A pharmacological rat model of recurrent pelvic pain exhibiting hyperalgesia and depression-like behaviors

Xiaotian Yang, Yajie Qin, Qi Zhao, Huiijin Zhao, Yinyin Ding, Bei Liu, Huifang Zhou
In: iScience · 2026 · vol. 29(4) , pp. 115059 · doi:10.1016/j.isci.2026.115059 · PMID:41890970 · W7133707800
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-05 ⓘ

This study developed a rat model for recurrent pelvic pain, demonstrating hyperalgesia and depression-like behaviors, along with neurochemical and metabolic alterations.

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Abstract

= 0.012). Reduced serotonin with brain-derived neurotrophic factor (BDNF) overexpression was identified in the dorsal root ganglia and serum, along with metabolomic dysregulation of amino acid and arachidonic acid pathways. While not replicating full human PDM pathophysiology, this model captures core features of RPP and affective comorbidity, providing a translational platform for mechanistic and therapeutic research.

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References (33)

SciLite annotations

organisms 32
noordeloos 2009062 noordeloos 2009062 noordeloos 2009062 rodents zitter rats tachyoryctes multicellular animals rodents rattus sp. rodents zitter rats rattus sp. rattus sp. rattus sp. rattus sp. rattus sp. noordeloos 2009062 rattus sp. zitter rats human zitter rats rattus sp. rattus sp. rattus sp. zitter rats rodents rattus sp. rattus sp. human zitter rats zitter rats human
chemicals 61
prostaglandin arachidonic acid progesterone serotonin estradiol water estriol acetate benzoate pentobarbital sodium estrogen nitrogen water sucrose water sucrose water sucrose formaldehyde haematoxylin haematoxylin methanol acetonitrile metabolite estriol acetate benzoate cholesterol lipoprotein lipid serotonin sucrose sucrose steroid steroid fatty acylcarnitine phenylacetic acids amino acid phenylalanine tyrosine tryptophan arginine proline dopamine fatty acid nitric oxide estrogen estradiol sucrose serotonin tryptophan serotonin phenylalanine tyrosine tryptophan monoamine serotonin steroid serotonin estriol acetate benzoate sucrose serotonin amino acid +1 more

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