Novel Lipidomes Profile and Clinical Phenotype Identified in Pneumoconiosis Patients

Abstract Pneumoconiosis is a group of occupational lung diseases caused by inhalation of particles of coal, asbestos, silica, or similar substances, leading to fibrosis and loss of lung function. It is the most serious and common occupational disease in the world with an increased incidence but poor prognosis. To further investigate the regulatory mechanisms of lipidomic profiles in pneumoconiosis, we measured plasma lipidomic profiles between pneumoconiosis patients and health. Compared with healthy people, the circulating levels of phosphatidylethanolamine (PE) significantly increased while phosphatidylcholines (PC) and lysophosphatidylcholines (lyso PC) decreased in patients with pneumoconiosis. Clinical trans-omics analyses demonstrated that phenomes in pneumoconiosis was closely correlated with multiple lipids. Our data suggested that trans-omic analysis between clinical phenomes and lipidomes might have the potential to uncover the heterogeneity of lipid metabolism of pneumoconiosis patients and to screen out clinically significant phenome-based lipid panels with potential diagnostic application.