Effect of Mifepristone on OPN and MMP-9 in Endometriosis Models of Rats

Objective To explore the expression features of OPN and MMP-9 in different tissues and the effect of mifepristone on the endometriosis models in rats Methods Of 13EMS model rats,6 rats were randomly selected as the control group(N group),while the other 7 rats were gived mifepristone(Mife group).Expression of OPN and MMP-9 in eutopic and ectopic tissue were detected at 28th day after administration by RT-PCR and ICH.Results Expression of OPN and MMP-9 in tissue of Mife group were significantly lower(P0.05)than than of N group.Expression of OPN in ectopic endometria in N group were significantly higher than that of normal tissue.Compared with eutopic endometria,expression of MMP-9 were significantly higher in ectopic tissue in both groups after intervention.Expression of OPN mRNA were significantly lower in ectopic tissue in N group after intervention than that in N group no intervention.Conclusion Mifepristone may lower expression of OPN and MMP-9 in eutopic and ectopic endometria from endometriosis models in rats.Compared with eutopic tissue,effect of mifepristone on OPN were significant in ectopic tissue.The effec of mifepristone on MMP-9 in eutopic tissue may stronger than that in ectopic tissue.Mifepristone maybe suppress expression of OPN and MMP-9 to reduce the adhesion and attack ability of endometria.