THE EXPRESSION OF SERUM SOLUBLE B7-H4(SB7-H4) IN ENDOMETRIOSIS PATIENTS AND ITS CLINICAL SIGNIFICANCES

Objective To investigate the expression of serum soluble B7-H4(sB7-H4)in endometriosis patients and its clinical significances.MethodsELISA Sandwich method was applied to test the concentration of sB7-H4 in serum of 58 cases of endometriosis before and after operation,27 cases of benign ovarian tumor and 36 healthy female cases.Results The serum sB7-H4 levels were(39.45±6.21)μg/L in patients with endometriosis,(31.56±6.15)μg/L in patients with benign ovarian tumor,(30.85±5.57)μg/L in healthy controls,and(33.48±5.46μg/L)in patients with endometriosis after surgical treatment(P0.05).There was significant difference in the level of sB7-H4 in patients with endometriosis at different stages(P 0.05).Conclusion The serum soluble B7-H4(sB7-H4)is correlated with the occurrence of endometriosis and its level increases with the progress of the disease,and the detection of sB7-H4 has important significance for the auxiliary diagnosis of endometriosis.