A green approach for metoclopramide quantification in pharmaceutical products. New HPLC and spectrophotometric methods

A green approach for metoclopramide quantification in pharmaceutical products. New HPLC and spectrophotometric methods | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article A green approach for metoclopramide quantification in pharmaceutical products. New HPLC and spectrophotometric methods İbrahim DEMİR, İbrahim Bulduk, Ibrahim A. DARWISH, Hüseyin ENGİNAR This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3699424/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 11 You are reading this latest preprint version Abstract Green spectrophotometric and HPLC methods have been developed for the quantification of metoclopramide. In the spectrophotometric method, it was determined by direct absorbance measurement at 273 nm wavelength using ultrapure water as solvent. The Extend C18 column was used for the HPLC method. The mobile phase system consisted of a combination of ethanol and formic acid solution (pH 2.0; 30:70 v/v). Isocratic elution was applied and the flow rate was set at 1.0 mL min − 1 . Metoclopramide was detected at 273 nm. The methods performed were economical, rapid, environmentally friendly, and simple, providing metoclopramide analysis within 5 minutes. The methods have been successfully applied in pharmaceutical products without matrix interference. The results of the application of the developed methods to pharmaceutical products were statistically compared and no significant difference was observed between the methods. In addition, the greenness assessment of the developed methods was performed using AGREE software. The developed methods are proposed as excellent environmental and operator-friendly alternatives for the quantification of metoclopramide in pharmaceutical formulations. Earth and environmental sciences/Environmental sciences/Environmental chemistry Earth and environmental sciences/Environmental sciences/Environmental impact Earth and environmental sciences/Environmental sciences Metoclopramide Pharmaceuticals Green HPLC Green spectrophotometry AGREE Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Editorial decision: Revision requested 19 Mar, 2024 Reviews received at journal 12 Mar, 2024 Reviewers agreed at journal 12 Mar, 2024 Reviews received at journal 12 Dec, 2023 Reviewers agreed at journal 06 Dec, 2023 Reviewers agreed at journal 06 Dec, 2023 Reviewers invited by journal 06 Dec, 2023 Editor assigned by journal 06 Dec, 2023 Editor invited by journal 05 Dec, 2023 Submission checks completed at journal 05 Dec, 2023 First submitted to journal 03 Dec, 2023 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3699424","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":256691991,"identity":"2101aee8-5a97-4949-8822-c2211c09c007","order_by":0,"name":"İbrahim DEMİR","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA/klEQVRIiWNgGAWjYBACNgkGBmYGAwbGBiBi/vvHBijG2HiAaC0MvA1pIC0NeLUwgLWAlIE4vA2HwYJ4tfBJ9z78XFCwTbZf7HDbB8kd5+3Wth8G2lJjE43TYTLHjaVnGNw2njk7sXmG4ZnbydvOJAK1HEvLbcDplzQGaR6D24kbbic2MySw3U42OwDUwthwGJ8W5t8gLftBWg6wnUs2O/+QoBY2iC3Sic2MjW0H7MxuELJF5hibNVCL8QygLcwMZ5ITzG4AbUnA4xf52W3Mt3n+3Jbtn53+mJmhws7e7Hz6wwcfamxwasEAiWCVCcQqBwF7UhSPglEwCkbByAAAz+1ismpmpr4AAAAASUVORK5CYII=","orcid":"","institution":"Afyon Kocatepe University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"İbrahim","middleName":"","lastName":"DEMİR","suffix":""},{"id":256691992,"identity":"d9012903-2472-49c6-8ae4-3c60b9049a9e","order_by":1,"name":"İbrahim Bulduk","email":"","orcid":"","institution":"Afyon Kocatepe University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"İbrahim","middleName":"","lastName":"Bulduk","suffix":""},{"id":256691993,"identity":"dda35db9-9cc4-4ed0-8336-6bc1232739ce","order_by":2,"name":"Ibrahim A. 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