Extended Postoperative Ciprofloxacin Prophylaxis for Post-Phacoemulsification Endophthalmitis

Extended Postoperative Ciprofloxacin Prophylaxis for Post-Phacoemulsification Endophthalmitis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Extended Postoperative Ciprofloxacin Prophylaxis for Post-Phacoemulsification Endophthalmitis Suleyman Ciftci This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4232760/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Abstract Purpose: This study investigated the efficacy of extended oral ciprofloxacin prophylaxis in reducing the incidence of endophthalmitis after cataract surgery. Setting : Single-center study conducted at a tertiary health facility. Design: This was a retrospective observational study. Methods: This study was conducted on patients who underwent uncomplicated phacoemulsification surgery. Two cohorts were analyzed: one receiving oral ciprofloxacin twice daily for one week post-surgery and another not receiving ciprofloxacin. The patients who did not receive ciprofloxacin were operated on between June 2013 and October 2019, while the others underwent surgery between June 2011 and April 2021. Endophthalmitis incidence, patient demographics, and surgical variables were assessed between the two groups. Statistical analyses included chi-square tests, Fisher’s exact tests, logistic regression, and Kaplan‒Meier estimates. Results: Out of 1172 eyes (1015 patients), 548 received ciprofloxacin, and 624 did not. The ciprofloxacin group reported a 0% incidence of endophthalmitis compared to 0.8% in the non ciprofloxacin group. While the chi-square test revealed significant differences (p=0.036), Fisher’s exact test did not reach significance at values less than <0.05. The efficacy of oral ciprofloxacin in preventing endophthalmitis was 100%. The odds ratios for sex, age, and unilateral/bilateral surgery were not significant. Challenges in achieving statistical significance, attributable to zero events in the ciprofloxacin group, were acknowledged. Conclusion: Oral administration of two 750 mg tablets of ciprofloxacin per day for one week after phacoemulsification surgery is superior to a single intracameral antibiotic injection as an additional treatment. Health sciences/Medical research/Outcomes research Health sciences/Health care/Therapeutics/Adverse effects Endophthalmitis Extended Prophylaxis Oral Ciprofloxacin Phacoemulsification Figures Figure 1 Full Text Additional Declarations The authors declare no competing interests. Supplementary Files highlights.docx Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4232760","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":295619395,"identity":"d5594700-c6f5-4d23-bf2e-60db20f6df5a","order_by":0,"name":"Suleyman Ciftci","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA60lEQVRIie3PsQqCQBzH8f/xh3OxXC+iojc4CaKh6FWUwKmhsSkMwZai1abewlYjaOoNHBKCZl3CoaG71kpra7jvdMh9Tn4AKtU/hiQB4Kw5PF+Ozw9UKyVousB7HYgcB8ASBMt/IwhMbTcad58EyoixQC3JJ8yeu6dbkuVhq4pA0mz8mbADkvmSs45HVjszsGLTR8DaJvxMOBp7T8xv+FgJ67oVE0GoOBcRJJKQJdWvkgy/Ju1A16kkdimRWzZyC2e0WwuceOSLNwq3GOsDpPl91uQMryztx4PtwtunWQF5F3F/u69SqVSqlx6yg0XLcTuaOAAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0003-4378-2164","institution":"Diyarbakır Gazi Yasargil Training and Research Hospital","correspondingAuthor":true,"prefix":"","firstName":"Suleyman","middleName":"","lastName":"Ciftci","suffix":""}],"badges":[],"createdAt":"2024-04-07 20:50:36","currentVersionCode":2,"declarations":{"humanSubjects":false,"vertebrateSubjects":false,"conflictsOfInterestStatement":false,"humanSubjectEthicalGuidelines":false,"humanSubjectConsent":false,"humanSubjectClinicalTrial":false,"humanSubjectCaseReport":false,"vertebrateSubjectEthicalGuidelines":false},"doi":"10.21203/rs.3.rs-4232760/v2","doiUrl":"https://doi.org/10.21203/rs.3.rs-4232760/v2","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":55407782,"identity":"90386388-35b1-4528-b662-512846842fc5","added_by":"auto","created_at":"2024-04-26 22:04:09","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":1809431,"visible":true,"origin":"","legend":"\u003cp\u003eThe chi-square automatic interaction detector (CHAID) decision tree represents a machine learning algorithm that employs the chi-square test to evaluate the significance of independent categorical variables (cipro usage, sex, unilateral or bilateral surgery) in the study. In each column, the algorithm utilized the chi-squared test to identify the most substantial difference in the distribution of the target variable across categories. Notably, cipro usage emerged as the most substantial difference. In the 'Cipro not received' group, the second most substantial difference was unilateral or bilateral surgery. Conversely, within the 'cipro received' group, where the rate of endophthalmitis was zero, all other variables exhibited identical differences.\u003c/p\u003e","description":"","filename":"CHAIDChisquareAutomaticInteractionDetectors.jpg","url":"https://assets-eu.researchsquare.com/files/rs-4232760/v2/de06ce87e711b1e7694af67c.jpg"},{"id":55407781,"identity":"e865f399-e136-400a-98bf-35d1064a7ba7","added_by":"auto","created_at":"2024-04-26 22:04:09","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":6373,"visible":true,"origin":"","legend":"","description":"","filename":"highlights.docx","url":"https://assets-eu.researchsquare.com/files/rs-4232760/v2/5cd223b700c06f86e5494ab1.docx"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"\u003cp\u003e\u003cstrong\u003eExtended Postoperative Ciprofloxacin Prophylaxis for Post-Phacoemulsification Endophthalmitis\u003c/strong\u003e\u003c/p\u003e","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Endophthalmitis, Extended Prophylaxis, Oral Ciprofloxacin, Phacoemulsification","lastPublishedDoi":"10.21203/rs.3.rs-4232760/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4232760/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003ePurpose:\u003c/strong\u003e This study investigated the efficacy of extended oral ciprofloxacin prophylaxis in reducing the incidence of endophthalmitis after cataract surgery.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSetting\u003c/strong\u003e: Single-center study conducted at a tertiary health facility.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDesign:\u003c/strong\u003e This was a retrospective observational study.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e This study was conducted on patients who underwent uncomplicated phacoemulsification surgery. Two cohorts were analyzed: one receiving oral ciprofloxacin twice daily for one week post-surgery and another not receiving ciprofloxacin. The patients who did not receive ciprofloxacin were operated on between June 2013 and October 2019, while the others underwent surgery between June 2011 and April 2021. Endophthalmitis incidence, patient demographics, and surgical variables were assessed between the two groups. Statistical analyses included chi-square tests, Fisher’s exact tests, logistic regression, and Kaplan‒Meier estimates.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e Out of 1172 eyes (1015 patients), 548 received ciprofloxacin, and 624 did not. The ciprofloxacin group reported a 0% incidence of endophthalmitis compared to 0.8% in the non ciprofloxacin group. While the chi-square test revealed significant differences (p=0.036), Fisher’s exact test did not reach significance at values less than \u0026lt;0.05. The efficacy of oral ciprofloxacin in preventing endophthalmitis was 100%. The odds ratios for sex, age, and unilateral/bilateral surgery were not significant. Challenges in achieving statistical significance, attributable to zero events in the ciprofloxacin group, were acknowledged.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion:\u003c/strong\u003e Oral administration of two 750 mg tablets of ciprofloxacin per day for one week after phacoemulsification\u003cstrong\u003e \u003c/strong\u003esurgery is superior to a single intracameral antibiotic injection as an additional treatment.\u003c/p\u003e","manuscriptTitle":"Extended Postoperative Ciprofloxacin Prophylaxis for Post-Phacoemulsification Endophthalmitis","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2024-04-26 22:04:04","doi":"10.21203/rs.3.rs-4232760/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2024-04-26 01:56:49","doi":"10.21203/rs.3.rs-4232760/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"2a77dbdf-a8f4-4d04-a820-ab31dffed202","owner":[],"postedDate":"April 26th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":31220745,"name":"Health sciences/Medical research/Outcomes research"},{"id":31220746,"name":"Health sciences/Health care/Therapeutics/Adverse effects"}],"tags":[],"updatedAt":"2026-01-26T09:03:46+00:00","versionOfRecord":[],"versionCreatedAt":"2024-04-26 22:04:04","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v2","identity":"rs-4232760","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-4232760","identity":"rs-4232760","version":["v2"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}