Human Adrenal Gland Charts within the Common Coordinate Framework from CT-based Imaging

Human Adrenal Gland Charts within the Common Coordinate Framework from CT-based Imaging | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Human Adrenal Gland Charts within the Common Coordinate Framework from CT-based Imaging Wei Liao, Hao Tang, Jiao Li, Yuxuan Qiao, Lei Qiao, Qiang Xu, and 23 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-9019513/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The human adrenal gland is a critical endocrine organ that regulates physiological processes and modulates diseases progressions. However, the extent to which adrenal gland morphometrics vary by age, sex, and pathological conditions remains limited due to challenges with the adrenal gland template. Based on large cohorts (total N = 37,251) of adrenal CT, we developed artificial intelligence-enabled methods to construct an adrenal gland common coordinate framework and to provide morphological and densitometric templates for voxel-wise statistical parametric mapping analysis. We delineated sex-stratified developmental trajectories of adrenal imaging metrics across 18 to 100 years. Adrenal developmental trajectories derived from CCF-based analysis, which was validated by conventional regional analysis, showed distinct sex-specific patterns: an inverted-U shape in males and a gradual age-related increase in females. We mapped topographic patterns of the adrenal gland associated with physical/physiological measures and changes in four adrenal gland-related pathological conditions. Our findings provided a quantitative spatial reference system for comparing and correlating bilateral adrenal gland data from multiple individuals and conditions, thereby facilitating novel insights into its physiology and pathophysiology. Biological sciences/Neuroscience/Peripheral nervous system Health sciences/Biomarkers/Diagnostic markers adrenal gland common coordinate framework Computer Tomography charts statistical parametric mapping Full Text Additional Declarations There is NO Competing Interest. Supplementary Files Supplementarymaterialsv13WL.docx Supporting information for Human Adrenal Gland Charts within the Common Coordinate Framework from CT-based Imaging Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-9019513","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":601504242,"identity":"140f1eb1-f8f2-4bc2-b988-f72237bf5499","order_by":0,"name":"Wei 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