The Clinlical Value of CA19-9 Verses CA125 in Diagnosis of Endometriosis

Objective:To investigate the diagnostic values of CA19-9 and CA125 in the serum for endometriosis.Methods:CA19-9 and CA125 serum levels were determined with RIA in 55 patients with endometriosis and 25 control healthy women.Results:the mean serum levels and positive rate of CA19-9 and CA125 for endometriosis and controls are 27.81 U/mL、43.6%,11.78 U/mL,0 and 24.2 U/mL、36.3%,9.02 U/mL,4.0%,respectively.There is significant difference between the measure result and positive rate of CA19-9 and CA125 for endometriosis group and control(P0.05).The mean serum levels of CA19-9 and CA125 in patients at stages Ⅲ～Ⅳ and Ⅰ～Ⅱ,according to the Revised American Fertility Society(R-AFS) classification,are 42.38 U/mL、57.9%,17.36 U/mL、11.8% and 34.75 U/mL、50.0%,15.3 U/mL、5.9%.The difference of the mean serum levels and positive rate between the groups is significant(P0.05).The sensitivity,specificity and accuracy of CA19-9 and CA125 serum levels in diagnosis of endometriosis are 43.6%,100% and 61.25%;36.3%,96.0% and 55.0%,respectively.Conclusions:Measure the levels of CA19-9 and CA125 in serum can raise the sensitivity of diagnosis for endometriosis.The predictive values of CA19-9 and CA125 seem high only to predict severe(stages Ⅲ and Ⅳ) disease.