Two cases of successful pregnancies after hysteroscopic removal of endometrioid adenocarcinoma grade I, stage IA, in young women with Lynch syndrome.

Ingrid Márton, Vranes HS, Sparac V, Maricic I, Kuna K, Kopjar M
Journal of the Turkish German Gynecological Association · 2014 · doi:10.5152/jtgga.2013.69379 · PMID:24790520 · PMC4004308
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Two young women with Lynch syndrome achieved successful full-term pregnancies following hysteroscopic removal of endometrioid adenocarcinoma, one spontaneously and one via IVF, before undergoing recommended hysterectomy.

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This case report describes two young women with Lynch syndrome who were diagnosed with grade I, stage IA endometrioid adenocarcinoma. Both patients underwent hysteroscopic removal of the tumors and subsequently achieved successful pregnancies. The authors present these cases to illustrate that fertility-sparing management may be a viable option for selected young patients with early-stage disease associated with hereditary non-polyposis colorectal cancer syndrome. This paper is centrally about endometriosis and adenomyosis research in the sense that it addresses uterine pathology involving endometrial tissue, although the primary focus is on malignant transformation within the context of Lynch syndrome rather than benign endometriosis or adenomyosis.

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Abstract

We present two cases of endometrioid adenocarcinoma grade I, FIGO IA (staging according to the International Federation of Gynecology and Obstetrics) in young women, diagnosed within endometrial polyps. Both patients underwent repeated hysteroscopies and multiple biopsies after initial treatment to medroxyprogesterone one 400 mg daily or the insertion of IUD-LND (intrauterine device-levonorgestrel) for three months. In both of them, all histological samples were negative. Both of them decided that they would try to conceive. The first patient conceived spontaneously and the second patient after IVF (in vitro fertilisation) treatment. They both gave birth to full-term infants. Hysterectomy was recommended to both of our patients, and was carried out. Both of the patients fulfilled both Amsterdam II and revised Bethesda criteria for hereditary non-polyposis colorectal cancer (HNPCC).
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Article is only available in PDF format. Show PDF J Turk Ger Gynecol Assoc 2014;15(1):63-66 1. Clinic Of Gynecology And Obstetrics, University Hospital “Sv. Duh”, Zagreb, Croatia 2. Clinic Of Gynecology And Obstetrics, Clinical Medical Centre “Sm”, Zagreb, Croatia 3. Polyclinic Of Gynecology And Obstetrics “Cito”, Split, Croatia 4. Department Of Gynecology And Obstetrics, General Hospital Zabok, Zabok, Croatia No information available. No information available Received Date: 01.06.2013 Accepted Date: 17.08.2013 Article is only available in PDF format. Show PDF

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