Clinical characteristics of women with reproductive cycle–associated bipolar disorder symptoms
article
OA: closed
CC0
⤵ 1 in-corpus citation
AI-generated summary
Women with bipolar disorder reporting reproductive cycle-associated mood symptoms exhibited earlier onset, more rapid cycling, greater anxiety comorbidity, and mixed moods than those without such associations.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
OBJECTIVE: Although there is clear evidence that reproductive cycle events are associated with mood episodes for women with bipolar disorder, few studies have examined for relationships between these and specific clinical characteristics of the disorder. This study aimed to explore the relationship between mood symptoms associated with reproductive cycle events and features of the disorder indicative of a more severe lifetime course. METHOD: Totally, 158 women of at least 18 years of age participated in the study. Subjects were recruited through a specialist clinic at the Black Dog Institute, Sydney, Australia. RESULTS: In total, 77% of women reported increases in mood symptoms during perimenstrual, postnatal or menopausal periods. These women had an earlier age of onset for depressive and hypo/manic episodes and a greater likelihood of comorbid anxiety disorders, rapid cycling and mixed mood compared to those who did not report such reproductive cycle-associated mood changes. Women who experienced postnatal episodes were also more likely to experience worse mood symptoms perimenstrually and menopausally. CONCLUSION: First, reproductive cycle event-related worsening of mood was associated with a more severe lifetime course of bipolar disorder, and, second, it appears that some women have a greater propensity to mood worsening at each of these reproductive cycle events. If replicated, these findings provide important information for clinicians treating women with reproductive cycle event mood changes and highlight the need for improved therapeutics for such presentations.
My notes (saved in your browser only)
Citation neighborhood (sparse)
Too few in-corpus citations on either side for a chart; here are the lists.
Cites (3)
- The Impact of Reproductive Events on the Course of Bipolar Disorder in Women 2002
- Sex hormones and biomarkers of neuroprotection and neurodegeneration: implications for female reproductive events in bipolar disorder 2013
- Symptom severity of bipolar disorder during the menopausal transition 2015
Cited by (1)
References (20)
- Sex hormones and biomarkers of neuroprotection and neurodegeneration: implications for female reproductive events in bipolar disorder via openalex
- Symptom severity of bipolar disorder during the menopausal transition via openalex
- The Impact of Reproductive Events on the Course of Bipolar Disorder in Women via openalex
- doi:10.1176/appi.ajp.2010.09121816 via openalex
- doi:10.1016/s0006-3223(99)00023-2 via openalex
- doi:10.1002/da.21932 via openalex
- doi:10.1016/j.rbp.2012.04.010 via openalex
- doi:10.1111/bdi.12138 via openalex
- doi:10.1016/s0193-953x(03)00036-4 via openalex
- doi:10.1111/bdi.12329 via openalex
- doi:10.1111/j.1399-5618.2009.00685.x via openalex
- doi:10.1176/appi.ajp.2015.15010124 via openalex
- doi:10.1016/j.jad.2006.08.013 via openalex
- doi:10.5505/kpd via openalex
- doi:10.1080/j.1440-1614.2005.01650.x via openalex
- doi:10.1080/00048670802607220 via openalex
- W186170266 via openalex
- doi:10.1176/ajp.2006.163.7.1173 via openalex
- W1811220737 via openalex
- doi:10.1016/s0165-0327(98)00003-2 via openalex
Cited by (1)
Source provenance
- openalex
- last seen: 2026-05-10T11:21:44.960448+00:00
License: CC0
· commercial use OK