Left Subclavian Pseudoaneurysm Secondary to Cervical Biopsy: A Novel Case Report | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Left Subclavian Pseudoaneurysm Secondary to Cervical Biopsy: A Novel Case Report Snehasis Das, Karthik Kanna Venkatesh This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6419925/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Iatrogenic vascular injuries, though infrequent, pose significant morbidity risks, particularly in anatomically complex regions such as the cervical and subclavian territories. We present a case of 35 years old female with chronic kidney disease (CKD), and hypertension (HTN), and a history of thyroidectomy who developed a left subclavian pseudoaneurysm following a cervical biopsy. This case underscores the necessity for heightened vigilance and meticulous procedural execution in cervical interventions to prevent catastrophic vascular sequelae Surgery Subclavian pseudoaneurysm Cervical biopsy complication iatrogenic vascular injury hypertension chronic kidney disease vascular surgery endovascular repair Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Introduction Pseudoaneurysms, or false aneurysms, arise secondary to arterial wall disruption, leading to extraluminal hematoma formation encapsulated by fibrous tissue [ 1 ]. The subclavian artery, given its proximity to the cervical region, is particularly vulnerable to iatrogenic insult during invasive procedures [ 2 ]. While cervical biopsies are generally considered safe inadvertent arterial trauma may precipitate pseudoaneurysm formation, manifesting as progressive swelling, pulsatile masses, or compressive symptoms. After an extensive literature review, this case appears to be the first documented instance of a biopsy-induced subclavian pseudoaneurysm, establishing a novel precedent in vascular pathology. Case Report Presentation and Initial Workup In May 2022, a 35-year-old female presented to the general surgery emergency department with a one-year history of persistent, progressive left supraclavicular swelling (Fig. 1). Over the preceding month, the swelling had increased in size significantly, accompanied by pain, palpitations, hoarseness of voice, and weight loss. The insidious onset and progressive nature of the swelling raised clinical suspicion for an underlying vascular event, particularly following a recent cervical lymph node biopsy performed for suspected infectious etiology. On examination, the swelling was pulsatile, tender, and prominent in the supraclavicular region, strongly indicative of a vascular abnormality. Her blood pressure at presentation was 170/102 mmHg. The patient had a history of hypertension, hyperthyroidism, CKD, and coronary artery disease (CAD), for which she was on regular medications. She had no history of smoking or alcohol consumption. Diagnostic Imaging A contrast-enhanced computed tomography angiography (CTA) of the neck, thorax, and abdomen with three-dimensional reconstruction delineated a 6.5 × 6.5 × 8 cm pseudoaneurysm of the left subclavian artery (Fig. 2, Fig. 3, Fig. 4). The morphology, along with the temporal correlation to the biopsy, suggested an iatrogenic vascular injury as the underlying cause. Incidentally, CTA also revealed multiple aneurysmal dilations involving the abdominal aorta, bilateral common iliac arteries, left coronary artery, and right renal artery. Suspected infected pathology raised suspicion for disseminated infection-associated mycotic aneurysms rather than a generalized vasculopathic process. The constellation of findings necessitated further systemic evaluation. Management and Outcomes Surgical Intervention for Subclavian Pseudoaneurysm Given the progressive enlargement of the pseudoaneurysm and its high risk of rupture, a multidisciplinary approach involving vascular surgery and cardiothoracic surgery was undertaken. Urgent neck exploration with medial sternotomy was performed, followed by subclavian artery resection and vascular reconstruction using an interposition graft. The intraoperative period was uneventful, with meticulous hemostasis and no significant blood loss. Postoperatively, the patient demonstrated hemodynamic stability and complete resolution of symptoms, with no recurrence of swelling or neurovascular compromise. She was subsequently discharged with antihypertensive optimization and scheduled for regular vascular follow-up (Fig. 5). Management of Incidentally Discovered Aneurysms A structured plan was formulated for the incidentally detected aneurysms, with conservative monitoring for the abdominal aorta and iliac aneurysms, percutaneous intervention for the coronary artery aneurysm, and endovascular embolization for the renal artery aneurysm. Additionally, a systemic infectious workup was initiated to evaluate for an underlying disseminated etiology. Discussions The subclavian artery, due to its deep anatomical positioning and proximity to the scalene musculature and clavicle, is rarely affected by external trauma or iatrogenic injury [ 2 ]. However, invasive procedures such as central venous catheter placement have been associated with iatrogenic arterial trauma [ 2 ]. The development of a subclavian pseudoaneurysm following a cervical lymph node biopsy has not been previously reported, making this a unique and significant addition to the medical literature. The clinical presentation of subclavian pseudoaneurysms varies depending on size and location, but a tender, pulsatile mass remains a common feature [ 3 ]. Due to the subclavian artery’s proximity to vital neurovascular structures, complications can include chest and shoulder pain, dysphagia, hoarseness, venous congestion, and Horner’s syndrome, all of which were observed in this patient [ 2 ]. In more severe cases, limb ischemia and cerebrovascular events have been reported, making timely diagnosis and intervention imperative [ 3 ]. While iatrogenic pseudoaneurysms are rare following cervical interventions, their potential for catastrophic complications necessitates a high index of suspicion, particularly in high-risk patients with predisposing vascular pathologies such as HTN, CKD, and CAD. The delayed presentation in this case further emphasizes the need for extended postprocedural surveillance in susceptible individuals. Endovascular stenting and ultrasound-guided thrombin injection are emerging minimally invasive alternatives to traditional open surgical repair [ 4 ]. However, surgical excision remains the gold standard in cases with mass effect or impending rupture [ 4 ]. In this patient, the decision for open surgical reconstruction was dictated by the size, location, and hemodynamic impact of the pseudoaneurysm. Additionally, postoperative surveillance for endoleak remains critical, as secondary intervention may be required [ 4 ]. Better results can be achieved by emergent management to prevent complications such as rupture or gangrene arising due to thrombosis or embolism [ 5 , 6 ]. Given the presence of multiple aneurysms, the possibility of a disseminated infectious etiology such as mycotic aneurysms was strongly considered, reinforcing the need for systemic evaluation and long-term follow-up [ 2 ]. Conclusion This case underscores the importance of meticulous procedural technique and vigilant postprocedural surveillance in cervical interventions. Clinicians must maintain a high index of suspicion for pseudoaneurysm formation in patients presenting with postprocedural swelling, particularly in complex anatomical regions such as the subclavian artery. Prompt CTA evaluation remains the cornerstone for early diagnosis and management, ultimately preventing life-threatening complications. To the best of our knowledge, this is the first documented case of a biopsy-induced subclavian pseudoaneurysm, emphasizing the need for heightened awareness and refined surgical strategies in similar clinical scenarios. Declarations Statement on Participant Consent: The patient gave consent to publish their case Disclaimers: All images and case details are available with the authors of this case report Sources of support: There was no source of support Number of tables and figures: 5 images (2 CTA, 1 3D reconstruction image, 1 image, 1 chest radiography) Conflict of Interest: No authors have any conflict of interest regarding this case report Patient Consent: The authors of this article have received and archived written patient consent References Mašković J, Radonić V, Janković S, Cambj-Sapunar L, Mimica Ž, Bačić A (2001) Traumatic false aneurysm of the subclavian artery treated by insertion of Memotherm stent. Eur J Radiol 38(3):205–208 Subclavian Artery Pseudoaneurysm Following Bedside Temporary Hemodialysis Catheter Insertion A Case Report [Internet]. [cited 2025 Feb 11]. Available from: https://www.mdpi.com/1648-9144/59/11/2038 Francis D, Kumar M, Singh M, Okafor TL, Reddy MMRK, Inban P et al (2023) Endovascular management of traumatic pseudoaneurysm of left subclavian artery: A case report. Radiol Case Rep 18(11):4066–4070 Jaiswal LS, Prasad JN, Maharjan R, Pandit N (2018) Giant pseudoaneurysm of subclavian artery after blunt chest trauma. J Vasc Surg Cases Innov Tech 4(3):220–222 Almadwahi N, Halboob E (2022) Open Surgical Repair of Traumatic Subclavian Artery Pseudoaneurysm: A Case Report. Int Med Case Rep J 15:671–675 Jaiswal D (2022) Management of Subclavian Artery Pseudoaneurysm. Case Ser. ;5(1) Additional Declarations The authors declare no competing interests. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6419925","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":441152502,"identity":"290dd6ba-f83f-42dd-b842-f15dd48ec448","order_by":0,"name":"Snehasis 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3","display":"","copyAsset":false,"role":"figure","size":153139,"visible":true,"origin":"","legend":"\u003cp\u003eTitle of image 3: Contrast Enhanced Tomography Angiography- Coronal section (Yellow arrow- Supraclavicular mass)\u003c/p\u003e","description":"","filename":"Subclavianpseudoaneurysmfigure3.png","url":"https://assets-eu.researchsquare.com/files/rs-6419925/v1/eb19ff04f512ebaa1aa63704.png"},{"id":80725945,"identity":"4afc4b4a-3868-49aa-a147-cc88f146bcf5","added_by":"auto","created_at":"2025-04-16 11:45:42","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":928640,"visible":true,"origin":"","legend":"\u003cp\u003eTitle of image 4: 3D reconstruction image of Contrast Enhanced Tomography Angiography (Yellow arrow- Pseudoaneurysm of the left subclavian 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11:53:53","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1552845,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6419925/v1/84482e6f-3f20-4bf0-8ae2-2e8e77c2ef47.pdf"}],"financialInterests":"The authors declare no competing interests.","formattedTitle":"\u003cp\u003eLeft Subclavian Pseudoaneurysm Secondary to Cervical Biopsy: A Novel Case Report\u003c/p\u003e","fulltext":[{"header":"Introduction","content":"\u003cp\u003ePseudoaneurysms, or false aneurysms, arise secondary to arterial wall disruption, leading to extraluminal hematoma formation encapsulated by fibrous tissue [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. The subclavian artery, given its proximity to the cervical region, is particularly vulnerable to iatrogenic insult during invasive procedures [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. While cervical biopsies are generally considered safe inadvertent arterial trauma may precipitate pseudoaneurysm formation, manifesting as progressive swelling, pulsatile masses, or compressive symptoms. After an extensive literature review, this case appears to be the first documented instance of a biopsy-induced subclavian pseudoaneurysm, establishing a novel precedent in vascular pathology.\u003c/p\u003e "},{"header":"Case Report","content":"\u003cp\u003ePresentation and Initial Workup\u003c/p\u003e\u003cp\u003eIn May 2022, a 35-year-old female presented to the general surgery emergency department with a one-year history of persistent, progressive left supraclavicular swelling (Fig.\u0026nbsp;1). Over the preceding month, the swelling had increased in size significantly, accompanied by pain, palpitations, hoarseness of voice, and weight loss. The insidious onset and progressive nature of the swelling raised clinical suspicion for an underlying vascular event, particularly following a recent cervical lymph node biopsy performed for suspected infectious etiology.\u003c/p\u003e\u003cp\u003eOn examination, the swelling was pulsatile, tender, and prominent in the supraclavicular region, strongly indicative of a vascular abnormality. Her blood pressure at presentation was 170/102 mmHg. The patient had a history of hypertension, hyperthyroidism, CKD, and coronary artery disease (CAD), for which she was on regular medications. She had no history of smoking or alcohol consumption.\u003c/p\u003e\u003cp\u003eDiagnostic Imaging\u003c/p\u003e\u003cp\u003eA contrast-enhanced computed tomography angiography (CTA) of the neck, thorax, and abdomen with three-dimensional reconstruction delineated a 6.5 × 6.5 × 8 cm pseudoaneurysm of the left subclavian artery (Fig.\u0026nbsp;2, Fig.\u0026nbsp;3, Fig.\u0026nbsp;4). The morphology, along with the temporal correlation to the biopsy, suggested an iatrogenic vascular injury as the underlying cause.\u003c/p\u003e\u003cp\u003eIncidentally, CTA also revealed multiple aneurysmal dilations involving the abdominal aorta, bilateral common iliac arteries, left coronary artery, and right renal artery. Suspected infected pathology raised suspicion for disseminated infection-associated mycotic aneurysms rather than a generalized vasculopathic process. The constellation of findings necessitated further systemic evaluation.\u003c/p\u003e\u003cp\u003eManagement and Outcomes\u003c/p\u003e\u003cp\u003eSurgical Intervention for Subclavian Pseudoaneurysm\u003c/p\u003e\u003cp\u003eGiven the progressive enlargement of the pseudoaneurysm and its high risk of rupture, a multidisciplinary approach involving vascular surgery and cardiothoracic surgery was undertaken. Urgent neck exploration with medial sternotomy was performed, followed by subclavian artery resection and vascular reconstruction using an interposition graft. The intraoperative period was uneventful, with meticulous hemostasis and no significant blood loss.\u003c/p\u003e\u003cp\u003ePostoperatively, the patient demonstrated hemodynamic stability and complete resolution of symptoms, with no recurrence of swelling or neurovascular compromise. She was subsequently discharged with antihypertensive optimization and scheduled for regular vascular follow-up (Fig.\u0026nbsp;5).\u003c/p\u003e\u003cp\u003eManagement of Incidentally Discovered Aneurysms\u003c/p\u003e\u003cp\u003eA structured plan was formulated for the incidentally detected aneurysms, with conservative monitoring for the abdominal aorta and iliac aneurysms, percutaneous intervention for the coronary artery aneurysm, and endovascular embolization for the renal artery aneurysm. Additionally, a systemic infectious workup was initiated to evaluate for an underlying disseminated etiology.\u003c/p\u003e"},{"header":"Discussions","content":"\u003cp\u003eThe subclavian artery, due to its deep anatomical positioning and proximity to the scalene musculature and clavicle, is rarely affected by external trauma or iatrogenic injury [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. However, invasive procedures such as central venous catheter placement have been associated with iatrogenic arterial trauma [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. The development of a subclavian pseudoaneurysm following a cervical lymph node biopsy has not been previously reported, making this a unique and significant addition to the medical literature.\u003c/p\u003e \u003cp\u003eThe clinical presentation of subclavian pseudoaneurysms varies depending on size and location, but a tender, pulsatile mass remains a common feature [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e]. Due to the subclavian artery\u0026rsquo;s proximity to vital neurovascular structures, complications can include chest and shoulder pain, dysphagia, hoarseness, venous congestion, and Horner\u0026rsquo;s syndrome, all of which were observed in this patient [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. In more severe cases, limb ischemia and cerebrovascular events have been reported, making timely diagnosis and intervention imperative [\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eWhile iatrogenic pseudoaneurysms are rare following cervical interventions, their potential for catastrophic complications necessitates a high index of suspicion, particularly in high-risk patients with predisposing vascular pathologies such as HTN, CKD, and CAD. The delayed presentation in this case further emphasizes the need for extended postprocedural surveillance in susceptible individuals.\u003c/p\u003e \u003cp\u003eEndovascular stenting and ultrasound-guided thrombin injection are emerging minimally invasive alternatives to traditional open surgical repair [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. However, surgical excision remains the gold standard in cases with mass effect or impending rupture [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. In this patient, the decision for open surgical reconstruction was dictated by the size, location, and hemodynamic impact of the pseudoaneurysm. Additionally, postoperative surveillance for endoleak remains critical, as secondary intervention may be required [\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e]. Better results can be achieved by emergent management to prevent complications such as rupture or gangrene arising due to thrombosis or embolism [\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eGiven the presence of multiple aneurysms, the possibility of a disseminated infectious etiology such as mycotic aneurysms was strongly considered, reinforcing the need for systemic evaluation and long-term follow-up [\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e].\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThis case underscores the importance of meticulous procedural technique and vigilant postprocedural surveillance in cervical interventions. Clinicians must maintain a high index of suspicion for pseudoaneurysm formation in patients presenting with postprocedural swelling, particularly in complex anatomical regions such as the subclavian artery. Prompt CTA evaluation remains the cornerstone for early diagnosis and management, ultimately preventing life-threatening complications. To the best of our knowledge, this is the first documented case of a biopsy-induced subclavian pseudoaneurysm, emphasizing the need for heightened awareness and refined surgical strategies in similar clinical scenarios.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eStatement on Participant Consent:\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eThe patient gave consent to publish their case\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimers:\u003c/strong\u003e All images and case details are available with the authors of this case report\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eSources of support:\u003c/strong\u003e There was no source of support\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eNumber of tables and figures:\u003c/strong\u003e 5 images (2 CTA, 1 3D reconstruction image, 1 image, 1 chest radiography)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConflict of Interest:\u0026nbsp;\u003c/strong\u003eNo authors have any conflict of interest regarding this case report\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003ePatient Consent:\u0026nbsp;\u003c/strong\u003eThe authors of this article have received and archived written patient consent\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eMašković J, Radonić V, Janković S, Cambj-Sapunar L, Mimica Ž, Bačić A (2001) Traumatic false aneurysm of the subclavian artery treated by insertion of Memotherm stent. Eur J Radiol 38(3):205\u0026ndash;208\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eSubclavian Artery Pseudoaneurysm Following Bedside Temporary Hemodialysis Catheter Insertion A Case Report [Internet]. [cited 2025 Feb 11]. Available from: \u003cspan class=\"ExternalRef\"\u003e\u003cspan class=\"RefSource\"\u003ehttps://www.mdpi.com/1648-9144/59/11/2038\u003c/span\u003e\u003cspan address=\"https://www.mdpi.com/1648-9144/59/11/2038\" targettype=\"URL\" class=\"RefTarget\"\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eFrancis D, Kumar M, Singh M, Okafor TL, Reddy MMRK, Inban P et al (2023) Endovascular management of traumatic pseudoaneurysm of left subclavian artery: A case report. Radiol Case Rep 18(11):4066\u0026ndash;4070\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eJaiswal LS, Prasad JN, Maharjan R, Pandit N (2018) Giant pseudoaneurysm of subclavian artery after blunt chest trauma. J Vasc Surg Cases Innov Tech 4(3):220\u0026ndash;222\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eAlmadwahi N, Halboob E (2022) Open Surgical Repair of Traumatic Subclavian Artery Pseudoaneurysm: A Case Report. Int Med Case Rep J 15:671\u0026ndash;675\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003eJaiswal D (2022) Management of Subclavian Artery Pseudoaneurysm. Case Ser. ;5(1)\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":true,"highlight":"","institution":"Jawaharlal Institute of Post Graduate Medical Education and Research","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"
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