The expression of VEGF, ER, PR in ectopic endometrium and eutopic endometrium of EM patients

This paper studies the expression of VEGF,ER and PR in ectopic and eutopic endometrium in patients who suffer from endometriosis. Using immunohistochemistry SP method, we examine respectively the expression of VEGF,ER and PR in ectopic and eutopic endometrium of 45 EM cases (study group), and the expression of VEGF,ER and PR in eutopic endometrium of 32 cases of[LM] uterine fibroid (control group). Image dissector shows that the corresponding density represents its expression intensity. The expression of VEGF is remarkably higher in the ectopic endometrium and eutopic endometrium of study group than the endometrium of control group (p<0.01). ER/PR are remarkably lower than the endometrium of control group. ER and PR are lower than the endometrium of control group only in the expression of ectopic endometrium while VEGF in ectopic endometrium is positively related to ER. The high VEGF and low ER/PR in ectopic and eutopic endometrium, together with the fact that VEGF and ER are positively related in ectopic endometrium, may be the cause of the pathogenesis of EM.