Effect of progesterone and utrogestan on functional liver condition in patients with dysfunctional uterine bleeding

The effect of progesterone and utrogestan on protein synthetical, fermentative and chromogenic functions of liver in patients with dysfunctional uterine bleedings (DUB) has been studied. 106 women ages 18 to 44 years with hormonal insufficiency of ovarial yellow bodies were examined. The functional condition of the liver was estimated through the content of protein, albumin, globulin, general bilirubin and its connective and free fractions, alanin - and aspartatami-notrasferase, gammaglutamiltranspeptidase, phosphatase alkaline, general and nonprotein sulfhydric groups in blood. The general and effective concentration of albumin was defined in blood serum. It is shown that the concentration of general protein, albumin, general and nonprotein sulfhydric groups decreased by the increased activity of indicated enzymes in patients. It was accompanied by endogenic intoxication. Progesterone treatment decreased the activity of protein synthetical function of liver reducing endocellular fermentative reactions and increasing the level of endogenic intoxication. Therapy by utrogestan resulted in hyperfermentation in patients with endotoxicosis and hypoproteinemia. Therefore patients with DUB suffered from disorders in metabolic function of liver