Aberrant Expression of lncRNA ( HOXA11-AS1) and Homeobox A ( HOXA9, HOXA10, HOXA11, and HOXA13) Genes in Infertile Women With Endometriosis

This study aimed to study the expression of homeobox (HOX)A11-ASI (HOXA11 antisense RNA) long noncoding RNA (IncRNA) and the expression of homeobox A (H0XA9, HOXAI0, HOXA11, and HOXA13) genes in the eutopic (EU) and ectopic (EC) endometria of women with peritoneal endometriosis. A total of 30 women undergoing laparoscopic surgery for peritoneal endometriosis and 15 infertile women without endometriosis were enrolled in this study. Peritoneal EC tissue samples were obtained through surgery. The EU tissues were obtained by curettage. The EC and EU IncRNA and messenger RNA (mRNA) expression levels were measured using real-time reverse transcriptase-polymerase chain reaction. The HOXA11-ASI IncRNA and H0XA9, HOXA10, HOXA11, and H0XAI3 mRNA were expressed at significantly lower levels in the EU than in the EC, that is, in women with peritoneal endometriosis (P <.05). The expression levels of HOXA10 and HOXA11 in the EU were significantly lower in women with peritoneal endometriosis compared to the control group participants (P .05). In conclusion, the study findings suggest that HOXA11-ASI IncRNA may play a role in the development of peritoneal endometriosis, but HOXA11-ASI may not influence endometrial receptivity in endometriosis-associated infertility. Similar content being viewed by others

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Aberrant Expression of IncRNA (HOXAII-ASI) and Homeobox A (HOXA9, HOXA10, HOXA11, and HOXA13) Genes in Infertile Women with Endometriosis. Reprod. Sci. 25, 654–661 (2018). https://doi.org/10.1177/1933719117734320 Published: Version of record: Issue date: DOI: https://doi.org/10.1177/1933719117734320