Adenomyosis is Associated with Sub-Optimal Outcomes in Fresh Embryo Transfer Cycles

Siddhartha Nagireddy, Reddy NS, M urangi, Radha Vembu, Thilagavathy D O Muthusamy, Kanomozhi Kasinathan
In: Journal of Research in Medical and Dental Science · 2021 · vol. 9(2) , pp. 211–215 · W3133980158
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This retrospective case control study found that adenomyosis was associated with decreased pregnancy, implantation, clinical pregnancy, and live birth rates in fresh embryo transfer cycles following ICSI.

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This retrospective case-control study evaluated the impact of adenomyosis on intracytoplasmic sperm injection (ICSI) outcomes by analyzing medical records from 89 women undergoing fresh embryo transfers. The research specifically compared clinical pregnancy, implantation, and live birth rates between patients diagnosed with adenomyosis via transvaginal sonography and those without the condition. The authors concluded that adenomyosis is significantly associated with decreased pregnancy, implantation, and live birth rates in these assisted reproductive technology cycles. This paper is centrally about adenomyosis — specifically its negative correlation with successful fresh embryo transfer outcomes in ICSI cycles.

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Abstract

Context: Adenomyosis is known to affect the outcome of ART by reduced clinical pregnancies and increased miscarriage rates. Several mechanisms were proposed as causative factors such as increased myometrial contractions, decreased implantation and altered endometrial receptivity. But the conclusions from previous studies were mutually conflicting. Aims: to study the effect of adenomyosis on the outcome of ICSI cycles. Objectives: Primary: To study the effect of adenomyosis on pregnancy rate in ICSI fresh embryo transfer cycles. Secondary: To study the effect of adenomyosis on implantation, clinical pregnancy and miscarriage rates in ICSI fresh embryo transfer cycles. Settings and Design: Retrospective case control study. Performed at a tertiary care university teaching hospital. Methods and Material: The data of 89 women, who underwent ICSI and fresh transfer from Jan 2002 to March 2019 and satisfied the study criteria, was obtained from the hospital medical records department. Of them 47 women who were diagnosed to have adenomyosis by transvaginal sonography were included in the study. Statistical analysis used: SPSS version 17 software was used and P<0.05 was considered statistically significant. Results: The pregnancy, clinical pregnancy, implantation rates and live birth rates were 25.7, 23.4, 7.6% and 17%, respectively. Conclusions: Adenomyosis is associated with decreased pregnancy, implantation and live births in ICSI cycles.
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Abstract

Context: Adenomyosis is known to affect the outcome of ART by reduced clinical pregnancies and increased miscarriage rates. Several mechanisms were proposed as causative factors such as increased myometrial contractions, decreased implantation and altered endometrial receptivity. But the conclusions from previous studies were mutually conflicting. Aims: to study the effect of adenomyosis on the outcome of ICSI cycles.

Objectives

Primary: To study the effect of adenomyosis on pregnancy rate in ICSI fresh embryo transfer cycles. Secondary: To study the effect of adenomyosis on implantation, clinical pregnancy and miscarriage rates in ICSI fresh embryo transfer cycles. Settings and Design: Retrospective case control study. Performed at a tertiary care university teaching hospital.

Methods

and Material: The data of 89 women, who underwent ICSI and fresh transfer from Jan 2002 to March 2019 and satisfied the study criteria, was obtained from the hospital medical records department. Of them 47 women who were diagnosed to have adenomyosis by transvaginal sonography were included in the study. Statistical analysis used: SPSS version 17 software was used and P<0.05 was considered statistically significant.

Results

The pregnancy, clinical pregnancy, implantation rates and live birth rates were 25.7, 23.4, 7.6% and 17%, respectively.

Conclusions

Adenomyosis is associated with decreased pregnancy, implantation and live births in ICSI cycles.

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