p53 in Endometriosis

Khush Mittal, Mittal K
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2002 · vol. 21(1) , pp. 93 · doi:10.1097/00004347-200201000-00019 · PMID:11791586 · W2075851901
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The author suggests reviewing negative controls for false positive staining due to endogenous biotin in endometriotic lesions, noting a similar pattern to focal p53 expression.

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This letter to the editor critiques a previous study by Nakayama et al. regarding focal p53 expression in endometriotic lesions, highlighting a potential methodological flaw involving endogenous biotin. The author notes personal observations of similar staining patterns and suggests that negative controls were not adequately addressed to rule out false positives caused by this biological factor. Consequently, the validity of the original findings regarding p53 expression without genetic alterations is questioned due to these technical concerns. This paper is centrally about endometriosis — specifically addressing diagnostic challenges and immunohistochemical artifacts within endometriotic lesions.

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Abstract

To the Editor: I read with interest the recent article by Nakayama et al. describing focal p53 expression in endometriotic lesions (1). I have occasionally observed endogenous biotin expression in endometriotic lesions (personal observation) in a pattern very similar to that illustrated in Figure 2 of the article (isolated cells with intense nuclear staining). Although the Materials and Methods section did not mention negative controls, I presume these were done. Negative controls should be reviewed to rule out the possibility of false positive staining due to endogenous biotin. Khush Mittal, M.D.
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To the Editor: I read with interest the recent article by Nakayama et al. describing focal p53 expression in endometriotic lesions (). I have occasionally observed endogenous biotin expression in endometriotic lesions (personal observation) in a pattern very similar to that illustrated in Figure 2 of the article (isolated cells with intense nuclear staining). Although the Materials and Methods section did not mention negative controls, I presume these were done. Negative controls should be reviewed to rule out the possibility of false positive staining due to endogenous biotin. Khush Mittal, M.D.REFERENCES - 1. Nakayama K, Toki T, Zhai YL, et al. Demonstration of focal p53 expression without genetic alterations in endometriotic lesions. Int J Gynecol Pathol 2001; 20: 227–31.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Tumor Suppressor Protein p53 Endometriosis Female Humans Tumor Suppressor Protein p53

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