The Value of 3D Printed Bolus in Adjuvant Intensity-modulated Radiotherapy After Radical Mastectomy for Breast Cancer--A Prospective Cohort Study

The Value of 3D Printed Bolus in Adjuvant Intensity-modulated Radiotherapy After Radical Mastectomy for Breast Cancer--A Prospective Cohort Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The Value of 3D Printed Bolus in Adjuvant Intensity-modulated Radiotherapy After Radical Mastectomy for Breast Cancer--A Prospective Cohort Study Yaxue Wang, Wendie Hu, Bohan Li, Yujie Du, Xinhui Zhou, Fengyan Li This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5018228/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purpose Breast cancer patients may use a bolus to increase the dose of skin in radiotherapy after radical mastectomy. The 3D printed bolus (3DPB) made by individual customization has better fit and conformance. This study aims to provide some reference value for the treatment by analyzing the dosage advantages of 3DPB in radiotherapy after radical mastectomy of breast cancer. Materials and Methods The study included breast cancer patients who received post-mastectomy radiotherapy with 3DPB between January 1, 2022 and April 30, 2023. Researchers retrospectively collected dosage data related to patients' radiotherapy plans, prospectively observed acute and late radiotherapy side-effects in patients of this cohort. Matched sample T-test was used for data conforming to normal distribution, and non-parametric test was used for data not conforming to normal distribution. P<0.05 was considered statistically significant. Results A total of 35 patients were included in this cohort and median follow-up time was 16 months. In the side-effects of radiotherapy, no level 4 acute side-effects occurred. A total of 82.2% of the patients had no obvious side-effects, and 2.7% had a level 3 acute skin side-effects. Level 3 leukocytes, platelets, and erythrocytes decreased in 5.7%, 2.9%, and 2.9%, respectively. No late radiotherapy side-effects of level 2 or higher occurred. In terms of dosage, radiotherapy plans using 3DPB had better conformance (P<0. 001) and dose homogeneity (P<0. 001). The results showed that the V95% dose was higher for the CTV1, CTV2, P-CTV, P-CTV1, and P-CTV2 that covered the 3DPB (all P< 0. 001). Conclusions Overall, the use of 3DPB in radiotherapy of breast cancer is safe and feasible, with low incidence of acute and late side-effects. At the same time, the use of 3DPB can make the dose distribution higher and more uniform, while obtaining a more conformal target area. breast cancer 3D-printed radiotherapy bolus intensity-modulated Full Text Additional Declarations No competing interests reported. Supplementary Files ToxicitycriteriaRTOG.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-5018228","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":359286204,"identity":"e77bed4b-87cc-4991-a581-0ea750e3a9fc","order_by":0,"name":"Yaxue Wang","email":"","orcid":"","institution":"Sun Yat-sen University Cancer Center","correspondingAuthor":false,"prefix":"","firstName":"Yaxue","middleName":"","lastName":"Wang","suffix":""},{"id":359286205,"identity":"edcbc6c9-bb57-4765-9632-352b0d49d84a","order_by":1,"name":"Wendie Hu","email":"","orcid":"","institution":"Sun Yat-sen University Cancer 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intensity-modulated","lastPublishedDoi":"10.21203/rs.3.rs-5018228/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5018228/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003ePurpose\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eBreast cancer patients may use a bolus to increase the dose of skin in radiotherapy after radical mastectomy. The 3D printed bolus (3DPB) made by individual customization has better fit and conformance. This study aims to provide some reference value for the treatment by analyzing the dosage advantages of 3DPB in radiotherapy after radical mastectomy of breast cancer.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMaterials and Methods\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study included breast cancer patients who received post-mastectomy radiotherapy with 3DPB between January 1, 2022 and April 30, 2023. Researchers retrospectively collected dosage data related to patients' radiotherapy plans, prospectively observed acute and late radiotherapy side-effects in patients of this cohort. Matched sample T-test was used for data conforming to normal distribution, and non-parametric test was used for data not conforming to normal distribution. P\u0026lt;0.05 was considered statistically significant.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA total of 35 patients were included in this cohort and median follow-up time was 16 months. In the side-effects of radiotherapy, no level 4 acute side-effects occurred. A total of 82.2% of the patients had no obvious side-effects, and 2.7% had a level 3 acute skin side-effects. Level 3 leukocytes, platelets, and erythrocytes decreased in 5.7%, 2.9%, and 2.9%, respectively. No late radiotherapy side-effects of level 2 or higher occurred. In terms of dosage, radiotherapy plans using 3DPB had better conformance (P\u0026lt;0. 001) and dose homogeneity (P\u0026lt;0. 001). The results showed that the V95% dose was higher for the CTV1, CTV2, P-CTV, P-CTV1, and P-CTV2 that covered the 3DPB (all P\u0026lt; 0. 001).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eOverall, the use of 3DPB in radiotherapy of breast cancer is safe and feasible, with low incidence of acute and late side-effects. At the same time, the use of 3DPB can make the dose distribution higher and more uniform, while obtaining a more conformal target area.\u003c/p\u003e","manuscriptTitle":"The Value of 3D Printed Bolus in Adjuvant Intensity-modulated Radiotherapy After Radical Mastectomy for Breast Cancer--A Prospective Cohort Study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-10-03 03:49:48","doi":"10.21203/rs.3.rs-5018228/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"803a5732-8485-4942-98c2-1fa836b0b0a9","owner":[],"postedDate":"October 3rd, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-10-31T11:53:33+00:00","versionOfRecord":[],"versionCreatedAt":"2024-10-03 03:49:48","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-5018228","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5018228","identity":"rs-5018228","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}