A pharmacological rat model of recurrent pelvic pain exhibiting hyperalgesia and depression-like behaviors

Xiaotian Yang, Yajie Qin, Qi Zhao, Huiijin Zhao, Yinyin Ding, Bei Liu, Huifang Zhou
In: iScience · 2026 · vol. 29(4) , pp. 115059 · doi:10.1016/j.isci.2026.115059 · PMID:41890970 · W7133707800
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Abstract

= 0.012). Reduced serotonin with brain-derived neurotrophic factor (BDNF) overexpression was identified in the dorsal root ganglia and serum, along with metabolomic dysregulation of amino acid and arachidonic acid pathways. While not replicating full human PDM pathophysiology, this model captures core features of RPP and affective comorbidity, providing a translational platform for mechanistic and therapeutic research.

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last seen: 2026-06-10T17:14:06.276822+00:00
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