Assessment of Lipid Profile in Females Suffering from Endometriosis

Mehwish Iftikhar, Bushra Iftikhar, Mahwish Shahzad, Junaid Iqbal, Aliya Aslam, Mirza Ameer Faizan Ali
In: Proceedings · 2022 · vol. 36(2) , pp. 23–28 · doi:10.47489/pszmc-836362-23-28 · W4282822725
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This study found significantly elevated total cholesterol, triglycerides, and LDL, with reduced HDL, in females with endometriosis compared to healthy controls.

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This cross-sectional analytical study over six months in Lahore measured serum lipid profiles in 30 young women with endometriosis and 30 healthy controls, analyzing total cholesterol, triglycerides, LDL, and HDL from venous blood samples. The authors found significantly higher total cholesterol, triglycerides, and LDL in the endometriosis group, alongside reduced HDL levels compared with controls. The study’s main limitation is the small sample size and its cross-sectional design, which assesses lipid differences at one time point rather than establishing causality. This paper is centrally about endometriosis — it evaluates dyslipidemia (TC, TG, LDL, HDL) in women with endometriosis and reports significant lipid profile differences versus controls.

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Abstract

Introduction: Endometriosis is a prevalent, multifactorial benign gynaecological disorder, characterized by the formation of endometrial and stromal tissue outside the lining of the uterus. 10-15% women suffer from endometriosis at the age between 20-35 years. Exact etiology of endometriosis is not clear but serum lipid level may play important role to cause endometriosis. Aims & Objectives: The current study aims to determine the prevalence of dyslipidemias in young women suffering from endometriosis. Hyperlipidemias implicate inflammation and oxidative stress which may play an important role in the aetiology of endometriosis. Place and duration of study: A cross sectional analytical research of six months duration was conducted in Chaudhry Muhammad Akram Teaching and Research Hospital, Lahore. Material & Methods:Lipid profile such asTotal cholesterol, Triglycerides, Low density lipoprotein (LDL) and high- density lipoprotein were biochemically analyzed from venous blood of 30 females with endometriosis and 30 healthy controls by kit method. Results:Result of present study demonstrated significant (p=0.025, <0.001 and 0.036) elevated levels oftotal cholesterol (TC), triglycerides (TG) and low-density lipoprotein (LDL) respectively in patients than that of control ones. Whereas the level of High-density lipoprotein (HDL) was reduced (23.53±4.76 mg/dl) in females with endometriosis as compared to healthy individuals (65.20±8.78 mg/dl). Conclusion: In present study, raised lipid profile in females with endometriosis demonstrated substantial etiological role of lipids in the pathogenicity of endometriosis.
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Introduction

Endometriosis is a prevalent, multifactorial benign gynaecological disorder, characterized by the formation of endometrial and stromal tissue outside the lining of the uterus. 10-15% women suffer from endometriosis at the age between 20-35 years. Exact etiology of endometriosis is not clear but serum lipid level may play important role to cause endometriosis. Aims & Objectives: The current study aims to determine the prevalence of dyslipidemias in young women suffering from endometriosis. Hyperlipidemias implicate inflammation and oxidative stress which may play an important role in the aetiology of endometriosis. Place and duration of study: A cross sectional analytical research of six months duration was conducted in Chaudhry Muhammad Akram Teaching and Research Hospital, Lahore.

Material

& Methods:Lipid profile such asTotal cholesterol, Triglycerides, Low density lipoprotein (LDL) and high- density lipoprotein were biochemically analyzed from venous blood of 30 females with endometriosis and 30 healthy controls by kit method. Results:Result of present study demonstrated significant (p=0.025, <0.001 and 0.036) elevated levels oftotal cholesterol (TC), triglycerides (TG) and low-density lipoprotein (LDL) respectively in patients than that of control ones. Whereas the level of High-density lipoprotein (HDL) was reduced (23.53±4.76 mg/dl) in females with endometriosis as compared to healthy individuals (65.20±8.78 mg/dl).

Conclusion

In present study, raised lipid profile in females with endometriosis demonstrated substantial etiological role of lipids in the pathogenicity of endometriosis.

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