[Danazol in the treatment of patients with combined pathology of endometrium and myometrium]

Forty-three patients aged 18 to 52 with combined diseases of the uterus and abnormal uterine bleedings were examined and followed up. The patients were prescribed danazon in a dose of 400 mg/day for 6 months to induce a short-term drug pseudomenopause. Immediate (in the cycle of drug discontinuation) and late (6 months after therapy discontinuation) results were assessed. A stable positive effect was observed in 12 women of premenopausal age over the course of 12-month follow-up; 10 patients were operated on for a recurrence of uterine bleedings and growth of uterine myomas. The mechanism of danazon effect on the female reproductive system and prospects of its use in diseases of the endo- and myometrium are discussed.