[Clinico-morphological features of endometrioid disease: adenomyosis, ovarian endometriosis, extragenital endometriosis].

Adenomyosis, ovarian endometriosis and extragenital endometriosis are clinico-pathologic types of one nosologic form as endometrioid disease (ED). ED's clinical presentations are various, but they are essentially characterized by a pain syndrome and disorder of menstrual cycle. The comparative clinico-pathologic analysis of adenomyosis, ovarian endometriosis, and extragenital endometriosis affords to suppose that theirs clinical course, the intensity and character of symptoms, as well as morphogenetic processes are generally determined by the organ localization. Topography of foci, theirs organ localization, morphological and morphofunctional features vary within one type of ED and even within one organ. So the separation of various ED's morphofunctional forms, its clinico-phatological features and intensity of its morphofunctional activity is necessary. All forms of ED have general morphogenesis features including the various form of proliferation, secretion, regression, wave-like courses of dishormonal morphogenetic manifestation within one organ. Typical for all ED's types pathologic synthesis of aromatase cytochrome P-450 promotes the local estrogens synthesis from androgens, transition of endometrioid heterotopias to the quite different level of existence and self-regulation contributing autonomous wave-like chronic ED' clinic course.