Effect of alpha-lipoic acid on atrial fibrillation and biomarkers of myocardial injury in patients undergoing coronary artery bypass surgery: Study protocol of a randomized, double-blind, placebo-controlled clinical trial

Effect of alpha-lipoic acid on atrial fibrillation and biomarkers of myocardial injury in patients undergoing coronary artery bypass surgery: Study protocol of a randomized, double-blind, placebo-controlled clinical trial | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Effect of alpha-lipoic acid on atrial fibrillation and biomarkers of myocardial injury in patients undergoing coronary artery bypass surgery: Study protocol of a randomized, double-blind, placebo-controlled clinical trial Rahil Salari-Baghoonabad, Soheil Mansourian, Elham Alipoor, Alireza Jahan-mihan, and 5 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8013165/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 4 You are reading this latest preprint version Abstract Background : Coronary artery bypass grafting (CABG) is associated with several postoperative complications, notably atrial fibrillation (AF), which may arise due to myocardial reperfusion following ischemia and the resulting inflammatory response. Alpha-lipoic acid (ALA) is a potent antioxidant compound known for its ability to reduce oxidative stress and regenerate endogenous antioxidant defenses. The aim of this study is to investigate the effects of ALA supplementation on the incidence of AF and biomarkers of myocardial injury in patients undergoing CABG. Methods : In this randomized, placebo-controlled, parallel-design clinical trial, 50 eligible patients scheduled for CABG, will be randomly assigned into two groups to receive either 1200 mg/day ALA (ALA group, n=25) or placebo (control group, n=25), starting 10 days prior to surgery and continuing for five days after CABG. The occurrence of AF will be monitored using Holter monitoring during the first 72 hours after surgery and electrocardiography (EKG) performed three times daily on postoperative days four and five. Changes in complete blood count (CBC), troponin I, creatine kinase, muscle brain subunits (CK-MB), albumin, total protein, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) concentrations will be assessed at baseline, 24hr and five days after surgery. The length of hospital and intensive care unit (ICU) stay will be recorded. Echocardiography will be performed at baseline and on postoperative day five. Dietary intake will be assessed throughout the study period. Discussion : This trial is expected to provide valuable preliminary data on the effects of ALA supplementation in reducing post-CABG AF and myocardial injury. The findings may lay the groundwork for future research into the adjunctive use of ALA, alone or in combination with other antioxidants, to mitigate complications following CABG. Trial registration : The research protocol has been approved by the Bioethics Committee of Tehran University of Medical Sciences (No. IR.TUMS.THC.REC.1403.052). The trial protocol has also been registered with the Iranian Registry of Clinical Trials (IRCT20131125015536N16). Alpha-lipoic acid Atrial fibrillation Coronary artery bypass grafting Creatine kinase-MB Troponin I Full Text Cite Share Download PDF Status: Under Review Version 1 posted Reviewers agreed at journal 25 Nov, 2025 Reviewers invited by journal 20 Nov, 2025 Editor assigned by journal 17 Nov, 2025 First submitted to journal 15 Nov, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8013165","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":548184956,"identity":"dc176b4d-3ac9-43d1-82eb-5ee0e4e3503e","order_by":0,"name":"Rahil 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acid, Atrial fibrillation, Coronary artery bypass grafting, Creatine kinase-MB, Troponin I","lastPublishedDoi":"10.21203/rs.3.rs-8013165/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8013165/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e: Coronary artery bypass grafting (CABG) is associated with several postoperative complications, notably atrial fibrillation (AF), which may arise due to myocardial reperfusion following ischemia and the resulting inflammatory response. Alpha-lipoic acid (ALA) is a potent antioxidant compound known for its ability to reduce oxidative stress and regenerate endogenous antioxidant defenses. The aim of this study is to investigate the effects of ALA supplementation on the incidence of AF and biomarkers of myocardial injury in patients undergoing CABG.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: In this randomized, placebo-controlled, parallel-design clinical trial, 50 eligible patients scheduled for CABG, will be randomly assigned into two groups to receive either 1200 mg/day ALA (ALA group, n=25) or placebo (control group, n=25), starting 10 days prior to surgery and continuing for five days after CABG. The occurrence of AF will be monitored using Holter monitoring during the first 72 hours after surgery and electrocardiography (EKG) performed three times daily on postoperative days four and five. 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The findings may lay the groundwork for future research into the adjunctive use of ALA, alone or in combination with other antioxidants, to mitigate complications following CABG.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTrial registration\u003c/strong\u003e: The research protocol has been approved by the Bioethics Committee of Tehran University of Medical Sciences (No. IR.TUMS.THC.REC.1403.052). The trial protocol has also been registered with the Iranian Registry of Clinical Trials (IRCT20131125015536N16).\u003c/p\u003e","manuscriptTitle":"Effect of alpha-lipoic acid on atrial fibrillation and biomarkers of myocardial injury in patients undergoing coronary artery bypass surgery: Study protocol of a randomized, double-blind, placebo-controlled clinical trial","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-11-27 13:05:38","doi":"10.21203/rs.3.rs-8013165/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"reviewerAgreed","content":"","date":"2025-11-25T18:07:29+00:00","index":0,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2025-11-20T13:58:14+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-11-17T06:24:35+00:00","index":"","fulltext":""},{"type":"submitted","content":"Trials","date":"2025-11-15T09:22:53+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"trials","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"trls","sideBox":"Learn more about [Trials](http://trialsjournal.biomedcentral.com/)","snPcode":"13063","submissionUrl":"https://www.editorialmanager.com/trls","title":"Trials","twitterHandle":"MedicalEvidence","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"4635d023-f9d1-4145-851d-9701b9525cd2","owner":[],"postedDate":"November 27th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2025-11-27T13:05:38+00:00","versionOfRecord":[],"versionCreatedAt":"2025-11-27 13:05:38","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8013165","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8013165","identity":"rs-8013165","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}