Recent advances in 17beta-hydroxysteroid dehydrogenases
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This review examines the identities and physiological roles of 17beta-hydroxysteroid dehydrogenases in steroid and lipid metabolism, highlighting their association with endometriosis and potential as drug targets.
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Abstract
The metabolism of steroids at position 17 is catalysed by a growing number of 17beta-hydroxysteroid dehydrogenases (17beta-HSDs). Several human diseases like breast or prostate cancer, endometriosis,metabolic syndrome and mental diseases were associated with dysfunctions of 17beta-HSDs, which consequently became drug targets. This review will focus on identities of 17beta-HSDs and recent advances in analyses of their physiological roles in steroid and lipid metabolism. It will also address the potential of metabolomics in drug development.
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- europepmc
- last seen: 2026-10-22T06:08:12.857683+00:00
- pubmed
- last seen: 2026-10-08T21:06:31.728877+00:00
- unpaywall
- last seen: 2026-05-14T19:30:52.867331+00:00
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine