EXPRESSION OF PTEN GENE IN ENDOMETRIOSIS OF THE OVARY
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This study found significantly different PTEN mRNA expression in ovarian endometriosis tissues compared to normal ovaries, with expression levels correlating with disease staging but not patient age or cyst size.
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Abstract
Objective To investigate the expression of PTEN gene in endometriosis of the ovary and its clinical significance. Methods The expression of PTEN mRNA was detected by semi-quantitative reverse transcription polymerase chain reaction(RT-PCR)in tissues of endometriosis and normal ovary. Results The difference between the relative expression level of PTEN mRNA exon 1-9 and 5-9 in tissues of endometriosis and normal ovary was statistically significant (t=3.122, 2.209,P 0.01 ,0.05). The expression level of PTEN mRNA in endometriosis of ovary was related to staging (t=2.678,2.284,P0.01, 0.05 ), but not to ages of the patients and sizes of cysts (t=0.111-1.447,P0.05). Conclusion PTEN gene inactivation may represent early events in the transformation of benign endometriotic cells to malignancy.
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- last seen: 2026-06-10T17:14:06.276822+00:00
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