0810 Objective and Subjective Sleep Characteristics in Women with Endometriosis: A Pilot Study

Abstract Introduction Endometriosis is a chronic gynecological disorder that affects 10% of women of reproductive age, associated with pain, fatigue, and diminished quality of life. Over 70% of women with endometriosis experience significant sleep difficulties, such as poor sleep quality, insomnia, and daytime sleepiness. Despite the high prevalence of these sleep difficulties, few studies have examined both objective (e.g., actigraphy) and subjective (e.g., sleep diaries) sleep parameters prospectively in this population. Methods Nine women 32.5 (7.0) years old were recruited as part of a pilot study assessing the feasibility and acceptability of mindfulness-based intervention for endometriosis surgery. All participants had a probable or confirmed diagnosis of endometriosis, making them candidates for surgery. Participants wore an actigraphy device (wGt3X-BT) and completed consensus sleep diaries for at least 14 consecutive days. We examined bedtime, waketime, sleep midpoint, sleep onset latency (SOL), number of awakenings, wake after sleep onset (WASO), total sleep time (TST), time in bed (TIB), and sleep efficiency (SE) in the 7 days prior to surgery. Results Actigraphy demonstrated an average bedtime at 21:22, rising time at 7:06, and sleep midpoint at 1:33, with normative SOL (13.3±19.8 minutes) and TST (7.9±1.3 hours), yet increased awakenings (21.3±10.5), WASO (96.0±55.8 minutes) and TIB (9.7±1.4 hours), and decreased SE (81.5±8.7). Sleep diary was commensurate with bedtime (21:28), rising time (7:02), and TIB (9.6±1.6) actigraphy estimates, yet showed longer SOL (28.2±21.9), later sleep midpoint (2:03), less awakenings (3.5±3.1), longer WASO (70.6±77.1), shorter TST (7.0±1.5), and lower SE (61.5±29.9). Sleep diary captured that 9.1% of the days had at least one nap and 33.4% of the nights were rated as “poor” and 40.7% as “fair” sleep quality. Sleep medication use was minimal (1.8%). Conclusion Women with endometriosis demonstrated a high burden of disturbed sleep captured by both objective and subjective measures, underscoring sleep as a clinically relevant but often underrecognized component of the disease. Objective sleep alterations only partially overlapped with sleep self-reports, suggesting that both methods are essential in understanding sleep disruption in this population. These findings support the value of integrating multimodal sleep assessments into endometriosis research and care. Support (if any) Penn State