 1100 regulatory, adrenomedullin protection from EA via (mouse), 263 T helper 1 cells adrenomedullin protection from EA via (mouse), 263 immune responses by, promote bone resorption caused by P. gingivalis (mouse), 203 Tamoxifen, breast cancer sensitivity to, fibroblasts in modulation of, 1546 Target of rapamycin, mammalian, in decorin-mediated fibrillin-1 regulation, kidney cells, 301 Tau, phosphorylation of, reduced by lithium (transgenic mouse), 1669 Teitelbaum, Steven L., Rous-Whipple Award Lecture, 427 Testes, bone marrow stem cell fate after transplantation into (mouse), 899 Theiler's murine encephalomyelitis virus, axonal degeneration in, MS models (mouse), 214 Thioredoxins, mitochondrial expression improves EC function and reduces atherosclerotic lesions (mouse), 1108 hypertension and, commentary, 805 Thrombin, induces sFlt-1 expression, decidual cells, 1398 Thymic stromal lymphopoietin, in cryoglobulinemia and hepatitis (transgenic mouse), 981 Thymidine kinase, mitochondrial, overexpression alters mtDNA and mitochondrial peptides (mouse), 865 Thymocytes, atrophy of, induced by galectin-3, T. cruzi infection (mouse), 546 Thyroid gland, FLIP expression on thyroid epithelial cells promotes G-EAT resolution (mouse), 875 TMEV. see Theiler's murine encephalomyelitis virus Toll-like receptors leptin-dependent expression and responsiveness, preadipocytes and adipocytes (mouse), 1931 TLR2 and TLR4, role of MyD88 and Mal/TIRAP in inflammatory processes during RA, 518 TLR-independent development of cerebral malaria (mouse), 1640 TRAIL. see Tumor necrosis factor-related apoptosis-inducing ligand Transplantation, vimentin autoantibodies accelerate cardiac allograft rejection (mouse), 1415 Trophoblasts, extravillous, first trimester, increased apoptosis in, risk of preeclampsia, 1903 Trypanosoma cruzi , thymocyte atrophy induced by Galectin-3 (mouse), 546 Tumor necrosis factor-α IFN-γ and, regulate Aβ plaque deposition and β-secretase expression (APP/GRKO mouse), 680 in Rgmc repression during inflammation (mouse), 497 in vascular aging (rat), 388 Tumor necrosis factor-α receptor-1, regulated by EBV LMP-1, 1607 Tumor necrosis factor-related apoptosis-inducing ligand in epidermal apoptosis and skin ulceration, CL, 227 IFN-γ sensitizes to Ewing's sarcoma apoptosis via caspase 8, 1917 Tumorigenesis, tumor signaling changes macrophage phenotype, lung (A/J mouse), 693 Tumors invasiveness of esophageal SCC cells, claudin-7 regulates E-cadherin expression and, 709 overexpression of oncogenic regulators and substrates of APC/C, 1793 plasticity, epigenetic reversion of breast cancer phenotype, 1739 transendothelial passage of cells in absorbing lymphatic vessel, prostate cancer (mouse), 334 Ulcers, gastric, IGF-1 in healing (rat), 1219 Uveitis, endotoxin-induced, PKCζ regulates ocular inflammation and apoptosis (rat), 1241 Vacuolar leukoencephalopathy with astrogliosis, Nrf2 deficiency in. (mouse), 2068 Vagina, elastic fiber homeostasis (fibulin-5 KO mouse), 578 Valosin-containing protein gene, expression regulated by PBX1, 152 Vascular endothelial growth factor receptors, vascularity and VEGF and, in DLBCL, 1362 Vascular endothelial growth factors Ang-1 and, stimulate migration of human HSCs (rat and human), 1942 induced by DLX4 gene, role in ovarian tumorigenicity, 1594 promotes luteinized granulosa cell survival, 1561 vascularity and VEGFRs and, in DLBCL, 1362 VEGF-D in lymphangiogenesis and metastasis, β-cell carcinogenesis (Rip1Tag2 mouse), 1348 Vascular progenitor cells, capable of induction of vasculogenesis and, human fetal aorta, 1879 Vasculitis, alternative complement pathway in ANCA-mediated disease (mouse), 52 Vasculogenesis alternative mechanisms, cancer, perspectives, 1 Mig-7 in vasculogenic mimicry, commentary, 1454 Mig-7 induces invasion and vessel-like structure formation (mouse), 1763 Vimentin, autoantibodies to, accelerate cardiac allograft rejection (mouse), 1415 Viral encephalitis, pathology with CNS-specific autoantibodies (mouse), 557 Vitamin B, gestational deficiency causes homocysteine-associated apoptosis, brain (rat), 667 VPCs. see Vascular progenitor cells Walker-Warburg syndrome, Pomt1 expression in brain and muscle, relationship to (mouse), 1659 WAVE3 gene, role in invasion and metastases, breast cancer (mouse and human), 2112 Wissler, Robert William, in memoriam, 791 Wound healing accelerated in IL-10-deficiency (mouse), 188 after myocardial injury, impaired by macrophage depletion (mouse), 818 annexin 2 regulates intestinal epithelial cell spreading and wound closure via Rho, 951 diabetic, impaired by decrease in macrophage number and activation (mouse), 1178 WWS. see Walker-Warburg syndrome