Oocyte and zona imaging

David L. Keefe
In: Human Assisted Reproductive Technology · 2011 · pp. 199–208 · doi:10.1017/cbo9780511734755.019 · W2501834425
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Dopamine agonists inhibit angiogenesis in endometriosis models by promoting VEGFR-2 endocytosis in endothelial cells, preventing VEGF signaling.

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Abstract

Medical treatment of endometriosis is a necessary step in the management of the disease due to its high rate of recurrence and different clinical situations. Women with endometriosis present a peritoneal environment with increased angiogenic activity. Angiogenesis involves the formation of new blood vessels released by pre-existing vessels. Several antiangiogenic agents have been successfully tested in experimental models of endometriosis inhibiting new vessel formation. These compounds target specifically the endothelial cells without penetration in the tissues. Several anticancer drugs with antiangiogenic potential have been found to have a detrimental effect on reproductive function in both animal models and patients. The studies in experimental oncological models demonstrated that dopamine agonists (DA) have an antiangiogenic effect promoting the vascular endothelial growth factor receptors (VEGFR)-2 endocytosis in endothelial cells, preventing the VEGF-VEGFR-2 union and avoiding receptor phosphorylation and signal cascade.
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Human Assisted Reproductive Technology Buy print or eBook [Opens in a new window] Future Trends in Laboratory and Clinical Practice - Human Assisted Reproductive Technology - Human Assisted Reproductive Technology - Copyright page - Dedication - Contents - Contributors - Preface - Acknowledgments - Chapter 1 Use of robotics in reproductive surgery - Chapter 2 Removal of hydrosalpinges and uterine leiomyoma to improve IVF outcome - Chapter 3 Ovarian endometriomas: - Chapter 4 Impact of uterine cavity abnormalities on IVF and pretreatment cavity evaluation - Chapter 5 Sperm retrieval techniques - Chapter 6 New concepts in ovarian stimulation - Chapter 7 GnRH antagonists in ART - Chapter 8 Pharmacogenetics of ovarian stimulation in the twenty-first century - Chapter 9 Non-invasive diagnosis of endometriosis with proteomic technologies - Chapter 10 Antiangiogenic agents for endometriosis - Chapter 11 New concepts in the management of polycystic ovary syndrome - Chapter 12 Adjuvant therapy to increase implantation rates - Chapter 13 Ovarian hyperstimulation syndrome - Chapter 14 The evidence-based practice of assisted reproduction - Chapter 15 Three-dimensional in vitro ovarian follicle culture - Chapter 16 Artificial gametes - Chapter 17 Current status and future trends of the clinical practice of human oocyte in vitro maturation - Chapter 18 Oocyte and zona imaging - Chapter 19 Granulosa cells and their impact on human ART - Chapter 20 Sperm diagnosis: - Chapter 21 Embryo culture in the twenty-first century - Chapter 22 Morphometric analyses of embryos - Chapter 23 Embryo biopsy: - Chapter 24 Analysis of the embryonic transcriptome - Chapter 25 Analysis of embryo-derived factors as markers of developmental potential and viability - Chapter 26 Proteomics analysis of the endometrium and embryo. Can we improve IVF outcome? - Chapter 27 Analysis of embryo metabolism and the metabolome to identify the most viable embryo within a cohort - Chapter 28 Oocyte and embryo cryopreservation - Index Published online by Cambridge University Press: 16 May 2011 Book contents - Human Assisted Reproductive Technology - Human Assisted Reproductive Technology - Copyright page - Dedication - Contents - Contributors - Preface - Acknowledgments - Chapter 1 Use of robotics in reproductive surgery - Chapter 2 Removal of hydrosalpinges and uterine leiomyoma to improve IVF outcome - Chapter 3 Ovarian endometriomas: - Chapter 4 Impact of uterine cavity abnormalities on IVF and pretreatment cavity evaluation - Chapter 5 Sperm retrieval techniques - Chapter 6 New concepts in ovarian stimulation - Chapter 7 GnRH antagonists in ART - Chapter 8 Pharmacogenetics of ovarian stimulation in the twenty-first century - Chapter 9 Non-invasive diagnosis of endometriosis with proteomic technologies - Chapter 10 Antiangiogenic agents for endometriosis - Chapter 11 New concepts in the management of polycystic ovary syndrome - Chapter 12 Adjuvant therapy to increase implantation rates - Chapter 13 Ovarian hyperstimulation syndrome - Chapter 14 The evidence-based practice of assisted reproduction - Chapter 15 Three-dimensional in vitro ovarian follicle culture - Chapter 16 Artificial gametes - Chapter 17 Current status and future trends of the clinical practice of human oocyte in vitro maturation - Chapter 18 Oocyte and zona imaging - Chapter 19 Granulosa cells and their impact on human ART - Chapter 20 Sperm diagnosis: - Chapter 21 Embryo culture in the twenty-first century - Chapter 22 Morphometric analyses of embryos - Chapter 23 Embryo biopsy: - Chapter 24 Analysis of the embryonic transcriptome - Chapter 25 Analysis of embryo-derived factors as markers of developmental potential and viability - Chapter 26 Proteomics analysis of the endometrium and embryo. Can we improve IVF outcome? - Chapter 27 Analysis of embryo metabolism and the metabolome to identify the most viable embryo within a cohort - Chapter 28 Oocyte and embryo cryopreservation - Index Polscope imaging provides valuable information on the structure and architecture of themeiotic spindle and the zona pellucida (ZP), which helps predict fertilization, embryo development, and pregnancy. Differential interference contrast (DIC) is most efficient when imaging through glass coverslips, an impractical requirement for clinical in vitro fertilization (IVF), so most IVF laboratories employ variations of the DIC method, such as Hoffman modulation (HM). When imaging the oocyte for IVF, it is important to maintain tight temperature control, because both reduced and elevated temperature disrupts the integrity of the meiotic spindle. Spindles can be imaged non-invasively by polarized light microscopy. A quantitative polarized light microscope, the polscope, which uses circularly rather than plane polarized light, provides orientation-independent and, therefore, quantitative measurement of retardance in living specimens. Further studies are needed to determine whether spindle abnormalities predict aneuploidy as revealed by the more invasive preimplantation genetic screening (PGS). - Type - Chapter - Information - Human Assisted Reproductive TechnologyFuture Trends in Laboratory and Clinical Practice, pp. 199 - 208Publisher: Cambridge University PressPrint publication year: 2011 Accessibility compliance for the HTML of this chapter is currently unknown and may be updated in the future. To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle. Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply. Find out more about the Kindle Personal Document Service. - Oocyte and zona imaging - - Book: Human Assisted Reproductive Technology - Online publication: 16 May 2011 To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox. - Oocyte and zona imaging - - Book: Human Assisted Reproductive Technology - Online publication: 16 May 2011 To save content items to your account, please confirm that you agree to abide by our usage policies. 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