Concentration TNF-α in peritoneal fluid of endometriotic patients

TEDJA DANUDJA OEPOMO, Tedjo Danudjo Oepomo
In: Asian Journal of Tropical Biotechnology · 2005 · vol. 2(2) , pp. 54–57 · doi:10.13057/biotek/c020204 · W2949328361
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-08-12 ⓘ

This study found significantly higher concentrations of TNF-α in the peritoneal fluid of endometriosis patients compared to control subjects, indicating TNF-α is a risk factor for endometriosis.

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This study examined whether tumor necrosis factor-alpha (TNF-α) is involved in endometriosis by comparing peritoneal-fluid concentrations in 20 women undergoing laparoscopy for endometriosis and 20 women aged 23–40 undergoing laparoscopic interval sterilization at Dr. Muwardi Hospital, with TNF-α measured using ELISA. TNF-α concentrations were significantly higher in the endometriosis group than in the comparison group (P=0.00), and high TNF-α levels were associated with a reported 171-fold greater odds of endometriosis; the authors therefore identified elevated TNF-α as a possible pathogenic factor and risk marker. The abstract does not describe specific study limitations beyond the relatively small, hospital-based groups. This paper is centrally about endometriosis — it evaluates peritoneal-fluid TNF-α concentrations as a potential pathogenic factor.

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Abstract

The aim of this research was to expose the role of tumor necrotic factor alpha (TNF-α) in the pathogenetic endometriosis. This research had been done in dr. Muwardi Hospital Surakarta. Twenty patients undergoing laparoscopic operation because of endometriosis indication (Group I), 20 women (aged 23 to 40) who undergo interval sterilization by means of laparoscopic technique (Group II). During laparoscopic operation, peritoneal fluid is taken to examine TNF-α by ELISA technique. The results indicated that by independent t-test, a significant difference of concentration of TNF-α in the peritoneal fluid is found between endometriosis patients and normal women (who are sterilized) (P=0.00). By chi-square test, the Ratio Odds value 171 shows that the high concentration of TNF-α will increase the possibility of endometriosis 171 times rather than the low TNF-α. It could be concluded the high concentration of TNF-α is the risk factor of endometriosis in comparison with the low TNF-α. It shows that quite possibly TNF-α has a role in the pathogenic endometriosis.
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Concentration TNF-α in peritoneal fluid of endometriotic patients Main Article Content Abstract The aim of this research was to expose the role of tumor necrotic factor alpha (TNF-α) in the pathogenetic endometriosis. This research had been done in dr. Muwardi Hospital Surakarta. Twenty patients undergoing laparoscopic operation because of endometriosis indication (Group I), 20 women (aged 23 to 40) who undergo interval sterilization by means of laparoscopic technique (Group II). During laparoscopic operation, peritoneal fluid is taken to examine TNF-α by ELISA technique. The results indicated that by independent t-test, a significant difference of concentration of TNF-α in the peritoneal fluid is found between endometriosis patients and normal women (who are sterilized) (P=0.00). By chi-square test, the Ratio Odds value 171 shows that the high concentration of TNF-α will increase the possibility of endometriosis 171 times rather than the low TNF-α. It could be concluded the high concentration of TNF-α is the risk factor of endometriosis in comparison with the low TNF-α. It shows that quite possibly TNF-α has a role in the pathogenic endometriosis.

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endometriosis

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