Study on clinical significance of expressions of VEGF and MVD in patients with adenomyosis

Objective To study the expressions of vascular endothelial growth factor (VEGF) and microvessel density(MVD)in eutopic and ectopic endometria in patients with adenomyosis and their clinical significance in occurrence of menorrhalgia and menorrhea in patients with adenomyosis.Methods Eutopic and ectopic endometrium specimens of 51 patients with adenomyosis after hysterectomy and 40 normal endometrium samples as control group were examined and studied.Expressions of VEGF and MVD in endometrial cells were examined by SP immunohistochemical method.Results ①Expressions of VEGF and MVD in ectopic endometrium tissue were significantly higher than those in eutopic endometria and normal controls (P0.05).②The expression of VEGF was positively correlated with MVD (P0.05).③Menorrhea had positive correlation with the expressions of VEGF and MVD in eutopic endometria of patients with adenomyosis (P0.05).Menorrhalgia was not correlated with the expressions of these factors in eutopic endometria of patients with adenomyosis(P0.05).Conclusion The high expressions of VEGF and MVD in eutopic endometria suggest that angiogenesis is related to the pathogenesis of adenomyosis and menorrhea.