Predict protein-protein interactions from protein primary sequences: using wavelet transform combined with stacking algorithm

Most biological processes within a cell are carried out by protein-protein interaction (PPI) networks, or so called interactomics. Therefore, identification of PPIs is crucial to elucidating protein functions and further understanding of various cellular biological processes. Currently, a series of high-throughput experimental technologies for detect PPIs have been presented. However, the time-consuming and labor-driven characteristics of these methods forced people to turn to virtual technology for PPIs prediction. Herein, we developed a new predictor which uses stacking algorithm with information extraction by wavelet transform. When applied on the Saccharomyces cerevisiae PPI dataset, the proposed method got a prediction accuracy of 83.35% with sensitivity of 92.95% at the specificity of 65.41%. An independent data set of 2726 Helicobacter pylori PPIs was also used to evaluate this prediction model, and the prediction accuracy is 80.39%, which is better than that of most existing methods.