Expression of Leptin and Leptin Receptor in Endometrium of Ectopic and Eutopic of Ovarian Endometriosis

Dongxue Zhang; Huili Zhu; Wei Huang; Qiang Zhang; Chun Guo; Dong Liu; Yan Huang

doi:10.3877/cma.j.issn.1673-5250.2011.04.007

Expression of Leptin and Leptin Receptor in Endometrium of Ectopic and Eutopic of Ovarian Endometriosis

Dongxue Zhang, Huili Zhu, Wei Huang, Qiang Zhang, Chun Guo, Dong Liu, Yan Huang

In: Chung-Hua Fu Ch'an K'o Tsa Chih · 2011 · vol. 7(4) , pp. 313–317 · doi:10.3877/cma.j.issn.1673-5250.2011.04.007 · W3150479264

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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Leptin and its receptor were expressed in ectopic and eutopic endometrium, with lower levels in ectopic endometrium compared to eutopic and control tissues.

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This study examined the expression of leptin and the leptin receptor (Ob-R) in ectopic and eutopic endometrium from 25 patients with surgically confirmed ovarian endometriosis, comparing them with 24 control subjects with uterine myoma, using immunohistochemistry (SP method) on glandular epithelial cells and stromal cells. Leptin and Ob-R were detected in both ectopic and eutopic endometrial tissues and in control normal endometrium, with leptin higher in glands than stroma within group A, while stromal leptin in group A was lower than in group B and controls. Although leptin receptor expression in group A glands was lower than in group B and controls, there were no significant differences in stromal receptor expression, and leptin receptor did not differ by menstrual phase in group A versus controls. The authors conclude that the lower expression of leptin and Ob-R in ectopic lesions suggests limited involvement of the leptin system in ovarian endometriosis development. This paper is centrally about endometriosis — it directly measures leptin and leptin receptor expression in ectopic versus eutopic endometrium in ovarian endometriosis.

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Abstract

Objective To study the expression of leptin and leptin receptor (Ob-R)in ectopic and eutopic endometrium from women with ovarian endometriosis(EMs), and to explore their role in pathogenesis of ovarian endometriosis. Methods Twenty-five subjects with surgically confirmed ovarian endometriosis were chosen for study in the West China Second University Hospital of Sichuan University from July to November 2008. Expression of leptin and leptin receptor in the ectopic endometrium (group A)and eutopic endometrium (group B) of endometriosis was detected by immunohistochemical SP method. Meanwhile, 24 subjects with uterus myoma were chosen as control group. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of West China Second University Hospital, Sichuan University. Informed consent was obtained from all participants. Results Leptin and leptin receptor were localized in intracytoplasm of glandular epithelial cells and stromal cells in the ectopic and eutopic endometrium of endometriosis and in the normal endometrium of control group. The expression of leptin in the glandular epithelial cells of group A was statistically higher than that in the stromal cells (P 0.05), but the expression of leptin in the stroma cells of group A was statistically lower than that in group B and control groups (P 0.05). The expression of leptin receptor in the glandular epithelial cells of group A was statistically lower than that in group B and control groups (P 0.05). In group B, the expression of leptin in the glandular epithelial cells and stromal cells in proliferative phase was higher than that in secretory phase, but there was no statistical significance (P>0.05); meanwhile, the expression of leptin in both glandular epithelial cells and stromal cells of the proliferative phase of control group were statistically higher than those in the secretory phase (P 0.05). Conclusion The lower expression of leptin and leptin receptor in the ectopic endometrium of ovarian endometriosis indicates that the role of leptin and leptin receptor in the pathogenesis of ovarian endometriosis is limited. Key words: endometriosis(EMs); leptin; leptin receptor(Ob-R)

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Objective

To study the expression of leptin and leptin receptor (Ob-R)in ectopic and eutopic endometrium from women with ovarian endometriosis(EMs), and to explore their role in pathogenesis of ovarian endometriosis.

Methods

Twenty-five subjects with surgically confirmed ovarian endometriosis were chosen for study in the West China Second University Hospital of Sichuan University from July to November 2008. Expression of leptin and leptin receptor in the ectopic endometrium (group A)and eutopic endometrium (group B) of endometriosis was detected by immunohistochemical SP method. Meanwhile, 24 subjects with uterus myoma were chosen as control group. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of West China Second University Hospital, Sichuan University. Informed consent was obtained from all participants.

Results

Leptin and leptin receptor were localized in intracytoplasm of glandular epithelial cells and stromal cells in the ectopic and eutopic endometrium of endometriosis and in the normal endometrium of control group. The expression of leptin in the glandular epithelial cells of group A was statistically higher than that in the stromal cells (P0.05), but the expression of leptin in the stroma cells of group A was statistically lower than that in group B and control groups (P0.05). The expression of leptin receptor in the glandular epithelial cells of group A was statistically lower than that in group B and control groups (P0.05). In group B, the expression of leptin in the glandular epithelial cells and stromal cells in proliferative phase was higher than that in secretory phase, but there was no statistical significance (P>0.05); meanwhile, the expression of leptin in both glandular epithelial cells and stromal cells of the proliferative phase of control group were statistically higher than those in the secretory phase (P0.05).

Conclusion

The lower expression of leptin and leptin receptor in the ectopic endometrium of ovarian endometriosis indicates that the role of leptin and leptin receptor in the pathogenesis of ovarian endometriosis is limited. | 1 Cédric C, Christine N. Metz YA, et al. Up-regulation of cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic cells by macrophage migration inhibitory factor: Involvement of novel kinase signaling pathways[J]. Endocrinology, 2009, 19: 1088-2008. | | | 2 Xavier P, Beires J. Endometriosis clinical aspects: Sub and endometrial blood flow in patients with endometriosis[J]. Hum Reprod, 2004, 19: 1168. | | | 3 Zhu HL, Huang W. The role of VEGF in the pathogenesis of endometriosis[J]．Prog Obstet Gynecol，2006，15(9): 678-680. [朱慧莉，黄薇. VEGF在子宫内膜异位症发病机制中的作用[J]. 现代妇产科进展，2006, 15(9): 678-680.] | | | 4 Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R[J]．Cell, 1995, 83(7): 1263-1271. | | | 5 Placido G, Alviggi C, Carravetta C, et al. The peritoneal fluid concentration of leptin is increased in women with peritoneal but not ovarian endometriosis[J]. Hum Reprod, 2001, 16(6): 1251-1254. | | | 6 Matarese G, Alviggi C, Sanna V, et al. Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis[J]. J Clin Endocrinol Metab, 2000, 85(7): 2483-2487. | | | 7 Mahutte NG, Matalliotakis IM, Goumenou AG, et al. Inverse correlation between peritoneal fluid leptin concentrations and the extent of endometriosis[J]. Hum Reprod, 2003, 6(18): 1205-1209. | | | 8 Wu MH, Chuang PC, Chen HM, et al. Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulation[J]. Mol Hum Reprod, 2002, 8(5): 456-464. | | | 9 Lima-Couy I, Cervero A, Bonilla-Musoles F, et al. Endometrial leptin and leptin receptor expression in women with severe/moderate endometriosis[J]. Mol Hum Reprod, 2004, 10(11): 777-782. | | [1] | 朱成美, 赵巧梅, 邓学东. 经阴道超声联合生理盐水灌注直肠子宫陷凹对腹膜型子宫内膜异位症的诊断价值[J/OL]. 中华医学超声杂志（电子版）, 2024, 21(01): 32-36. | | [2] | 乔林. 子宫内膜异位症鉴别诊断病例分享[J/OL]. 中华妇幼临床医学杂志(电子版), 2024, 20(02): 248-. | | [3] | 魏丽坤, 张旭红, 罗营, 薛凤霞, 王颖梅, 宋学茹, 田丽娜, 张艳芳, 王艳霞, 田文艳. 卵巢子宫内膜异位囊肿发生恶变并发盆腔脓肿1例并文献复习[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(06): 696-702. | | [4] | 罗丹, 孔为民, 陈姝宁, 赵小玲, 谢云凯. 子宫内膜异位症患者在位及异位内膜上皮细胞-间充质转化相关生物标志物的变化[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 530-539. | | [5] | 张蕾, 彭超, 周应芳. 直肠阴道隔子宫内膜异位症腹腔镜手术技巧[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 257-261. | | [6] | 胡启明, 鄢潇, 尤志学, 黄骁昊. 经瘢痕处单孔腹腔镜下切除多病灶腹壁子宫内膜异位症[J/OL]. 中华腔镜外科杂志(电子版), 2024, 17(05): 314-317. | | [7] | 芦煜, 李振宇, 吴承东, 周仲伍. 肛周子宫内膜异位症一例报告[J/OL]. 中华结直肠疾病电子杂志, 2024, 13(05): 431-434. | | [8] | 陈娟, 邓静敏. 胸部子宫内膜异位综合征的研究进展[J/OL]. 中华临床医师杂志(电子版), 2024, 18(01): 96-100. | | [9] | 王丁然, 迟洪滨. 自身免疫甲状腺炎对子宫内膜异位症患者胚胎移植结局的影响[J/OL]. 中华临床医师杂志(电子版), 2023, 17(06): 682-688. | | [10] | 方辉, 李菲, 张帆, 魏强, 陈强谱. 外源性瘦素对梗阻性黄疸大鼠肠黏膜增殖的影响[J/OL]. 中华临床医师杂志(电子版), 2023, 17(05): 575-580. | | [11] | 杨思雨, 杨晶晶, 张平, 刘巧, 吴杰, 黄香金, 王怡洁, 付景云. 瘦素通过α1肾上腺素受体介导CaMKKβ-AMPKα信号通路在GT1-7细胞系中的作用[J/OL]. 中华临床医师杂志(电子版), 2023, 17(05): 569-574. | | [12] | 王宁, 吴慢莉, 杨东霞. 代谢组学生物标志物：子宫内膜异位症诊疗的新靶点[J/OL]. 中华临床医师杂志(电子版), 2022, 16(12): 1280-1283. | | [13] | 兰素伟, 王春辉, 常丽凤, 王杏茶, 翟明晶, 李阳. 血清miRNA-10b和miRNA-34a在子宫内膜异位症患者中的表达及与术后复发关系研究[J/OL]. 中华临床医师杂志(电子版), 2022, 16(08): 759-763. | | [14] | 汪泉, 周英妹, 何颖. p27、cyclin-E在子宫内膜异位症中的表达及其临床意义[J/OL]. 中华临床医师杂志(电子版), 2022, 16(06): 546-552. | | [15] | 洪凡, 陈敦金, 傅洋, 梁新月, 吴毅, 王晓怡. 体外受精-胚胎移植妊娠合并前置胎盘临床研究[J/OL]. 中华产科急救电子杂志, 2024, 13(03): 176-182. | | 阅读次数 | ||||| | 全文 | | |||| | 摘要 | | |||| 版权所有中华医学会中华医学电子音像出版社有限责任公司京ICP备14006079号-1 网络出版服务许可证：(署)网出证(京)字第075号 AI 小编 AI小编

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