Significance of different expressions of estrogen receptor and progesterone receptor in hysteromyoma and adenomyosis

Objective To explore the characteristic of different expressions of estrogen receptor(ER) and progesterone receptor(PR) in hysteromyoma,adenomyosis and endometrium tissues.Method By taking immunohistochemical staining method(Evision method),we compared 38 hysteromyoma cases with 30 adenomyosis cases,through which we can get the relevant consistencies of ER and PR by testing the respective densities of them in myoma tissues and endometrium tissues of hysteronyoma and adenomyoma tissues and endometrium tissues of adenomyosis.Results In hysteromyoma cases,the expressions of ER and PR in myoma tissues are significantly lower than those in endometrium tissues;while in adenomyosis cases,the expressions of ER and PR in adenomyoma tissues are significantly lower than those in endometrium tissues.In hysteromyoma cases,the expressions of ER and PR are just matching the change rules,which are stronger in proliferative than that in secretory phase.But in adenomyosis cases,except the expression of PR in endometrium tissues,the expressions of both ER and PR lose their periodical cycle.Conclusions The occurrence of hysteromyoma is related to the levels of estrogen and progesterone and the periodical cycle of expressions of their receptors.The low expressions and non-periodical consistencies change patterns of ER and PR in adenomyoma tissues,and the non-periodical consistency change patterns of ER in endometrium tissues may associate with the occurrence and development of endometriosis uterine.