The Influence of Microorganisms on the Onset and Development of Colorectal Cancer in Humans, a Descriptive Cross-Reference Study

Background: The aim of this study is to determine which types of microorganisms influence on the onset and development of colorectal cancer (CRC) in humans. Methods: In patients with CRC, three swabs were taken for microbiological analysis during surgical removal of cancer: first swab from the surface of the healthy intestinal mucosa, the second from the surface of the tumor and the third from the middle of the tumor tissue. Results: In the healthy mucosa of the colon, the most prevalent was Escherichia coli at 70.5%, followed by Enterococcus spp. (47.7%) and Klebsiella/Enterobacter (20.5%). Microbiological analysis of the swabs from the surface of tumor tissue showed that E. coli was the most prevalent at 72.7%, followed by Enterococcus spp. 40.9%, Klebsiella/Enterobacter 25%, and Pseudomonas aeruginosa 20%. In the center of tumor tissue, E. coli was the most prevalent in 77.3% of samples, followed by Enterococcus spp. 47.7%, Klebsiella 27%, and Pseudomonas aeruginosa 18.2%. Conclusion: Certain types of bacteria can influence the emergence and development of cancer, while other types can suppress the development of tumor tissue. Microbiological analysis of human stool samples can be a prevention of the development of CRC.