Effects of PKF 115–584 on Cyclin D1 expression.

A, B: Cyclin D1 mRNA expression in non-treated epithelial (A) and stromal (B) cells of endometriotic tissue and matched eutopic endometrium of the same patients. C, D: Cyclin D1 mRNA expression in PKF 115–584–treated epithelial (C) and stromal (D) cells of endometriotic tissue and matched eutopic endometrium of the same patients. Numerical values are presented as the mean+SEM. Expression levels of Cyclin D1 mRNA are given relative to the expression levels of the reference gene, GAPDH. P: proliferative phase, S: secretory phase. DE: deep infiltrating endometriosis (epithelial cells: P: n = 6, S: n = 6, stromal cells: P: n = 6, S: n = 6). OE: ovarian endometriosis (epithelial cells: P: n = 6, S: n = 6; stromal cells: P: n = 6, S: n = 6). SE: superficial peritoneal endometriosis (epithelial cells: P: n = 4, S: n = 4; stromal cells: P: n = 4, S: n = 4). a: p<.05 versus matched eutopic endometrium of the same patients.