Two Cases of Hyperadrenocorticism in Ferrets

Because of high serum levels of 17α-hydroxyprogesterone, two ferrets with bilateral symmetrical alopecia of the trunk were tentatively diagnosed as having hyperadrenocorticism. Abdominal computed tomography revealed no obvious adrenal enlargement in either animal. In case 1, treatment with danazol followed by cyproterone acetate produced no fur recovery. Histopathological examinations revealed adrenocortical carcinoma in both animals. In about a month and a half after tumid left adrenal resection, both ferrets' fur had completely recovered. The animals continue in good condition at the present. In case 1, serum 17 α-hydroxyprogesterone has dropped to the normal range.