Study of Factors Affecting the Success of Intra Uterine Insemination in Pregnancy

Introduction: Marital sterility is one of the major concern by World Health Organization, which has declared as the disease and estimated that 15% of couples have been treated by this disease. The causes of marital infertility are 45-50% of men, 45-50% of women and 5-10% couples with unknown causes. Aim and Objectives: The basic aim of the present study was to make the assessment of successfulness of intrauterine insemination (IUI) as one of the methods of treatment of infertility. Materials and Methods: A total of 27 infertile married couples were taken for study, where 52 cycles were stimulated. In 42 (80.7%) of cycles the ovulation was confi rmed, and IUI was made by husband’s sperm, which was prepared by swim-up modifi ed method. In 10 cycles there has been no adequate growth of follicles and folliculogenesis stimulation was interrupted. The major causes of infertility in the study group were: Cause of male infertility (n = 11) mild and easy forms of endometriosis (n = 6) cervical factor (n = 4) and polycystic ovarian syndrome (PCOS) (n = 6). Results: The pregnancy occurred in four female patients. Percentage of pregnancy was 10.8%, compared with cycles in which ovulation was confi rmed, after which IUI was done. Percentage of pregnancy in married couples, according to the different causes of infertility was: Infertility caused by cervical factor of 25%, the causes of male infertility 16.6%, with mild or easy endometriosis 18.2%, PCOS 16.6%. Discussion: Examination presents prospective study, which included 27 infertile couples, in which ovarian stimulation were performed with clomiphene citrate and made IUI. In 18 pairs was about the secondary, and in 9 pairs, the primary infertility. We believe that our results are satisfactorily and consistent with published results in the reference literature. Conclusion: IUI is a cheap and minimally invasive method compared to other methods of assisted reproduction. Numerous reports indicate that the pregnancy rate is much higher if the IUI is combined with controlled ovarian stimulation.