The acute effect of atropine 0.1% on the axial length and choroid of children treated for myopia progression prevention, measured by optical coherence tomography angiography

The acute effect of atropine 0.1% on the axial length and choroid of children treated for myopia progression prevention, measured by optical coherence tomography angiography | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The acute effect of atropine 0.1% on the axial length and choroid of children treated for myopia progression prevention, measured by optical coherence tomography angiography Jannis Koulalis, Pieter Nelis, Wilfried Cools, Fatma Tezcan, Robert W. Kuijpers This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3911852/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purpose The purpose of this study was to investigate the acute effect of atropine to better understand atropine’s mechanism of action in myopia prevention. The present study investigates whether atropine’s effect on the AxL comes forth from an increase in choroidal thickness (ChT) using SS-OCTa (swept source optical coherence tomography angiography). Methods Twenty-five myopic children (25 eyes) (9 male and 16 females; mean age 11.8 years, range 7-15 years) were enrolled following documented myopia progression and AxL increase in the preceding 6 months. Using SS-OCTa, ChT and CSV (choroidal stromal volume) were measured at baseline and after 1 month of daily Atropine 0.1% use. AxL measurements were taken on the same days. Results Following one month of daily instillation with atropine 0.1%, ChT increased by 22.41 ± 4.20 μm (p < 0,01), CSV increased by 1.08 ± 1.02 mm3 (p < 0,01) and AxL decreased by 0.044 ± 0.016 mm (p < 0,05), shown by mean ± standard error (SE). The CSV and ChT increase show a negative correlation with the AxL decrease of -0.462 and -0.374 respectively, demonstrating a weak to moderate correlation. Conclusions Administration of atropine 0.1% eye drops daily over one month demonstrated an acute decrease in AxL concurrent with an increase in ChT and CSV. A direct cause-and-effect relationship between these two parameters is plausible, supporting a differentiated effect in the immediate and long-term effects of atropine eye drops. myopia atropine choroid OCT angiography Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3911852","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":270242638,"identity":"0d2d4b96-1b41-4885-b47a-3a1576abbeeb","order_by":0,"name":"Jannis Koulalis","email":"","orcid":"","institution":"Vrije Universiteit Brussel, University Hospital UZ Brussel","correspondingAuthor":false,"prefix":"","firstName":"Jannis","middleName":"","lastName":"Koulalis","suffix":""},{"id":270242639,"identity":"6e5b748f-39e7-4a16-89b7-ce82698ca7c8","order_by":1,"name":"Pieter Nelis","email":"","orcid":"","institution":"ZNA Cadix","correspondingAuthor":false,"prefix":"","firstName":"Pieter","middleName":"","lastName":"Nelis","suffix":""},{"id":270242640,"identity":"d9ef5448-2e86-4f61-8cb3-cee64ee662f2","order_by":2,"name":"Wilfried Cools","email":"","orcid":"","institution":"Vrije Universiteit Brussel","correspondingAuthor":false,"prefix":"","firstName":"Wilfried","middleName":"","lastName":"Cools","suffix":""},{"id":270242641,"identity":"3be65f8c-6253-4a03-8fe7-9be22c5274b7","order_by":3,"name":"Fatma Tezcan","email":"","orcid":"","institution":"Vrije Universiteit Brussel, University Hospital UZ Brussel","correspondingAuthor":false,"prefix":"","firstName":"Fatma","middleName":"","lastName":"Tezcan","suffix":""},{"id":270242643,"identity":"12178f96-424d-467e-a416-24ae94fea278","order_by":4,"name":"Robert W. Kuijpers","email":"data:image/png;base64,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","orcid":"","institution":"Vrije Universiteit Brussel, University Hospital UZ Brussel","correspondingAuthor":true,"prefix":"","firstName":"Robert","middleName":"W.","lastName":"Kuijpers","suffix":""}],"badges":[],"createdAt":"2024-01-30 21:59:03","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3911852/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3911852/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":58400971,"identity":"690eb4ec-3da6-45bd-913e-41a33fad75ac","added_by":"auto","created_at":"2024-06-15 04:31:18","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":435683,"visible":true,"origin":"","legend":"","description":"","filename":"Theacuteeffectofatropine0.1ontheaxiallengthandchoroidofchildrentreatedformyopiaprogressionpreventionmeasuredbyopticalcoherencetomographyangiography..pdf","url":"https://assets-eu.researchsquare.com/files/rs-3911852/v1_covered_d2f9ecd8-3120-4285-898e-c145b72ece4e.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"The acute effect of atropine 0.1% on the axial length and choroid of children treated for myopia progression prevention, measured by optical coherence tomography angiography","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"myopia, atropine, choroid, OCT angiography","lastPublishedDoi":"10.21203/rs.3.rs-3911852/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3911852/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003ePurpose The purpose of this study was to investigate the acute effect of atropine to better understand atropine’s mechanism of action in myopia prevention. The present study investigates whether atropine’s effect on the AxL comes forth from an increase in choroidal thickness (ChT) using SS-OCTa (swept source optical coherence tomography angiography).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eMethods Twenty-five myopic children (25 eyes) (9 male and 16 females; mean age 11.8 years, range 7-15 years) were enrolled following documented myopia progression and AxL increase in the preceding 6 months. Using SS-OCTa, ChT and CSV (choroidal stromal volume) were measured at baseline and after 1 month of daily Atropine 0.1% use. AxL measurements were taken on the same days.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eResults Following one month of daily instillation with atropine 0.1%, ChT increased by 22.41 ± 4.20\u0026nbsp;μm (p \u0026lt; 0,01), CSV increased by 1.08 ± 1.02\u0026nbsp;mm3 (p \u0026lt; 0,01) and AxL decreased by 0.044 ± 0.016 mm (p \u0026lt; 0,05), shown by mean ± standard error (SE). The CSV and ChT increase show a negative correlation with the AxL decrease of -0.462 and -0.374 respectively, demonstrating a weak to moderate correlation. \u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eConclusions Administration of atropine 0.1% eye drops daily over one month demonstrated an acute decrease in AxL concurrent with an increase in ChT and CSV. A direct cause-and-effect relationship between these two parameters is plausible, supporting a differentiated effect in the immediate and long-term effects of atropine eye drops.\u003c/p\u003e","manuscriptTitle":"The acute effect of atropine 0.1% on the axial length and choroid of children treated for myopia progression prevention, measured by optical coherence tomography angiography","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-02-02 18:10:08","doi":"10.21203/rs.3.rs-3911852/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"dc8b1833-599a-4365-ad98-68ca99563f88","owner":[],"postedDate":"February 2nd, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-06-15T04:23:11+00:00","versionOfRecord":[],"versionCreatedAt":"2024-02-02 18:10:08","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3911852","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3911852","identity":"rs-3911852","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}