A prospective randomized trial comparing a GnRH analogue, zoladex, and danazol as agents for priming the endometrium prior to endometrial laser ablation

A randomized controlled trial of 160 patients undergoing endometrial laser ablation (ELA) was performed. Patients selected for ELA were randomized to receive either danazol or the GnRH analog Zoladex. Eighty patients were allocated to each group. Each group was also randomized to receive either 1 or 2 months of treatment prior to surgery The major end points for the study were patient compliance and drug-related side-effects, operative time and complications, effectiveness of endometrial thinning as judged by ultrasound, histologic measurements, and clinical response at 6 months assessment. Significant differences in the effectiveness of the two preparations were noted.