Overcoming the Complexity of Total Laparoscopic Hysterectomy and Bilateral Salpingo-Oophorectomy in a Patient With Uterine Didelphys and Dual Endometrial Pathology: A Surgical Approach in a Complex Anatomical Variant.

A perimenopausal nulliparous woman with a history of two miscarriages and a known diagnosis of uterine didelphys presented with long-standing irregular and heavy menstrual bleeding that had progressively affected her quality of life. Her condition was incidentally diagnosed in early adulthood during evaluation for an abnormal cervical smear, which revealed a double vagina and double cervix; later, she was confirmed to have uterine didelphys. At that time, she underwent vaginal septum excision for dyspareunia and difficulties using tampons. Initial management with pharmacological agents, including mefenamic acid, tranexamic acid, and progestogen-only pills (minipills), provided only limited benefit. Subsequently, she trialled a levonorgestrel-releasing intrauterine system (Mirena®) to control her symptoms. Office hysteroscopy initially showed two narrow cervices and two narrow uterine cavities with otherwise normal-appearing endometrium; biopsies were obtained. Transvaginal ultrasonography demonstrated uterine duplication with variable endometrial thickness over time: an earlier scan recorded right 7.0 mm and left 7.1 mm, while a later scan recorded right 7.0 mm and left 2.3 mm. Further evaluation with hysteroscopy and directed endometrial biopsies demonstrated persistent atypical endometrial hyperplasia in one uterine cavity and endometrial hyperplasia without atypia in the contralateral uterus. Given the malignant potential of atypical endometrial hyperplasia and the failure of conservative management with a Mirena device for nearly one year, definitive surgical treatment was recommended after review and detailed patient counselling. The patient underwent a total laparoscopic hysterectomy with bilateral salpingo-oophorectomy. Preoperatively, renal ultrasonography was undertaken to exclude associated urological anomalies; no abnormalities were identified. Intraoperatively, two separate uterine bodies and two cervices were confirmed. A standard four-port laparoscopic technique was employed. Because of the complex anatomy, a McCartney tube was inserted vaginally to aid fornix identification, maintain pneumoperitoneum following colpotomy, and facilitate secure closure of the vaginal vault (Video  1 ). The video demonstrates the use of a McCartney tube to aid fornix identification, maintain pneumoperitoneum after colpotomy, and facilitate secure laparoscopic vault closure. Each hemi-uterus and adnexa were mobilised with meticulous dissection and bilateral ureteric identification. The infundibulopelvic and round ligaments were coagulated and transected individually. Broad ligaments were opened, and the uterine arteries were skeletonised and secured bilaterally using a LigaSure device. The median raphe between the two cervices was carefully dissected, followed by circumferential colpotomy around both cervices under McCartney tube guidance. Both uteri and adnexa were removed vaginally, and the vaginal vault was closed laparoscopically with a continuous barbed V-Loc suture, achieving good approximation and haemostasis. Estimated blood loss was about 100 mL, and no intraoperative complications occurred. The patient tolerated the procedure well, with an uneventful postoperative recovery, and was discharged on day two after surgery. Histopathological examination of the specimen comprised two uteri with two cervices, and bilateral adnexa reveals that one uterine cavity showed residual atypical endometrial hyperplasia with treatment effect; the contralateral cavity showed benign endometrium without atypia or malignancy. The myometrium contained adenomyosis and a small leiomyoma. Both ovaries revealed occasional benign follicular/functional cysts and were free of neoplasia. Cervices, parametria, and fallopian tubes were unremarkable (Table 1 ). At six weeks postoperatively, the patient was well with no urinary, bowel, or vault-related complications and was started on hormone replacement therapy for surgical menopause. At six months, she remained asymptomatic, with no late complications, and her menopausal symptoms were effectively managed with ongoing hormone therapy in line with standard care. Table 2 summarises the chronological clinical course, diagnostic findings, and key management interventions in this patient. Table 3 summarises the preoperative and postoperative findings for both uteri and adnexa.

Uterine didelphys is a rare Müllerian duct anomaly characterised by complete duplication of the uterus and cervix. It results from the failure of midline fusion of the paramesonephric ducts during embryogenesis [ 1 ]. Müllerian anomalies occur in approximately 4-7% of the general female population, with higher prevalence in selected groups such as infertile women 6-7%, and about 13-16% among those with a history of recurrent pregnancy loss [ 2 ]. They are classified by the American Society for Reproductive Medicine according to the extent of fusion and resorption defects, with uterine didelphys representing a complete fusion anomaly [ 3 ]. While many women with this condition remain asymptomatic, it is sometimes associated with menstrual irregularities, reproductive challenges, or anomalous pelvic anatomy that complicates surgical procedures; duplication of the uterine corpus and cervices can laterally displace the uterine arteries and ureters, increasing intraoperative risk such as vascular or ureteric injuries [ 4 ]. Endometrial hyperplasia with or without atypia can be managed initially with progestin therapy to reverse the pathology and lower malignant potential changes. However, atypical hyperplasia carries a higher risk of progression to endometrial carcinoma. Therefore, definitive surgical intervention is necessary when conservative management fails or patients prefer surgical treatment. The presence of this condition in the context of uterine didelphys is exceptionally rare and necessitates definitive surgical management [ 5 ]. Laparoscopic hysterectomy is widely accepted for treating premalignant endometrial disease; however, its application in the context of duplicated uterine anatomy presents unique technical obstacles such as distorted landmarks and increased risk of ureteral or vascular injury [ 6 ]. Adjuncts such as the McCartney tube, a transvaginal device that outlines the vaginal fornix and maintains pneumoperitoneum after colpotomy, can enhance safety during dissection and vault closure in complex laparoscopic procedures. Recent evidence comparing different methods of laparoscopic vaginal cuff management highlights the value of thoughtful intraoperative planning and appropriate adjunct use [ 7 ]. We report a rare presentation of uterine didelphys with dual-pattern endometrial hyperplasia refractory to hormonal therapy, managed successfully with total laparoscopic hysterectomy and bilateral salpingo-oophorectomy, where meticulous preoperative planning and intraoperative technique, including the strategic use of a McCartney tube, allowed safe completion of the procedure. This report illustrates how such adaptations can overcome anatomical complexity and support effective surgical outcomes.

Uterine didelphys is an uncommon congenital Müllerian anomaly arising from incomplete fusion of the paramesonephric ducts during embryogenesis [ 8 ]. It is estimated to account for around 8% of all uterine malformations [ 9 ]. While many women remain asymptomatic, some may present with abnormal uterine bleeding, pelvic pain, subfertility, or obstetric complications [ 10 ]. Given the premalignant potential of atypical hyperplasia, definitive surgical intervention is warranted when conservative management fails. Hysterectomy in duplicated uterine anatomy carries distinct risks. Displacement of the uterine arteries and ureters, fused or attenuated peritoneal reflections, and altered tissue planes can increase the likelihood of ureteric or vascular injury [ 6 ]. Different approaches to hysterectomies have been described, but laparoscopic hysterectomies are increasingly favoured due to magnified visualisation, lower morbidity, and faster recovery [ 11 ]. Nonetheless, such procedures require preoperative planning, meticulous intraoperative dissection, and thoughtful intraoperative adaptation. In our case, total laparoscopic hysterectomy with bilateral salpingo-oophorectomy was safely performed despite several anatomic challenges. There was a distortion of the midline pelvic anatomy with the presence of the median raphe. In addition, the broad, irregular configuration of the vaginal vault adds further difficulty to colpotomy and vault closure. In some cases, the uterine arteries and veins may follow atypical courses, and the ureters are displaced, increasing the risk of injury during dissection. The intraoperative use of a McCartney tube proved particularly advantageous, facilitating fornix identification, maintaining pneumoperitoneum after colpotomy, and supporting secure vault closure. While this device has been described in routine laparoscopic hysterectomy [ 12 ], its application in congenital anomalies such as uterine didelphys has rarely been highlighted, underscoring its potential as a valuable adjunct in complex anatomy. The intra- and postoperative course was favourable, and the patient remained well at six-week and six-month follow-up. Histopathology result demonstrated residual atypical endometrial hyperplasia with treatment effect confined to one uterus and benign endometrium in the contralateral uterus, with no invasive malignancy. This case underscores several key learning points. Comprehensive preoperative imaging, including renal tract assessment, is essential, as genitourinary anomalies frequently coexist with Müllerian malformations [ 13 ]. Intraoperative identification of the ureters and careful staging of vascular control are critical to minimising complications. Finally, adjuncts such as the McCartney tube can enhance surgical safety and efficiency in challenging operative scenarios. The limitation of this report is that it is a single case report and it is less generalisable. However, it adds to the scarce body of literature reporting laparoscopic hysterectomy in patients with uterine didelphys and premalignant endometrial pathology and provides a useful intraoperative technique in the management of such cases.

This case demonstrates that total laparoscopic hysterectomy with bilateral salpingo-oophorectomy can be performed safely and effectively in a patient with uterine didelphys and coexisting premalignant endometrial pathology when meticulous preoperative planning and precise surgical execution are applied. The strategic use of a McCartney tube proved invaluable in navigating duplicated pelvic anatomy, facilitating accurate dissection, maintaining pneumoperitoneum, and ensuring secure vault closure. The findings are not generalisable as a single case. Further case accrual and multicentre experience are needed to confirm reproducibility, refine technical steps, and define when adjuncts such as the McCartney tube add measurable benefit in minimally invasive management of complex Müllerian anomalies.