Ketamine Reimagined: Distinguishing Psychedelic and Psycholytic Modalities for Next-Generation Therapies.

Ketamine Reimagined: Distinguishing Psychedelic and Psycholytic Modalities for Next-Generation Therapies. | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 10 December 2025 V1 Latest version Share on Ketamine Reimagined: Distinguishing Psychedelic and Psycholytic Modalities for Next-Generation Therapies. Author : Sophie Holland 0009-0006-5525-9548 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.176538434.48451693/v1 265 views 181 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract This paper explores ketamine as a psychedelic alongside the differential impacts of psychedelic versus psycholytic effects of ketamine in a therapeutic setting. The paper examines existing research to elucidate the broad therapeutic potential of ketamine and the mechanisms underlying each modality. The primary objective is to present the differences between psychedelic and psycholytic applications of ketamine, which is essentially a dose-response effect, focusing on their efficacy in treating mental health disorders such as depression, anxiety, addictions and PTSD. The biochemical interactions and subjective experiences associated with each effect type, contributing to a more developed understanding of ketamine’s therapeutic spectrum is also investigated. This paper seeks to inform clinical practices and future research directions by highlighting the distinct and overlapping benefits of these two paradigms of ketamine when used in therapy. Further research such as the innovative development of the use of ketamine as an enhancement for creativity, teamwork and collaboration alongside other innovative applications have been suggested. Supplementary Material File (ketamine reimagined_ distinguishing psychedelic and psycholytic modalities for next-generation therapies-3.docx) Download 28.66 KB Information & Authors Information Version history V1 Version 1 10 December 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Sophie Holland 0009-0006-5525-9548 [email protected] Sophie Holland View all articles by this author Metrics & Citations Metrics Article Usage 265 views 181 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Sophie Holland. Ketamine Reimagined: Distinguishing Psychedelic and Psycholytic Modalities for Next-Generation Therapies.. Authorea . 10 December 2025. DOI: https://doi.org/10.22541/au.176538434.48451693/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. 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